Navigation Links
Experimental stroke drug also shows promise for people with Lou Gehrig's disease
Date:3/3/2014

Keck School of Medicine of USC neuroscientists have unlocked a piece of the puzzle in the fight against Lou Gehrig's disease, a debilitating neurological disorder that robs people of their motor skills. Their findings appear in the March 3, 2014, online edition of the Proceedings of the National Academy of Sciences of the United States of America, the official scientific journal of the U.S. National Academy of Sciences.

"We know that both people and transgenic rodents afflicted with this disease develop spontaneous breakdown of the blood-spinal cord barrier, but how these microscopic lesions affect the development of the disease has been unclear," said Berislav V. Zlokovic, M.D., Ph.D., the study's principal investigator and director of the Zilkha Neurogenetic Institute at USC. "In this study, we show that early motor neuron dysfunction related to the disease in mice is proportional to the degree of damage to the blood-spinal cord barrier and that restoring the integrity of the barrier delays motor neuron degeneration. We are hopeful that we can apply these findings to the corresponding disease mechanism in people. "

In this study, Zlokovic and colleagues found that an experimental drug now being studied in human stroke patients appears to protect the blood-spinal cord barrier's integrity in mice and delay motor neuron impairment and degeneration. The drug, an activated protein C analog called 3K3A-APC, was developed by Zlokovic's start-up biotechnology company, ZZ Biotech.

Lou Gehrig's disease, also called amyotrophic lateral sclerosis, or ALS, attacks motor neurons, which are cells that control the muscles. The progressive degeneration of the motor neurons in ALS eventually leads to paralysis and difficulty breathing, eating and swallowing.

According to The ALS Association, approximately 15 people in the United States are diagnosed with ALS every day. It is estimated that as many as 30,000 Americans live with the disease. Most people who develop ALS are between the ages of 40 and 70, with an average age of 55 upon diagnosis. Life expectancy of an ALS patient averages about two to five years from the onset of symptoms.

ALS's causes are not completely understood, and no cure has yet been found. Only one Food and Drug Administration-approved drug called riluzole has been shown to prolong life by two to three months. There are, however, devices and therapies that can manage the symptoms of the disease to help people maintain as much independence as possible and prolong survival.


'/>"/>
Contact: Alison Trinidad
alison.trinidad@usc.edu
323-442-3941
University of Southern California - Health Sciences
Source:Eurekalert  

Related biology news :

1. The importance of (experimental) design
2. Experimental drug reduces brain damage, eliminates brain hemorrhaging in rodents afflicted by stroke
3. AMP joins the Federation of American Societies for Experimental Biology
4. New findings on tree nuts and health presented at the Experimental Biology Meeting in Boston, Mass.
5. Bridges experimental and bioinformatics perspectives to delineate protein-DNA interactions
6. Experimental gene therapy treatment for Duchenne muscular dystrophy offers hope for youngster
7. Experimental drug combination selectively destroys lymphoma cells
8. Nicole George wins 2012 Journal of Experimental Biology Outstanding Paper Prize
9. Hyperhomocysteinemia patients with dyslipidemia are more likely to have stroke
10. A magnetic nanoparticles-based method for DNA extraction from the saliva after stroke
11. Why do stroke patients show poor limb motor function recovery?
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Experimental stroke drug also shows promise for people with Lou Gehrig's disease
(Date:4/26/2016)... LONDON , April 26, 2016 ... a product subsidiary of Infosys (NYSE: ... to integrate the Onegini mobile security platform with ... http://photos.prnewswire.com/prnh/20151104/283829LOGO ) The integration will ... to access and transact across channels. Using this ...
(Date:4/15/2016)...  A new partnership announced today will help ... in a fraction of the time it takes ... life insurance policies to consumers without requiring inconvenient ... Diagnostics, rapid testing (A1C, Cotinine and HIV) and ... weight, pulse, BMI, and activity data) available at ...
(Date:4/13/2016)... 2016  IMPOWER physicians supporting Medicaid patients in ... clinical standard in telehealth thanks to a new partnership ... platform, IMPOWER patients can routinely track key health measurements, ... index, and, when they opt in, share them with ... a local retail location at no cost. By leveraging ...
Breaking Biology News(10 mins):
(Date:4/27/2016)... , April 27, 2016 ... report with specific focus on US, EU, ... , to the healthcare business intelligence collection ... Complete report on the Flow Cytometry ... and supported with 282 tables and figures is ...
(Date:4/26/2016)... ... April 26, 2016 , ... The European Patent ... selected as one of three finalists for the European Inventor Award 2016 in the ... prize will be announced at a ceremony in Lisbon on June 9th. , The ...
(Date:4/26/2016)... ... ... This unique "Fertility Happy Hour" event will be held at The Saguaro Hotel ... on female fertility and the reproductive technologies that are empowering a new generation of ... The Arizona Center, will give a short presentation and answer questions about age ...
(Date:4/26/2016)... , VIENNA and ... The prize recognizes the ... resulting revolutionary innovations that will benefit patients and ... http://photos.prnewswire.com/prnh/20160210/331945LOGO ) , Norma ... proprietary trend setting products in the field of ...
Breaking Biology Technology: