Navigation Links
Exercise increases brain growth factor and receptors, prevents stem cell drop in middle age
Date:11/17/2008

encourage new neural cell growth but which decrease with age -- account for the drop in neurogenesis. Specifically, the study looked at whether a decrease in brain-derived neurotrophic growth factor leads to a decline in new neural stem cells.

Variables studied

The researchers trained young (3 months), adult (7 months), early middle-aged (9 months), middle-aged (13 months) and old (24 months) mice to run a treadmill for up to one hour a day.

The study tracked neurogenesis, age, exercise, serum corticosterone levels and brain-derived neurotrophic factor (BDNF) and its receptor TrkB levels in the hippocampus. The researchers focused on middle age as a critical stage for the decline of neurogenesis in the mice.

As expected, the study found that neurogenesis drops off sharply in middle-aged mice. For example, the number of neural progenitor and mitotic (dividing) cells in the hippocampus of middle-aged mice was only 5% of that observed in the young mice.

The researchers also found that exercise significantly slows down the loss of new nerve cells in the middle-aged mice. They found that production of neural stem cells improved by approximately 200% compared to the middle-aged mice that did not exercise. In addition, the survival of new nerve cells increased by 170% and growth by 190% compared to the sedentary middle-aged mice. Exercise also significantly enhanced stem cell production and maturation in the young mice. In fact, exercise produced a stronger effect in younger mice compared to the older mice.

How does this happen?

Based on these results, it appears that nerve growth factor has more to do with these findings than the corticosterone:

  • The middle-aged exercisers had more brain-derived neurotrophic factor and its receptor, TrkB, compared to the middle-aged mice that did not exercise. This suggests that exercise promotes the production of brain-derived neurotrophic fac
    '/>"/>

Contact: Christine Guilfoy
cguilfoy@the-aps.org
301-634-7253
American Physiological Society
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Previous abortions and exercise: Do they affect pregnancy?
2. Study may explain exercise-induced fatigue in muscular dystrophies
3. Recommendations for childrens exercise lacking say experts
4. During exercise, the human brain shifts into high gear on alternative energy
5. For insulin sensitive overweight patients, 1 session of exercise improves metabolic health
6. Exercise could be the hearts fountain of youth
7. Post-exercise caffeine helps muscles refuel
8. Brief, intense exercise benefits the heart
9. Mass. General study shows how exercise changes structure and function of heart
10. Exercise during pregnancy leads to a healthier heart in moms- and babies-to-be
11. Where college students live can impact their weight, eating and exercise habits
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/18/2014)... referred for evaluation of suspected genetic conditions, whole-exome ... percent, including detection of a number of rare ... according to a study appearing in JAMA ... with the American Society of Human Genetics annual ... coding regions of thousands of genes simultaneously using ...
(Date:10/17/2014)... available in German . ... few drugs. When treating overdoses, doctors are often limited to ... if there is a combination of drugs involved. So what ... swallows his grandmother,s pills? ETH professor Jean-Christophe Leroux from the ... an answer to this question. "The task was to develop ...
(Date:10/16/2014)... they are anything but sustainable: environmental damage to ... becoming increasingly evident. Despite their disadvantages, however, monocultures ... as the sole possibility of achieving higher yields ... Schmid, an ecology professor at the University of ... and forestry. After all, a new study carried ...
Breaking Biology News(10 mins):Whole-exome sequencing shows potential as diagnostic tool 2Emergency aid for overdoses 2Emergency aid for overdoses 3Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3
... ancient genes, scientists have for the first time reconstructed ... system. , The research was led by Joe Thornton, ... Center for Ecology and Evolutionary Biology, and will be ... How natural selection can drive the evolution of complex ...
... them study endangered whales ?autonomous hydrophones that can be deployed ... calls of different whale species. , Those efforts are leading ... of researchers of rare right whales swimming in the Gulf ... of a right whale in the Gulf of Alaska since ...
... generation of artificial bone may rely on a few ... of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) have ... scaffolding-like material that is four times stronger than material ... the investigational stages, variations of this substance could also ...
Cached Biology News:Evolution of 'irreducible complexity' explained 2Research tracks whales by listening to sounds 2Research tracks whales by listening to sounds 3Secrets of the sea yield stronger artificial bone 2Secrets of the sea yield stronger artificial bone 3Secrets of the sea yield stronger artificial bone 4
(Date:10/25/2014)... (PRWEB) October 24, 2014 Today, Nerium ... announced the winners of its “Reflect Your Youth” contest, ... not only seen a difference in their skin since ... a new outlook on life as a result of ... originated as an effort by Nerium International to inspire ...
(Date:10/25/2014)... NEW YORK , Oct. 24, 2014 ... Access Pharmaceuticals, Inc. (ACCP), a biopharmaceutical company advancing ... implemented a 1-for-50 reverse split of its common ... Friday, October 24, 2014. PlasmaTech,s common stock will ... number 72754H109 and temporary ticker symbol "ACCPD". After ...
(Date:10/22/2014)... NEW YORK , Oct. 22, 2014 ... growth in the in vitro diagnostic (IVD) test industry, ... Kalorama Information. The healthcare market researcher listed more than 25 ... that could be the future of IVD products. Kalorama details ... industry, The Worldwide Market for In Vitro Diagnostic ...
(Date:10/22/2014)... Shimadzu Scientific Instruments introduces its Open ... the pain management and clinical markets. The software increases ... by allowing users to highlight and review results that ... allows analysts to filter results by group or based ... eliminating the need to sift through analytes of no ...
Breaking Biology Technology:Nerium International™ Inspires Conversation About the Journey of Aging with “Reflect Your Youth” Contest 2PlasmaTech Biopharmaceuticals, Inc. Announces Reverse Stock Split, Ticker Change and Launches New Corporate Website 2Report: Radical New IVD Test Approaches Key To Growth 2Report: Radical New IVD Test Approaches Key To Growth 3Shimadzu Releases QuantAnalytics Open Access LCMS Software Package for Clinical Applications 2
... reduced and Semen Sexing Technology achieves, milestone, ... months ended June 30, 2009, Microbix Biosystems Inc. (TSX:MBX) announced ... quarter had a small sales retraction that was related to ... for continued growth in sales. , "The 22% sales growth ...
... , , ... SIAL ) today announced the acquisition of cheminformatics ... informatics software tools used for design, selection and procurement ... www.chemnavigator.com ) comprehensive suite of virtual screening ...
... , , , , ... SQNM ), today reported its financial results for the quarter ended June ... Second Quarter Results , , ... $12.8 million for the second quarter of 2008. The decrease from the comparable ...
Cached Biology Technology:Microbix Sales Grow 22% For Nine Months 2Microbix Sales Grow 22% For Nine Months 3Microbix Sales Grow 22% For Nine Months 4Microbix Sales Grow 22% For Nine Months 5Sigma-Aldrich Acquires ChemNavigator, Inc., to Provide Researchers With Industry-Leading Chemical Compound Selection and Procurement Services 2Sigma-Aldrich Acquires ChemNavigator, Inc., to Provide Researchers With Industry-Leading Chemical Compound Selection and Procurement Services 3SEQUENOM Reports Second Quarter 2009 Financial Results and Highlights 2SEQUENOM Reports Second Quarter 2009 Financial Results and Highlights 3SEQUENOM Reports Second Quarter 2009 Financial Results and Highlights 4SEQUENOM Reports Second Quarter 2009 Financial Results and Highlights 5SEQUENOM Reports Second Quarter 2009 Financial Results and Highlights 6SEQUENOM Reports Second Quarter 2009 Financial Results and Highlights 7SEQUENOM Reports Second Quarter 2009 Financial Results and Highlights 8SEQUENOM Reports Second Quarter 2009 Financial Results and Highlights 9SEQUENOM Reports Second Quarter 2009 Financial Results and Highlights 10
... Extracts are optimized for maximum packaging efficiencies ... high efficiency extracts (> 109 pfu/g with ... a library containing at least 5 ... extracts are made from a specially designed ...
... 6 delivers enhanced statistics and statistical ... quality improvement managers. As an accepted ... 6 simplifies statistics for novice users ... by experts. It offers a powerful ...
... Mouse anti-Yersinia pestis F1 antigen, Monoclonal ... ELISA: Use at an ... an assay dependent dilution. WB: Use ... molecular weight: 18 kDa. Not tested ...
...
Biology Products: