Navigation Links
Experiment finds ulcer bug's Achilles' heel
Date:12/10/2012

Experiments at the U.S. Department of Energy's (DOE) SLAC National Accelerator Laboratory have revealed a potential new way to attack common stomach bacteria that cause ulcers and significantly increase the odds of developing stomach cancer.

The breakthrough, made using powerful X-rays from SLAC's Stanford Synchrotron Radiation Lightsource (SSRL), was the culmination of five years of research into the bacterium Helicobacter pylori, which is so tough it can live in strong stomach acid. At least half the world's population carries H. pylori and hundreds of millions suffer health problems as a result; current treatments require a complicated regimen of stomach-acid inhibitors and antibiotics.

"We were looking for a means to disrupt H. pylori's own mechanism for protecting itself against stomach acid," said Hartmut "Hudel" Luecke, a researcher at the University of California, Irvine, and principal investigator on the paper, published online Dec. 9 in Nature. With this study, he said, "We have deciphered the three-dimensional molecular structure of a very promising drug target."

Luecke and his team zeroed in on tiny channels that H. pylori uses to allow in urea from gastric juice in the stomach; it then breaks this compound into ammonia, which neutralizes stomach acid. Blocking the channels would disable this protective system, leading to a new treatment for people with the infection.

Solving the structure of the protein to find the specific area to target wasn't easy. The channels are formed by the protein embedded in the bacterium's cell membrane, and membrane proteins are notoriously difficult to crystallize, which is a prerequisite for using protein crystallography, the main technique for determining protein structures. This technique bounces X-rays off of the electrons in the crystallized protein to generate the experimental data used to build a 3-D map showing how the protein's atoms are
'/>"/>

Contact: Andy Freeberg
afreeberg@slac.stanford.edu
650-926-4359
DOE/SLAC National Accelerator Laboratory
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Experiments may understate plant responses to climate
2. Foundational concept of ecology tested by experiment
3. Nicole George wins 2012 Journal of Experimental Biology Outstanding Paper Prize
4. MIT research: Study finds room to store CO2 underground
5. Study finds circle hooks lower catch rate for offshore anglers
6. LSUHSC research finds HPV-related head & neck cancers rising, highest in middle-aged white men
7. Head and body lice appear to be the same species, genetic study finds
8. Study finds peoples niceness may reside in their genes
9. Large international study finds memory in adults impacted by versions of 4 genes
10. Improved loblolly pines better for the environment, study finds
11. NIST/UMass study finds evidence nanoparticles may increase plant DNA damage
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Experiment finds ulcer bug's Achilles' heel
(Date:8/22/2014)... In 2015, American consumers will finally be able to ... Although touted as zero-emissions vehicles, most of the cars ... fossil fuel that contributes to global warming. , Now ... device that uses an ordinary AAA battery to produce ... electric current through two electrodes that split liquid water ...
(Date:8/21/2014)... A new study of American singles found that ... the highest orgasm rates. On average, men experience ... sexual orientation making little difference. For women, however, ... experience orgasm 62.9 percent of the time during ... pattern varies with women,s sexual orientation, with lesbian ...
(Date:8/21/2014)... skin fungus linked to dandruff, eczema and other itchy, ... even further global reachesincluding Hawaiian coral reefs and the ... , A review in the scientific journal PLOS ... the fungi of the genus Malassezia in ... datasets from around the world. , University of Hawai,i ...
Breaking Biology News(10 mins):Stanford scientists develop a water splitter that runs on an ordinary AAA battery 2Stanford scientists develop a water splitter that runs on an ordinary AAA battery 3Orgasm rates for single women less predictable than men's, vary by sexual orientation 2Orgasm rates for single women less predictable than men's, vary by sexual orientation 3Orgasm rates for single women less predictable than men's, vary by sexual orientation 4From dandruff to deep sea vents, an ecologically hyper-diverse fungus 2
... entities conducting research in synthetic biology worldwide grew significantly ... of an interactive map produced by the Synthetic Biology ... The map is available online at http://www.synbioproject.org/map . ... the design and construction of new biological parts and ...
... Centers for Disease Control, about one in six Americans gets ... of raw oysters in the U.S. are estimated to cost ... of health risk from eating raw oysters, Texas A&M University ... scientist Dr. Suresh Pillai and a team of researchers from ...
... 2013 Signal Hill, CA Bowman Design Group, an ... exhibits, and event marketing, is the first and only ... certification from FAMAB, the German exhibition and events industry ... established that the company met or exceeded goals set ...
Cached Biology News:Synthetic biology research community grows significantly 2Electron-beam pasteurization of raw oysters may reduce viral food poisoning 2Electron-beam pasteurization of raw oysters may reduce viral food poisoning 3Bowman Design Group is first US company awarded German FAMAB 'Sustainable Company' certification 2
(Date:8/22/2014)... 22, 2014 Research and Markets ... Biology Enzymes, Kits, & Reagents (Cloning, Epigenetics, PCR, Restriction ... to their offering. The global molecular ... 2013, and is expected to grow at a CAGR ... biology enzymes, kits, & reagents find applications in a ...
(Date:8/21/2014)... , Aug. 21, 2014  BioSpecifics Technologies ... company developing first in class collagenase-based products marketed ... CCH) in the U.S. and XIAPEX ® ... results from a randomized, double-blind Phase 2a study ... or edematous fibrosclerotic panniculopathy. The results showed that ...
(Date:8/21/2014)... , August 21, 2014 ... http://www.researchandmarkets.com/research/3zh3q8/global_hormone ) has announced the addition of ...  report to their offering.       ... as hormone therapy, is a means of ... produced by the body. This type of ...
(Date:8/21/2014)... , Aug. 21, 2014 Mathematic studies at the ... University , and funded by the Jeffrey Epstein VI ... tumors can be visually identified for elimination. These aggressive cells ... study, which shows a topological map of what to look ... cancer research, for while tumor cells can be extracted from ...
Breaking Biology Technology:Global Molecular Biology Enzymes, Kits, & Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) Market - Forecast to 2018 2Global Molecular Biology Enzymes, Kits, & Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) Market - Forecast to 2018 3BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 2BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 3BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 4BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 5Global Hormone Replacement Therapy Market 2014-2018: Key Vendors are Actavis, Bayer, Merck & Co, Novartis and Novo Nordisk 2Science Power Jeffrey Epstein and Harvard University Fund Project to Visually Stop Tumor Growth 2
... GeoPharma, Inc. (Nasdaq:,GORX) (the "Company") announced today in an ... audience as possible it has placed both of the ... at, http://www.GeoPharmainc.com under the "Analyst Coverage" tab in ... publicly several times in,the next few months., In ...
... Rigel,Pharmaceuticals, Inc. (Nasdaq: RIGL ) today announced that ... is scheduled to present,a company overview at the BIO ... February 11 at 11:45 a.m. EST., To access ... on to http://www.rigel.com . Please connect to Rigel,s ...
... Feb. 6 Cell Therapeutics, Inc. (CTI),(Nasdaq: CTIC ; MTAX) management will ... at 1:15 PM in the West Foyer,of the Waldorf-Astoria Hotel., The presentation ... The webcast can be accessed at, http://www.cticseattle.com ., , ... BIO CEO & Investor Conference ...
Cached Biology Technology:Recent Research Reports and Near-Term Corporate Events 2Recent Research Reports and Near-Term Corporate Events 3
... Time- and temperature-controlled microwave oven ... and Antigen Retrieval of formalin-fixed, ... ease of use, high throughput ... high performance. When used in ...
... reagents and supplies, for 10 chips, ... to perform protein analysis with 10 ... system. Supplied are 3 x 520 ... stain, 60 microliters Pro260 ladder (10-260 ...
...
... submicron range are part of your production ... of particle size is important to you. ... detect the component populations in your sample ... Analyzer uses Photon Correlation Spectroscopy (PCS) , ...
Biology Products: