Navigation Links
Experimental chemotherapy regimen shows promise in treating advanced lung cancer
Date:8/11/2008

PHILADELPHIA A combination of chemotherapy agents that have been tested in other tumor types appears to be a promising alternative to standard treatment for advanced non-small cell lung cancer, according to a report in the August 15 issue of Clinical Cancer Research, a journal of the American Association for Cancer Research.

In a phase II multicenter study of 56 patients with an advanced form of this common lung cancer, endpoints including response rate, progression-free survival, and overall survival from use of S-1 and irinotecan were similar to, or better than, those reported from standard treatment with platinum-based chemotherapy regimens.

Because the study had only a single arm meaning all patients received the experimental therapy the researchers cannot say if this regimen offers more benefit than standard treatment. But they did report that side effects resulting from the experimental therapy appeared to be much less severe than those typically seen with standard treatment.

"There continues to be reluctance on the part of both patients and treating physicians to accept the toxicity of platinum-based therapy, given the associated small gain in survival, so active therapies with improved toxicity profiles are clearly needed," said the study's lead investigator, Isamu Okamoto, M.D., Ph.D., associate professor in the Department of Medical Oncology at the Kinki University School of Medicine in Osaka, Japan.

Okamoto says that a direct comparison between this experimental regimen and platinum-based "doublet" chemotherapy should be conducted to confirm what appears to be a survival benefit among patients who used S-1 and irinotecan.

S-1 (also known as TS-1) is approved for use in Japan and Korea, where it has shown substantial benefit in treating gastric cancer, but is still in clinical trials in other countries, including the U.S. and Europe.

The multifaceted agent, which is available in capsule
'/>"/>

Contact: Jeremy Moore
Jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. Experimental Biology 2008 meets in San Diego April 5-9
2. Translational research patented first experimental treatment against idiopathic pulmonary fibrosis
3. Experimental Biology and Medicine announces expansion into Asia, opens new office
4. UC health news: molecular pathway may predict chemotherapy effectiveness
5. A search for protection against chemotherapy cardiotoxicity
6. New chemotherapy combo produces side effects, but no extra efficacy, in early breast cancer patients
7. Mitochondrial cholesterol makes response to chemotherapy difficult in hepatic cancer
8. Research shows skeleton to be endocrine organ
9. Clones on task serve greater good, evolutionary study shows
10. Study shows link between alcohol consumption and hiv disease progression
11. Novel 3-D cell culture model shows selective tumor uptake of nanoparticles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... (ANU) team has successfully replicated one of the crucial ... powered by sunlight which could manufacture hydrogen as a ... It is an exciting prospect to use them to ... Dr Kastoori Hingorani, from the ARC Centre of Excellence ... Biology. , Hydrogen offers potential as a zero-carbon replacement ...
(Date:8/20/2014)... N.Y. In a study of 158 pregnant teenagers ... the craving and intentional consumption of ice, cornstarch, vacuum ... reports a new Cornell study. , Moreover, such teens ... who did not eat nonfood substances. , Pregnant teens, ... hemoglobin, which can lead to iron deficiency and anemia. ...
(Date:8/20/2014)... Tbingen, Arizona State University, the Wellcome Trust Sanger Institute ... TPH) isolated Mycobacterium pinnipedii from skeletons found ... The pathogen is a relative of the TB bacterium ... humans today. These researchers assume that seals carried the ... to sea lions was unexpected" comments Sebastien Gagneux, from ...
Breaking Biology News(10 mins):Water and sunlight the formula for sustainable fuel 2Pica in pregnant teens linked to low iron 2
... when it comes to starting a business. Thats the case ... invented a trading card game, Elementeo, that aims to teach ... the 235th National Meeting of the American Chemical Society in ... other 14-year olds play on their Xbox, this precocious CEO ...
... 8, 2008 More good news for pistachio fans! According ... Conference in San Diego, snacking on pistachios has proved once ... by significantly reducing inflammation in the body, a prominent cardiovascular ... one cause of death in the U.S., with millions more ...
... two Queens scientists has resulted in an exciting new method ... weapons and pesticides. Recently completed testing by an independent ... greater than 99 per cent effective when used on the ... in solution, full destruction of all three agents was achieved ...
Cached Biology News:14-year-old CEO makes chemistry a game with 'Elementeo' 2Nutrition research unveiled this week shows pistachios are smart for the heart 2Nutrition research unveiled this week shows pistachios are smart for the heart 3Nutrition research unveiled this week shows pistachios are smart for the heart 4Queen's develops safe 'green' decontamination method 2
(Date:8/21/2014)... The College of New Rochelle announced today ... Mid-Hudson Region to be designated as a START-UP NY ... qualified “high-technology” businesses that align with the College’s academic ... been selected for the START-UP NY program and extremely ... economic development in New York by growing business and ...
(Date:8/21/2014)... Aug. 21, 2014  Four-dimensional (4-D) printing develops ... on external stimuli such as changes in temperature. ... disruptive effect in multiple industries.  In the near ... by printing objects ranging from human organs to ... Logo - http://photos.prnewswire.com/prnh/20140820/138289 ...
(Date:8/21/2014)... On Wednesday of last week RENU 28, the world's first ... available for purchase in Australia and New Zealand, and the ... works is, if you think about the definition of aging, ... renewal within your body. If you think about the definition ... renewal. What RENU 28 does is it works with these ...
(Date:8/20/2014)... , Aug. 20, 2014 Neurotrope, ... host a conference call to provide an update ... p.m. Eastern daylight timeDial-in numbers:(888) 505-4369 (U.S. and ... Live web cast: www.neurotropebioscience.com , under "Investor Relations"The ... after completion through September 2, 2014 at (888) ...
Breaking Biology Technology:The College of New Rochelle Becomes First Private College in Mid-Hudson Region to Earn START-UP NY Designation 2The College of New Rochelle Becomes First Private College in Mid-Hudson Region to Earn START-UP NY Designation 3Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 2Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 3Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 4RENU 28 Skin Care Now Available in Australia and New Zealand 2Neurotrope To Host Conference Call 2
... Batchelor, Lynn Jordan, and Ed Alderman , ... 01748 , Karen Heins and Olaf ... 100 Cummings Center, Suite 107J, Beverly, MA 01915 , ... The goal for plasmid purification is isolation of nucleic acid from cellular material. ...
... Larry Simonson and Lynn Jordan , ... Laboratory, Hopkinton, Massachusetts, USA , ... work in 96 well microplates was commonly carried out using manual ... grown, automated liquid handling has become a necessity for most laboratories. ...
... and Lynn Jordan , Caliper ... Introduction , ... Sciclone Advanced Liquid Handler (ALH). This device is designed to permit individually ... 384 well microplates for purposes of liquid transfer (tertiary dispensing). It can ...
Cached Biology Technology:High Throughput Plasmid DNA Preparation Using A Magnetic Bead Kit On An Automated Workstation 2High Throughput Plasmid DNA Preparation Using A Magnetic Bead Kit On An Automated Workstation 3384 Well Pipetting Precision and Accuracy Testing Using the Sciclone Advanced Liquid Handler 2384 Well Pipetting Precision and Accuracy Testing Using the Sciclone Advanced Liquid Handler 3384 Well Pipetting Precision and Accuracy Testing Using the Sciclone Advanced Liquid Handler 4Precision Testing for the Sciclone Advanced Liquid Handler Z8 Option 2Precision Testing for the Sciclone Advanced Liquid Handler Z8 Option 3Precision Testing for the Sciclone Advanced Liquid Handler Z8 Option 4Precision Testing for the Sciclone Advanced Liquid Handler Z8 Option 5
Superior homology search software - in all the flavours of blast, with increased sensitivity and speed. Free windows version for academic use....
Full service including gene cloning, protien expression and purification of 1 liter culture....
Protein 3D structure prediction, via threading. Easy to use....
DITHIOTHREITOL, 150UMOL, 1 EA. Dithiothreitol (DTT), 0.1 M Solution:, *0.1 M solution of DTT in high purity dH2O., *0.2 m filtered., *Storage: -20C. Category: SEQUENASE....
Biology Products: