Navigation Links
Expanding the range of nature's catalysts for industrial applications
Date:1/30/2014

Troy, N.Y. To make paper, manufacturers must break down cellulose (chunks of wood pulp), a process that currently requires large amounts of energy and toxic chemicals like chlorine. Nature performs the same task using enzymes, non-toxic biodegradable proteins that accelerate chemical reactions using far less energy. The catch is that the enzymes required for the job, in this case xylanases, don't hold up to the high temperatures of the manufacturing process. This is only one of many examples of how the limitations of enzymes hamper the development of elegant solutions in the manufacture of everything from medicine to detergents.

"So the question is: can we improve on nature?" said George Makhatadze, a chaired professor in the Biocomputation and Bioinformatics research constellation, professor of biological sciences, and member of the Center for Biotechnology and Interdisciplinary Studies (CBIS) at Rensselaer Polytechnic Institute. "Can we take an existing protein and, using computation, redesign it to withstand higher temperatures?"

Makhatadze designs "custom proteins," and is an expert in the critical interaction between electrical charges on the surface of proteins. Within the School of Science, Makhatadze's research is part of an interdisciplinary theme of modeling, analysis, and simulation. His research is also part of a CBIS research focus on protein engineering. In a 2009 edition of the Proceedings of the National Academy of Science (PNAS), his lab presented a computer model that enhances protein thermostability, while retaining full enzymatic activity. Now, with the support of a five-year, $1.7 million National Science Foundation grant, Makhatadze will investigate the speed of protein folding.

Enzymes are composed of long strings of amino acids. As the string is assembled, electrostatic forces along its length interact, causing it to twist and turn, and ultimately fold into a stable three-dimensional shape. The enzyme function
'/>"/>

Contact: Mary Martialay
martim12@rpi.edu
Rensselaer Polytechnic Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Expanding research communities and collaborations
2. Mobile LIDAR technology expanding rapidly
3. Parasites of Madagascars lemurs expanding with climate change
4. Site-specific, long-term research expanding understanding of climate change
5. Parents seen as critical stakeholders in expanding newborn screening
6. LABS, Inc. Launches Suite of Next-Generation Test Offerings; Focuses on Expanding Complex Biologic Testing Portfolio in 2012
7. Study shows large carnivore numbers and range declining worldwide
8. Control malaria by segmenting sleeping arrangements
9. Wide range of differences, mostly unseen, among humans
10. How chewing gum or a shed hair can let strangers read your Book of Life
11. Immunohistochemistry effectively detects ALK rearrangement
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... Using spider toxins to study the proteins that let ... say they have stumbled upon a biological tactic that ... insect plagues in a safe and environmentally responsible way. ... be lethal for one species and harmless for a ... target specific pests without harming beneficial species like bees. ...
(Date:7/10/2014)... , June 30, 2014  Aware, Inc. (NASDAQ: ... software and services, previously announced on June 26, 2014 ... cash dividend of $1.75 per share, or approximately $40 ... of July 10, 2014 and a payment date of ... NASDAQ that it had set an ex-dividend date for ...
(Date:7/10/2014)... 2014 According to the new ... And Area), Material (Optical Prism, Pizeoelectric, Capacitive, and Adhesives), ... Banking & Finance), and Geography - Global Trends & ... global Fingerprint Sensors Market is projected to cross $14.35 ... 16.8% from 2014 to 2020. Browse more ...
Breaking Biology News(10 mins):Potent spider toxin 'electrocutes' German, not American, cockroaches 2Potent spider toxin 'electrocutes' German, not American, cockroaches 3NASDAQ Sets Ex-Dividend Date for Aware, Inc.'s Special Cash Dividend of $1.75 Per Share 2Fingerprint Sensors Market worth $14.35 Billion by 2020 2Fingerprint Sensors Market worth $14.35 Billion by 2020 3
... St. Jude Children,s Research Hospital have reported details of ... enzyme essential for the influenza virus, replication. Since all ... researchers believe their findings will yield drugs that can ... be resistant to current antiviral treatments. When new ...
... State University suggest that a "fight" between bacteria normally living ... another type of bacteria, may be linked to two types ... continues after the instigator bacteria have been cleared by the ... GSU Center for Inflammation, Immunity and Infection. That fight can ...
... UCLA stem cell researchers have found for the first ... endothelium, the place where blood stem cells are made ... lack of one transcription factor, a type of gene ... the precursors that normally generate blood stem and progenitor ...
Cached Biology News:Target for potent first-strike influenza drugs identified 2Target for potent first-strike influenza drugs identified 3Target for potent first-strike influenza drugs identified 4Embryonic blood vessels that make blood stem cells can also make beating heart muscles 2Embryonic blood vessels that make blood stem cells can also make beating heart muscles 3
(Date:7/10/2014)... Ceres, Inc . (Nasdaq: CERE ), an ... for the three months ended May 31, 2014 and ... reported that the company and its customers have made ... Brazil, which concluded in June, despite dry and hot ... part of the growing season. Yields of several of ...
(Date:7/10/2014)... PNAS (Proceedings of the National Academy of Sciences) ... deprivation have a significant effect on our metabolism. The ... time of day to test for diseases such as ... , Researchers from the University of Surrey and The ... sleep deprivation, body clock disruption and metabolism, and discovered ...
(Date:7/10/2014)... even geckos and spiders can sit upside down forever. Nanophysics ... demonstrated this in an article just published in Physical ... benefit. , Geckos and spiders that seem to be able ... fascinated researchers worldwide for many years. We will soon be ... way as the gecko,s foot. But the fact is, sooner ...
(Date:1/15/2014)... akin to assembling a club sandwich at the ... researchers have succeeded in crafting a uniform, multi-walled ... foam commonly used in upholstered furniture and other ... polyurethane foam was reduced 35 percent compared with ...
Breaking Biology Technology:Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9Time of day crucial to accurately test for diseases, new research finds 2Even geckos can lose their grip 2Layered security: Carbon nanotubes promise improved flame-resistant coating 2
... Jan. 20, 2011 MedImmune,s Oncology group announced today ... broadly suppresses pathways that have been shown to play ... many solid tumors. The study, published in the February ... of the American Association for Cancer Research), suggests that ...
... Harriet L. Robinson, Ph.D., Chief Scientific Officer at GeoVax Labs, ... company that creates, develops and tests innovative HIV/AIDS vaccines, is ... Community Awards.  Dr. Robinson will be honored at the GaBio ... Atlanta,s Fox Theater. Dr. Robinson is the developer ...
... 2011 Reportlinker.com announces that a new market ... Hospital General Radiology Census ... is the most comprehensive European market report on ... IT systems (PACS) in European hospitals. Hospitals are ...
Cached Biology Technology:Investigational Compound Offers Novel Anti-IGF Approach To Inhibit Growth of Cancer Cells 2Investigational Compound Offers Novel Anti-IGF Approach To Inhibit Growth of Cancer Cells 3GeoVax Labs CSO Dr. Harriet L. Robinson to be Honored at 2011 Georgia Bio (GaBio) Community Awards Ceremony 2GeoVax Labs CSO Dr. Harriet L. Robinson to be Honored at 2011 Georgia Bio (GaBio) Community Awards Ceremony 3Reportlinker Adds Hospital General Radiology Census 2
... UNOsphere ion exchange ... supports with high binding ... support is a strong ... particle size of 120 ...
...
... Polyclonal Antibody against Aph-1a (Aph-1aL,S Loop ... gamma secretase is a multiprotein complex ... Pen-2; all four proteins are necessary ... secretase complex catalyzes cleavage of a ...
... Monoclonal Antibody Epitope: A ... Recommended Storage: Store vial ... contents and freeze at -20 C or below ... and thawing. Centrifuge product if not completely ...
Biology Products: