Navigation Links
Experimental chemotherapy regimen shows promise in treating advanced lung cancer

PHILADELPHIA A combination of chemotherapy agents that have been tested in other tumor types appears to be a promising alternative to standard treatment for advanced non-small cell lung cancer, according to a report in the August 15 issue of Clinical Cancer Research, a journal of the American Association for Cancer Research.

In a phase II multicenter study of 56 patients with an advanced form of this common lung cancer, endpoints including response rate, progression-free survival, and overall survival from use of S-1 and irinotecan were similar to, or better than, those reported from standard treatment with platinum-based chemotherapy regimens.

Because the study had only a single arm meaning all patients received the experimental therapy the researchers cannot say if this regimen offers more benefit than standard treatment. But they did report that side effects resulting from the experimental therapy appeared to be much less severe than those typically seen with standard treatment.

"There continues to be reluctance on the part of both patients and treating physicians to accept the toxicity of platinum-based therapy, given the associated small gain in survival, so active therapies with improved toxicity profiles are clearly needed," said the study's lead investigator, Isamu Okamoto, M.D., Ph.D., associate professor in the Department of Medical Oncology at the Kinki University School of Medicine in Osaka, Japan.

Okamoto says that a direct comparison between this experimental regimen and platinum-based "doublet" chemotherapy should be conducted to confirm what appears to be a survival benefit among patients who used S-1 and irinotecan.

S-1 (also known as TS-1) is approved for use in Japan and Korea, where it has shown substantial benefit in treating gastric cancer, but is still in clinical trials in other countries, including the U.S. and Europe.

The multifaceted agent, which is available in capsule form, has three different mechanisms of action. One part breaks down into active fluorouracil (5-FU) once it is in the body. 5-FU is a chemotherapy drug often used to treat colorectal and other cancers.

Another part of S-1 keeps 5-FU production at a steady level and a third part is designed to counteract 5-FU's toxic effects, such as nausea and vomiting.

Irinotecan, an intravenous drug originally developed and tested in Japan and approved for use in the U.S. in 1994, is most often used to treat colon cancer. It is currently being used in Japan to treat lung cancer, but is not commonly used in this way in other countries, says Okamoto.

The combination of these two agents appears to offer a synergistic effect, he says. When S-1 was tested as first-line chemotherapy for advanced lung cancer, the response rate was 22 percent with a median survival time of 10.2 months. In this study, patients who had not received any treatment for their advanced lung cancer were enrolled at 14 centers in Japan and received a median of five cycles of treatment. The response rate for the combination therapy was 28 percent, median progression-free survival was 4.9 months and median overall survival was 15 months.

Okamoto says these findings compare favorably with previous studies of platinum-based doublets, which demonstrated response rates of 17 to 33 percent, a median time to progression or progression-free survival of three to five months, and a median overall survival time of seven to 14 months. "This is a promising alternative, but needs further testing in randomized trials," he said.


Contact: Jeremy Moore
American Association for Cancer Research

Related biology news :

1. Experimental Biology 2008 meets in San Diego April 5-9
2. Translational research patented first experimental treatment against idiopathic pulmonary fibrosis
3. Experimental Biology and Medicine announces expansion into Asia, opens new office
4. UC health news: molecular pathway may predict chemotherapy effectiveness
5. A search for protection against chemotherapy cardiotoxicity
6. New chemotherapy combo produces side effects, but no extra efficacy, in early breast cancer patients
7. Mitochondrial cholesterol makes response to chemotherapy difficult in hepatic cancer
8. Research shows skeleton to be endocrine organ
9. Clones on task serve greater good, evolutionary study shows
10. Study shows link between alcohol consumption and hiv disease progression
11. Novel 3-D cell culture model shows selective tumor uptake of nanoparticles
Post Your Comments:
(Date:4/26/2016)... DUBLIN , April 27, 2016 ... of the  "Global Multi-modal Biometrics Market 2016-2020"  report ... ) , The analysts forecast ... a CAGR of 15.49% during the period 2016-2020.  ... a number of sectors such as the healthcare, ...
(Date:4/15/2016)... , April 15, 2016  A new ... make more accurate underwriting decisions in a fraction ... timely, competitively priced and high-value life insurance policies ... screenings. With Force Diagnostics, rapid testing ... lifestyle data readings (blood pressure, weight, pulse, BMI, ...
(Date:4/14/2016)... 2016 BioCatch ™, the ... announced the appointment of Eyal Goldwerger as ... Goldwerger,s leadership appointment comes at a time of ... deployment of its platform at several of the world,s ... discerns unique cognitive and physiological factors, is a winner ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... June 27, 2016  Global demand for enzymes ... through 2020 to $7.2 billion.  This market includes ... cleaning products, biofuel production, animal feed, and other ... and biocatalysts). Food and beverages will remain the ... increasing consumption of products containing enzymes in developing ...
(Date:6/27/2016)... , June 27, 2016  Sequenom, Inc. (NASDAQ: ... enabling healthier lives through the development of innovative products ... the United States denied its ... the claims of Sequenom,s U.S. Patent No. 6,258,540 (",540 ... criteria established by the Supreme Court,s Mayo Collaborative Services ...
(Date:6/27/2016)... (PRWEB) , ... June 27, 2016 , ... Parallel ... clinical trials, announced today the Clinical Reach Virtual Patient Encounter CONSULT module ... circle with the physician and clinical trial team. , Using the CONSULT module, patients ...
(Date:6/27/2016)... (PRWEB) , ... June 27, 2016 , ... ... operations for Amgen, will join the faculty of the University of North ... adjunct professor of strategy and entrepreneurship at UNC Kenan-Flagler, with a focus on ...
Breaking Biology Technology: