Navigation Links
Exercise increases brain growth factor and receptors, prevents stem cell drop in middle age
Date:11/17/2008

BETHESDA, Md. (Nov. 18, 2008) − A new study confirms that exercise can reverse the age-related decline in the production of neural stem cells in the hippocampus of the mouse brain, and suggests that this happens because exercise restores a brain chemical which promotes the production and maturation of new stem cells.

Neural stem cells and progenitor cells differentiate into a variety of mature nerve cells which have different functions, a process called neurogenesis. There is evidence that when fewer new stem or progenitor cells are produced in the hippocampus, it can result in impairment of the learning and memory functions. The hippocampus plays an important role in memory and learning.

The study, "Exercise enhances the proliferation of neural stem cells and neurite growth and survival of neuronal progenitor cells in dentate gyrus of middle-aged mice," was carried out by Chih-Wei Wu, Ya-Ting Chang, Lung Yu, Hsiun-ing Chen, Chauying J. Jen, Shih-Ying Wu, Chen-Peng Lo, Yu-Min Kuo, all of the National Cheng Kung University Medical College in Taiwan. The study appears in the November issue of the Journal of Applied Physiology, published by The American Physiological Society.

Rise in corticosterone or fall in nerve growth factor?

The researchers built on earlier studies that found that the production of stem cells in the area of the hippocampus known as the dentate gyrus drops off dramatically by the time mice are middle age and that exercise can slow that trend. In the current study, the researchers wanted to track these changes in mice over time, and find out why they happen.

One hypothesis the researchers investigated is that the age-related decline in neurogenesis is tied to a rise in corticosterone in middle age. Elevation of corticosterone has been associated with a drop in the production of new stem cells in the hippocampus.

The second hypothesis is that nerve growth factors -- which
'/>"/>

Contact: Christine Guilfoy
cguilfoy@the-aps.org
301-634-7253
American Physiological Society
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Previous abortions and exercise: Do they affect pregnancy?
2. Study may explain exercise-induced fatigue in muscular dystrophies
3. Recommendations for childrens exercise lacking say experts
4. During exercise, the human brain shifts into high gear on alternative energy
5. For insulin sensitive overweight patients, 1 session of exercise improves metabolic health
6. Exercise could be the hearts fountain of youth
7. Post-exercise caffeine helps muscles refuel
8. Brief, intense exercise benefits the heart
9. Mass. General study shows how exercise changes structure and function of heart
10. Exercise during pregnancy leads to a healthier heart in moms- and babies-to-be
11. Where college students live can impact their weight, eating and exercise habits
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2013)... join together in a major new effort to educate ... providing Earth,s people with clean water that looms ahead ... comment article in the current edition of Chemical ... American Chemical Society (ACS), the world,s largest scientific society. ... and Jerald L. Schnoor, Ph.D., explain that shortages of ...
(Date:5/22/2013)... is responsible for legionellosis, an infectious disease that can ... pathogen has developed a complex method enabling it to ... avoiding these acting against the infectious bacteria. , Research ... in which teams from the National Institute of Health ... in Barcelona (BSC) have also participated, has described for ...
(Date:5/21/2013)... Biologists have known for a long time that some ... well understood, particularly for plants. But it may be ... Australian National University and the U. S. National Evolutionary ... published 21 May in the journal Nature Communications ... faster-changing genomes. , Drawing from a database of global ...
Breaking Biology News(10 mins):Mechanism discovered which aids Legionella to camouflage itself in the organism 2Small but speedy: Short plants live in the evolutionary fast lane 2
... Accurate duplication of genetic material and the faithful ... initiation of DNA replication is linked both to cell ... other "eukaryotes," the assembly of a multi-protein complex called ... initiation of DNA replication. As the name implies, origin ...
... ,PROVIDENCE, R.I. [Brown University] Seemingly healthy adults, if ... physiological consequences decades later. In research published online last ... led by psychiatrists at Brown University and Butler Hospital ... kids appear to have an elevated inflammatory response to ...
... Mont. -- Invasive plants make life tougher for farmers and ... Missouri River Basin, so why not turn the plants into ... Russian olive and saltcedar alone could supply biomass far into ... Converting invasive plants to fuel is an intriguing idea ...
Cached Biology News:Novel protein critical for cellular proliferation discovered 2Childhood adversity may lead to unhealthy stress response in adult life 2Childhood adversity may lead to unhealthy stress response in adult life 3Montana State, partners in 6 states consider converting invasive plants to fuel 2Montana State, partners in 6 states consider converting invasive plants to fuel 3Montana State, partners in 6 states consider converting invasive plants to fuel 4
(Date:5/22/2013)... The Conference Forum announced ... Advance Clinical Trials conference taking place on September 19-20 ... , Disruptive thinkers from Novartis, Pfizer, Eli Lilly, ... approaches to reduce expensive infrastructure, engage patients and generate ... be big, or novel, or it must change the ...
(Date:5/22/2013)... 2013  Empire Genomics announced today it has ... novel genomic biomarker from Cornell University for use ... help in diagnosing and determining treatment for patients ... Neuroendocrine prostate cancer (NEPC) is a lethal variant ... novo, but more commonly arises after hormonal therapy ...
(Date:5/22/2013)... CANTON, Mass. and NEW ORLEANS ... commercial leader in the field of regenerative medicine, presented ... expert economists from Analysis Group (a leading health economics ... that diabetic foot ulcers (DFU) and venous leg ulcers ... The results of this research, which reveal annual ...
(Date:5/22/2013)... -- Cleveland BioLabs, Inc. (NASDAQ: CBLI) today announced that the Company ... Microcap Conference, May 30, in New York, NY ... , CPA, Chief Financial Officer of Cleveland BioLabs, will present ... 1:30 p.m. Eastern Time.  A live and archived webcast of ... of the Cleveland BioLabs website at www.cbiolabs.com . ...
Breaking Biology Technology:Disruptive Innovation Hits Clinical Trials, Dedicated Event Launches 2Empire Genomics Licenses Novel DNA Biomarker for Use in Diagnosing and Creating a Companion Diagnostic Test for Neuroendocrine Prostate Cancer 2Organogenesis Presents Findings from Groundbreaking Research Highlighting the Healthcare Resource and Economic Burden of Venous Leg Ulcers and Diabetic Foot Ulcers 2Organogenesis Presents Findings from Groundbreaking Research Highlighting the Healthcare Resource and Economic Burden of Venous Leg Ulcers and Diabetic Foot Ulcers 3Organogenesis Presents Findings from Groundbreaking Research Highlighting the Healthcare Resource and Economic Burden of Venous Leg Ulcers and Diabetic Foot Ulcers 4Cleveland BioLabs to Present at Second Annual Marcum LLP Microcap Conference 2
... 14 Response Genetics, Inc.,(Nasdaq: RGDX ), ... June 30, 2007. "The second quarter of ... our successful initial public offering in June," said,Kathleen ... are very,pleased by the recent developments that have ...
... Year, - 17 Percent Quarter-to-Quarter Revenue Gain Evidences Start of Turnaround ... for Core Business ... - DelSite Signs Additional Agreements, IRVING, Texas, Aug. 14 Carrington,Laboratories, Inc. (Nasdaq: ... compared to $6.5 million in the year ago,period. The revenue in the quarter just ...
... NEW YORK, Aug. 14 Summertime equals fun ... with irritable bowel syndrome (IBS), typical,summer fare could ... Koff, author of "Recipes for IBS," has more ... summer months to prevent IBS from,ruining their celebrations. ...
Cached Biology Technology:Response Genetics Reports Second Quarter 2007 Financial Results 2Response Genetics Reports Second Quarter 2007 Financial Results 3Response Genetics Reports Second Quarter 2007 Financial Results 4Response Genetics Reports Second Quarter 2007 Financial Results 5Response Genetics Reports Second Quarter 2007 Financial Results 6Response Genetics Reports Second Quarter 2007 Financial Results 7Response Genetics Reports Second Quarter 2007 Financial Results 8Carrington Reports Second Quarter 2007 Results 2Carrington Reports Second Quarter 2007 Results 3Carrington Reports Second Quarter 2007 Results 4Carrington Reports Second Quarter 2007 Results 5Carrington Reports Second Quarter 2007 Results 6Carrington Reports Second Quarter 2007 Results 7
Formulation: 10mM PBS/500 mM NaCl, 0.09% NaN3, pH 7.2...
p27 rabbit polyclonal antibody...
Rabbit polyclonal to Shigella (HRP) ( Abpromise for all tested applications)....
Rabbit polyclonal to Aortic Elastin ( Abpromise for all tested applications). entrezGeneID: 2006 SwissProtID: P15502...
Biology Products: