Navigation Links
Exercise rescues mutated neural stem cells
Date:7/5/2013

re neurons, which are the basic functional unit in the brains of humans and other animals. Mature neurons normally have a very complex morphology, allowing them to create networks in the brain which are important for processing information. Neurons with the mutant form of CHD7, however, seem to be incapable of forming networks.

Most strikingly, Liu and colleagues found that exercise fully rescued this phenotype in the hippocampus, the core region of the brain responsible for learning and memory. They allowed the CHD7 deficient animals to exercise on a running wheel, which rodents love to do. After the running exercise the CHD7 mutant neurons were fully rescued: They were able to create functioning networks.

That running causes a dramatic increase in neurogenesis in adults has been confirmed in animals and humans. "We were extremely excited to see that the CHD7 deficiency in a cell can be bypassed via an unknown mechanism provoked by exercise involving running. Now, we are eagerly working to find the underlying mechanism," says Haikun Liu. The neuroscientist believes this discovery will lead to a better understanding of the disease, possibly even pointing to a way to reactivate the CHD7 pathway and thus to attenuate CHARGE symptoms in human patients.

CHD7 is also an important cancer-related gene; many different types of human cancers, including lung cancer, colon cancer and brain tumors exhibit mutations in the molecule. The mechanism identified here provides a clear explanation: A mutation in CHD7 leads to a blockage of differentiation in stem cells, which is a major cause of tumorigenesis.

In addition, CHD7 has been identified as a high-risk gene in human autism, and many CHARGE patients are autistic. It seems that the gene is important in the regulation of many more physiological processes in the body. By analogy to the neural stem cell study, the DKFZ researchers will now use their advanced mouse model to investigate CHD7's
'/>"/>

Contact: Dr. Sibylle Kohlstädt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Total amount of exercise important, not frequency, research shows
2. Gene offers an athletes heart without the exercise
3. Exercise for stroke patients brains
4. Epigenetic biomarkers may predict if a specific diet and exercise regimen will work
5. Serotonin mediates exercise-induced generation of new neurons
6. Exercise or make dinner? Study finds adults trade one healthy act for another
7. Amiigo Unveils Fitness Tracker That Knows What Exercise Youre Performing
8. For those short on time, aerobic, not resistance, exercise is best bet for weight, fat loss
9. Exercise is smart for your heart - and makes you smarter
10. Exercise boosts satisfaction with life, researchers find
11. American Physiological Societys latest conference focuses on integrative biology of exercise
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... This news release is available in German . ... has evolved to recognize and respond to threats to ... disease. A detailed understanding of the mechanism underlying immunologic ... of research have converged to support the hypothesis that ... of immune cells with stem-cell-like potential. Until now, there ...
(Date:7/24/2014)... virus living inside your gut that has gone undetected ... researchers at San Diego State University has found that ... a newly described virus, named crAssphage, which infects one ... Bacteroidetes . This phylum of bacteria is thought to ... The research appears today in Nature Communications ., ...
(Date:7/23/2014)... that early reading skill might positively affect later intellectual ... , was conducted by researchers at the University of ... an ability that can be improved, our findings have ... research fellow in psychology at the University of Edinburgh, ... might aid not only the growth of literacy, but ...
Breaking Biology News(10 mins):Experiments prove 'stemness' of individual immune memory cells 2Experiments prove 'stemness' of individual immune memory cells 3Newly discovered gut virus lives in half the world's population 2Newly discovered gut virus lives in half the world's population 3Stronger early reading skills predict higher intelligence later 2
... revelations from door-to-door interviews, Stanford University geographer Eric Lambin ... give rise to a broad range of land-use challenges ... of Lyme disease in Belgium. For decades, orbiting ... surface of the Earth, giving scientists an unprecedented view ...
... COLUMBUS, Ohio The wasting disease associated with ... can also cause significant damage to the heart, new ... by muscle wasting and dramatic weight loss, was believed ... study showed that the condition reduces heart function and ...
... Winners of an international competition organized at Penn State ... announced today. The winners, whose awards include a share ... group of awardees in a series of competitions organized ... by Daniel Cosgrove, the Eberly Chair of Biology at ...
Cached Biology News:Stanford land-use expert brings satellite data down to Earth 2Stanford land-use expert brings satellite data down to Earth 3Stanford land-use expert brings satellite data down to Earth 4Muscle wasting in cancer does not spare the heart 2Muscle wasting in cancer does not spare the heart 3Winners of plant-biology video contest announced -- new competition begins at Penn State University 2
(Date:7/23/2014)... 2014 Lyfebulb, the International Pemphigus Pemphigoid ... NASDAQ OMX First North Premier, Stockholm ... a collaboration to increase awareness of unmet needs ... event attended by more than sixty patients, physicians, ... health and wellness company dedicated to serving the ...
(Date:7/23/2014)... Inc. (NASDAQ: SGMO ) today reported its ... For the second quarter ended June 30, 2014, ... or $0.10 per share, compared to a net loss ... same period in 2013. As of June 30, 2014, ... interest receivable of $236.7 million. Revenues for ...
(Date:7/23/2014)... Filippov (MIPT and Russian Quantum Center at Skolkovo) ... Republic, and the Institute of Physics in Bratislava, ... entanglement of particles passing through an amplifier and, ... Details are provided in an article published in ... preprint). , Quantum entangled particles are considered to ...
(Date:7/23/2014)... July 23, 2014 /PRNewswire-iReach/ -- Think Drinks are a ... the long term. They are the first functional focus ... energy as an alternative to the temporary fix associated ... Indiegogo on July 29, 2014, with hopes to raise ... Photo - http://photos.prnewswire.com/prnh/20140723/129697 ...
Breaking Biology Technology:Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 2Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 3Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 4Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 5Sangamo BioSciences Reports Second Quarter 2014 Financial Results 2Sangamo BioSciences Reports Second Quarter 2014 Financial Results 3Sangamo BioSciences Reports Second Quarter 2014 Financial Results 4Sangamo BioSciences Reports Second Quarter 2014 Financial Results 5Sangamo BioSciences Reports Second Quarter 2014 Financial Results 6Sangamo BioSciences Reports Second Quarter 2014 Financial Results 7Sangamo BioSciences Reports Second Quarter 2014 Financial Results 8Sangamo BioSciences Reports Second Quarter 2014 Financial Results 9Scientists find way to maintain quantum entanglement in amplified signals 2Scientists find way to maintain quantum entanglement in amplified signals 3Scientists find way to maintain quantum entanglement in amplified signals 4truBrain Neuroscientists To Launch More Effective, Healthier Alternative To Energy Drinks On Indiegogo 2
... to Life this week launched a statewide petition drive against ... cloning for the purpose of creating a baby or cloning ... medical experiments, all human cloning is a threat to the ... Wisconsin Right to Life. , ,The petition drive, to ...
... at the Midwest Express Center inMilwaukee, Wisconsin, Berbee will ... Microsoft Windows NT(R) 4.0 environments to WindowsServer 2003. The ... platform that has been designed to meet the sophisticated ... , , ,"We are very pleased to have been ...
... always, these are general rules, and any good entrepreneur will ... time, in the last 3.5 years weve received about 1,500 ... 100 detailed reviews, and participated in or facilitated more than ... seven rules on avoiding mistakes, and a final reminder of ...
Cached Biology Technology:Anti-Cloning Petition Drive Launched in Wisconsin 2"For Angels Only...When to say No... 2"For Angels Only...When to say No... 3
... The ideal modular cleanroom for biological ... that require cleanliness (to Class 10/ISO ... precision-joined to create ultra-smooth surfaces that ... disinfect. One-inch radius corners simplify cleaning. ...
... enclosures are designed for ... other process gas to ... HEPA filtration, heating/cooling, humidification, ... also available, along with ...
... cleanroom for biological safety labs (BSL) ... (to Class 10/ISO 3) and easy ... ultra-smooth surfaces that are easy to ... corners simplify cleaning. Unique double-wall panel ...
... For the professional, student, or faculty researcher, ... will accelerate your research and improve the quality ... data is the edge that researchers using LI-COR ... 10 years. The 4300 System is a third ...
Biology Products: