Navigation Links
Experimental Alzheimer's disease drugs might help patients with nerve injuries
Date:4/13/2011

Drugs already in development to treat Alzheimer's disease may eventually be tapped for a different purpose altogether: re-growing the ends of injured nerves to relieve pain and paralysis. According to a new Johns Hopkins study, experimental compounds originally designed to combat a protein that builds up in Alzheimer's-addled brains appear to make crushed or cut nerve endings grow back significantly faster, a potential boon for those who suffer from neuropathies or traumatic injuries.

The new drugs target a protein known as "-Site amyloid precursor protein cleaving enzyme 1," or BACE1, which plays a key role in generating the amyloid protein plaques that are thought to gum up normal nerve signaling in the brain. Previous laboratory research showed that BACE1 also is involved in creating the insulation material known as myelin, which coats the projections that nerve cells extend to connect with each other, as well as generating a molecular cascade that causes these projections to degenerate when they're injured.

Based on these earlier findings, assistant professor of neurology Mohamed Farah, Ph.D., professor of neurology John Griffin, M.D., and their colleagues tried blocking the action of BACE1 to analyze the effect on injured axon projections. The researchers started their experiments with mice whose ability to make BACE1 had been genetically knocked out. After these animals' sciatic nerves were cut or crushed, the scientists closely watched what happened as the axons regenerated.

Compared to normal mice that make BACE1, the animals lacking this protein cleaned up the debris around the injury site significantly faster. Since this debris can inhibit regeneration, Farah and his colleagues expected that the axons would re-grow faster. Sure enough, the cut ends of the animals' nerve cells generated more new sprouts, which grew into extensions that reached their targets muscles or other nerve cells days faster than the mice that
'/>"/>

Contact: Christen Brownlee
cbrownlee@jhmi.edu
410-955-7832
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related biology news :

1. French scientist wins the Journal of Experimental Biology Outstanding Paper Prize
2. Survival in a Changing World: The Journal of Experimental Biology 2009 symposium
3. 40 minority scientists receive travel fellowships to Experimental Biology 2009 in New Orleans
4. Experimental treatment halts hypoxic-ischemic brain injury in newborns
5. Experimental treatments restore partial vision to blind people
6. Experimental drug shows promise against brain, prostate cancers
7. French scientist wins the Journal of Experimental Biology Outstanding Paper Prize 2009
8. Experimental vaccine protects monkeys against chikungunya
9. Selected highlights of the research being presented at the Experimental Biology 2010 meeting
10. Experimental treatment protects monkeys from lethal Ebola virus post-exposure
11. Flemish researchers provide the first experimental evidence of dynamic allostery in protein regulation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... it is related to ability that we already possess. ... melody more easily than learning how to hit a ... the Neural Basis of Cognition (CNBC)a joint program between ... a fundamental constraint in the brain that may explain ... the Aug. 28, 2014, issue of Nature , ...
(Date:8/27/2014)... of Utah biologist agan Sekercioglu, who campaigns to save ... highest science prize, which is similar to the U.S. ... researchers picked for 2014 the top awards by TUBITAK, ... researchers won the Science Award and two including ... to the Science Award but for scientists who are ...
(Date:8/27/2014)... what is described by the Volunteer Wildfire Services of ... Cape provincial government warned residents in certain parts of ... veld fires. A high veld fire danger rating ... coast in the Great Kei and Mnquma area. ... thunderstorms. The thunderstorms bring lightning strikes and subsequent ...
Breaking Biology News(10 mins):Pitt and Carnegie Mellon engineers discover why learning can be difficult 2Pitt and Carnegie Mellon engineers discover why learning can be difficult 3University of Utah biologist wins Turkey's top science prize 2
... scientists have received new funding for a research program ... economically feasible. The project is based on the serendipitous ... fish cages in Puerto Rico by the thousands. The ... fascinating habits such as their tendency to crawl in ...
... mussels and oysters are important vehicles for the ... undercooked. Vibrio species, including human pathogens, are particularly ... even after cleaning procedures, thus representing a potential ... are well known to affect the persistence of ...
... during the summer in Alaska waters, is one of the ... in the 1800s has now left us with only a ... different species from right whales seen in the North Atlantic ... areas and ecological parameters critical to the survival of this ...
Cached Biology News:New project aims to make large-scale lobster farms feasible 2New project aims to make large-scale lobster farms feasible 3Edible bivalves as a source of human pathogens: signals between vibrios and the bivalve host. 2Habitat use by North Pacific right whales, Eubalaena japonica, in the Bering Sea and Gulf of Alaska 2
(Date:8/27/2014)... 27, 2014 Reportlinker.com announces that a ... catalogue: Global Chelating Agents Market 2014-2018 ... About Chelating Agent A chelating agent is a ... metal ions, thereby forming a metal-ion complex. It ... on chemical processes, formulations, and the environment by ...
(Date:8/27/2014)... “We are honored to be named ... Thangaraj, CEO of Radiant Sage. “We are offering truly ... imaging corelab market to a different level. We ... to efficiently and effectively manage the massive amounts of ... analyzed and read by trained physicians. Being recognized by ...
(Date:8/27/2014)... -- Research and Markets has announced the ... Paper Industry Report 2014" report to their offering. ... Paper Industry Report 2014 is a professional and in-depth ... for pulp & paper industry. The report ... classifications, applications and industry chain structure. The enzyme for ...
(Date:8/27/2014)... (PRWEB) August 27, 2014 Riviera ... is announcing the creation of the Sancilio Scientific ... take the SCI’s philosophy of looking to nature ... and development actions are based on sound scientific ... Scientific Advisory Board provides a vehicle for SCI ...
Breaking Biology Technology:Global Chelating Agents Market 2014-2018 2Global Chelating Agents Market 2014-2018 3Global Chelating Agents Market 2014-2018 4Radiant Sage Named to CIOReview List of 100 Most Promising Technology Companies 2Global Enzyme for Pulp & Paper Industry Report 2014 2New Sancilio & Company, Inc. Scientific Board 2New Sancilio & Company, Inc. Scientific Board 3
... for Cancer Research (OICR) announced today it has enhanced ... called the IPDC Fund. The augmented program is designed ... stage technologies. "In the face of declining ... to offer greater support for the most promising Ontario-based ...
... Therapeutics, Inc. (CTI) (Nasdaq and MTA: CTIC) announced today ... 2011 Conference on Tuesday, March 15th at 3.30 PM ... Convention Centre, Milan, Italy.Bio Europe Spring 2011CTI Presentation: Tuesday, ... AM PSTRoom Yellow 2, Milano Convention Centre (MIC) Media ...
... This release is available in German . ... which make them promising candidates for optoelectronic components. However, ... or influence their optic and electronic properties. A team ... at the Technische Universitaet Muenchen and member of the ...
Cached Biology Technology:Ontario Institute for Cancer Research Announces Enhancements to its Intellectual Property Development and Commercialization Program 2Ultra fast photodetectors out of carbon nanotubes 2
Mouse monoclonal [GB3] to Kalinin ( Abpromise for all tested applications). entrezGeneID: 3918 SwissProtID: Q13753...
Rabbit polyclonal to Tryptophanyl tRNA synthetase ( Abpromise for all tested applications). Antigen: Recombinant full length protein (Human): Tryptophanyl tRNA synthetase Entrez Gene ID: 745...
Mouse monoclonal [CIa] to Ia Antigen (Biotin) ( Abpromise for all tested applications)....
RNA polymerase sigma 70 Immunogen: Recombinant, full length protein. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Biology Products: