Navigation Links
Experimental chemotherapy regimen shows promise in treating advanced lung cancer
Date:8/11/2008

PHILADELPHIA A combination of chemotherapy agents that have been tested in other tumor types appears to be a promising alternative to standard treatment for advanced non-small cell lung cancer, according to a report in the August 15 issue of Clinical Cancer Research, a journal of the American Association for Cancer Research.

In a phase II multicenter study of 56 patients with an advanced form of this common lung cancer, endpoints including response rate, progression-free survival, and overall survival from use of S-1 and irinotecan were similar to, or better than, those reported from standard treatment with platinum-based chemotherapy regimens.

Because the study had only a single arm meaning all patients received the experimental therapy the researchers cannot say if this regimen offers more benefit than standard treatment. But they did report that side effects resulting from the experimental therapy appeared to be much less severe than those typically seen with standard treatment.

"There continues to be reluctance on the part of both patients and treating physicians to accept the toxicity of platinum-based therapy, given the associated small gain in survival, so active therapies with improved toxicity profiles are clearly needed," said the study's lead investigator, Isamu Okamoto, M.D., Ph.D., associate professor in the Department of Medical Oncology at the Kinki University School of Medicine in Osaka, Japan.

Okamoto says that a direct comparison between this experimental regimen and platinum-based "doublet" chemotherapy should be conducted to confirm what appears to be a survival benefit among patients who used S-1 and irinotecan.

S-1 (also known as TS-1) is approved for use in Japan and Korea, where it has shown substantial benefit in treating gastric cancer, but is still in clinical trials in other countries, including the U.S. and Europe.

The multifaceted agent, which is available in capsule
'/>"/>

Contact: Jeremy Moore
Jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

1

GOOD

Page: 1 2

Related biology news :

1. Experimental Biology 2008 meets in San Diego April 5-9
2. Translational research patented first experimental treatment against idiopathic pulmonary fibrosis
3. Experimental Biology and Medicine announces expansion into Asia, opens new office
4. UC health news: molecular pathway may predict chemotherapy effectiveness
5. A search for protection against chemotherapy cardiotoxicity
6. New chemotherapy combo produces side effects, but no extra efficacy, in early breast cancer patients
7. Mitochondrial cholesterol makes response to chemotherapy difficult in hepatic cancer
8. Research shows skeleton to be endocrine organ
9. Clones on task serve greater good, evolutionary study shows
10. Study shows link between alcohol consumption and hiv disease progression
11. Novel 3-D cell culture model shows selective tumor uptake of nanoparticles

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/24/2009)...us Research Institute (LRI) today named 12 new gra...million, recognize innovative work across a broad ...their creativity, novelty, and potential to drive ... and cure the complex disease of systemic lupus. ,...lupus researchers across the nation and include in...
(Date:11/24/2009)...sts have crystallised a protein that may help gut ...rotein could be used by probiotic producers to ide...t to people. , "Probiotics need to interact with ...and if they attach to surfaces in the gut they are...their activity," says Dr Nathalie Juge from the In...
(Date:11/24/2009)...mic-level action of a remarkable class of ring-sha...rs with the Lawrence Berkeley National Laboratory ...ystallography beamline at the Advanced Light Sourc...n gene expression and replication, and are vital t... infectious agents, such as the human papillomavir...
Breaking Biology News(10 mins):Lupus Research Institute announces 2009 novel research grants 2Lupus Research Institute announces 2009 novel research grants 3A sticky solution for identifying effective probiotics 2Atomic-level snapshot catches protein motor in action 2Atomic-level snapshot catches protein motor in action 3Atomic-level snapshot catches protein motor in action 4HerbalScience Research Demonstrates that Optimized Turmeric Extract Inhibits Amyloid Beta Accumulation a Hallmark of Alzheimers Disease 56123 1HerbalScience Research Demonstrates that Optimized Turmeric Extract Inhibits Amyloid Beta Accumulation a Hallmark of Alzheimers Disease 56123 2HerbalScience Research Demonstrates that Optimized Turmeric Extract Inhibits Amyloid Beta Accumulation a Hallmark of Alzheimers Disease 56123 3Oncothyreon to present at Rodman Renshaw Global Healthcare Conference 13822 1Echo Therapeutics to Present at Rodman 26 Renshaw 2009 Annual Global Investment Conference 56117 1Echo Therapeutics to Present at Rodman 26 Renshaw 2009 Annual Global Investment Conference 56117 2
...ists have discovered that autoimmunity can be trig...ells develop, if T cells fail to recognize just on...The research confirms an emerging view that autoim...em, and not only at the sites where autoimmune dis...type 1 diabetes, or the joints in rheumatoid arthr...
...y coral reefs provide their adjacent coasts with s...ami waves than do unhealthy or dead reefs, a Princ...ed by the tsunami that devastated the coastlines o...ists developed the first-ever computer model of a ...sing a volcanic island as an example. The model de...
...chers have discovered an isolated, self-sustaining...ons almost two miles deep beneath the surface in a...l community demonstrated to be exclusively depende...d one of the few ecosystems found on Earth that do...he discovery, appearing in the October 20 issue of...
Other Biology News:Autoimmune disease triggered if T cells miss a single protein early on 2Autoimmune disease triggered if T cells miss a single protein early on 3Study: Living coral reefs provide better protection from tsunami waves 2Study: Living coral reefs provide better protection from tsunami waves 3Otherworldly bacteria discovered two miles down 2
(Date:11/25/2009)..., MARKHAM, ON, Nov. 25 /PRNewswire/ - Cytochroma...hD to its Board of Directors. Dr. Moldt will repla...on the Company,s Board. The number of Board member...very pleased to welcome Peter Moldt to the board a...and guidance as Cytochroma continues to make progr...
(Date:11/24/2009)...release is available in German . , Whether ...rds: RFID tags (Radio Frequency Identification) ar...e. They make it possible to label objects or goods...y. The appropriate scanner can read and process th... affixed to goods under production conditions of u...
(Date:11/24/2009)... , SANTA CRUZ, Calif., Nov. 24 /PRNewswire/ -...o Career Center, the nation,s leading online job b...ls. ,, Northwestern and Columbia University are...jor life science training Institutions. ,, The ...post-graduates in the life sciences. While there a...
(Date:11/24/2009)... Health care employment grew by... only one to show consistent growth during the U.S...als remain in trouble, and health systems are comi...nel, instead of just administrators. , ...care employment continued growing in October despi...
Breaking Biology Technology:Cytochroma Announces Appointment of Peter Moldt to Board of Directors 2Intelligence inside metal components 2Two Major Universities Join Nation's Leading Postgrad Bio Job Board 2The MedZilla Report for October 2009 - Health Care Employment Grows Again in October Even As Clinics, Specialty Centers Close 2The MedZilla Report for October 2009 - Health Care Employment Grows Again in October Even As Clinics, Specialty Centers Close 3The MedZilla Report for October 2009 - Health Care Employment Grows Again in October Even As Clinics, Specialty Centers Close 4
...e TopCount Microplate Scintillation and Luminescen...al assays involving both radionuclide and luminesc...TopCount for measuring a high energy beta emitter ...easurement technique that has the main advantage o...tail. Since cocktail is not required for measureme...
...ithKline Beecham Pharmaceuticals, UK , In...n the pharmaceutical industry that have resulted i...candidates, it has become vital that screening ass...m PerkinElmer Life Sciences has provided a platfor...can be automated. One such application is monitori...
...and ScintiPlates are popular platforms for running...llac MicroBeta effectively measures both plate typ...tomultiplier tubes, one above the sample and one b...and so MicroBeta measurements are conducted with t...roBeta with a Packard TopCount , an instrument th...
Other Biology Technology:Cerenkov Counting Performance on the TopCountTM Microplate Scintillation and Luminescence Counter 2Cerenkov Counting Performance on the TopCountTM Microplate Scintillation and Luminescence Counter 3Cerenkov Counting Performance on the TopCountTM Microplate Scintillation and Luminescence Counter 4Cerenkov Counting Performance on the TopCountTM Microplate Scintillation and Luminescence Counter 5Cerenkov Counting Performance on the TopCountTM Microplate Scintillation and Luminescence Counter 6Cerenkov Counting Performance on the TopCountTM Microplate Scintillation and Luminescence Counter 7Use of Novel FlashPlate Technology to Measure cAMP Accumulation in Chinese Hamster Ovary Cells Expressing Human -2 Adrenoreceptors 2Use of Novel FlashPlate Technology to Measure cAMP Accumulation in Chinese Hamster Ovary Cells Expressing Human -2 Adrenoreceptors 3Use of Novel FlashPlate Technology to Measure cAMP Accumulation in Chinese Hamster Ovary Cells Expressing Human -2 Adrenoreceptors 4Counting FlashPlates on the Wallac MicroBeta 2Counting FlashPlates on the Wallac MicroBeta 3
Vented Caps for 75 cm2 Flasks from BD Biosciences - Discovery Labware
BD BioCoat Poly-D-Lysine 60 mm Culture Dishes from BD Biosciences - Discovery Labware
BD Laminin 60 mm Culture Dishes from BD Biosciences - Discovery Labware
...incorporates the critical design features demanded...biomarker research. The Series 4000 delivers impro...nverting biomarker discoveries to biomarker assays...gned to fit into the research plans of any life sc...
Biology Products: