Navigation Links
Exercise in a pill may protect against extreme heat sensitivity
Date:1/8/2012

when we gave it no more than 10 minutes before the activity," said Hamilton.

Further experiments showed that one target of AICAR is the skeletal muscle calcium release channel, RyR1. In muscle cells from mice with the mutant form of the ryanodine receptor, calcium "leaks" out of intracellular stores into the cytoplasm in response to a elevation in body temperature generating a feed-forward cycle of calcium lead and increased oxidative stress which drives additional calcium leak. Cytoplasmic calcium eventually reaches a level that triggers massive muscle contractions. These sustained muscle contractions lead to muscle breakdown and leakage of potassium and protein from the muscle, causing heart or kidney failure, and ultimately death.

"AICAR stops the feed forward cycle that triggers these sustained muscle contractions," said Hamilton. "We have shown that it acts directly on the ryanodine receptor to decrease the calcium leak. It also protects intracellular calcium stores from depletion and this contributes to the ability of this compound to slow muscle fatigue."

The finding has implications for young athletes and soldiers with abnormal heat sensitivity, especially those who must wear heavy gear that does not allow them to dissipate the heat generated with exercise.

While it would make sense to tell people with the genetic trait to avoid exercise in the heat, Hamilton said that many youngsters might ignore such advice.

"We were attempting to identify an intervention, something that could be used prophylactically to protect these sensitive individuals without significant side effects," she said.

More work is needed before she can determine if AICAR fits that bill, but the studies in mice are very encouraging.

Hamilton said that this work was truly a group effort involving the members of her laboratory and a number of critical collaborators, each author contributing an important part of the story.
'/>"/>

Contact: Graciela Gutierrez
ggutierr@bcm.edu
713-798-4710
Baylor College of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. For insulin sensitive overweight patients, 1 session of exercise improves metabolic health
2. During exercise, the human brain shifts into high gear on alternative energy
3. Recommendations for childrens exercise lacking say experts
4. Study may explain exercise-induced fatigue in muscular dystrophies
5. Previous abortions and exercise: Do they affect pregnancy?
6. Exercise increases brain growth factor and receptors, prevents stem cell drop in middle age
7. Exercise helps overweight children reduce anger expression
8. Fear of hypoglycemia a barrier to exercise for type 1 diabetics
9. Eating habits and exercise behaviors in children can deteriorate early
10. Exercise no danger for joints
11. Exercise after knee replacement critical
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2015)... SANTA CLARA, Calif. , Aug. 20, 2015 ... based company focused on improving the user experience ... voice and vision technologies, today announced that its ... and voice biometric authentication software to be ... Alliance tested TrulySecure for compliance with the FIDO ...
(Date:8/18/2015)... 17, 2015 Research and Markets ( ... "Global Biometric Authentication & Identification Market: Focus ... Forecast, 2015-2020" report to their offering. ... systems market is expected to grow at an ... and generate over $25 billion (approximately) by 2020 ...
(Date:8/12/2015)... YORK , Aug. 12, 2015  New ... hackers can attack Android phones to steal users, ... the increasing availability of fingerprint scanners on mobile ... utmost concern. To secure biometrics on mobile devices, ... to augment these convenient authentication systems with strong ...
Breaking Biology News(10 mins):TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 2TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 3TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 4TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 5Global Biometric Authentication & Identification Market 2015: Focus On Modality, Motility & Application - Estimation & Forecasts to 2020 for the $25 Billion Industry 2HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 2HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 3
... and researchers from across the Asia-Pacific gathered today for ... Asia-Pacific Osteoporosis Meeting, taking place at the Kuala Lumpur ... Deputy Minister of Health of Malaysia, YB Datuk Rosnah ... more than 60 nations. His Excellency Tun Dato, Seri ...
... parasite numbers in the stomachs of individual seabirds in the ... worms inside seabird stomachs and is an important step forward ... research is published today (13 December 2012) in the scientific ... research team trialled the use of endoscopy, often used in ...
... isolated cancer stem cells that lead to the growth of ... kidneys of young children. The researchers have used these cancer ... day might be used to treat some of the more ... in EMBO Molecular Medicine . "In earlier studies, ...
Cached Biology News:IOF Asia-Pacific Meeting presents new research and advances in osteoporosis management 2IOF Asia-Pacific Meeting presents new research and advances in osteoporosis management 3Scientists develop novel method to study parasite numbers in wild seabirds 2Scientists develop novel method to study parasite numbers in wild seabirds 3Cancer stem cells isolated from kidney tumors 2
(Date:8/26/2015)... , Aug. 26, 2015  Platform therapeutic company ... has received a $1.5M Phase II SBIR grant ... further develop its therapeutic agent to reduce arteriovenous ... in end stage renal disease (ESRD) patients undergoing ... Institute of Diabetes and Digestive and Kidney Diseases ...
(Date:8/26/2015)... and BEIJING , August 26, 2015 ... Scene with Impressive Acheivements  DiaCardio wins 1 st ... The competition, led in Israel ... featured 21 startups from countries including the US, China ... and Latin America .  Impressive ...
(Date:8/26/2015)... OXFORD, England , August 26, 2015 ... P2i Ltd against Europlasma NV relating to P2i ... parties have resolved their dispute in the United ... or liability on the part of either party. As a ... the Central District of California dismissed ...
(Date:8/26/2015)... Bruno, CA. (PRWEB) , ... August 26, 2015 , ... ... major conferences to develop new business relationships with local sponsors in southern California. The ... to facilitate their drug development processes and regulatory pathways., , ...
Breaking Biology Technology:Symic Biomedical Awarded $1.5MM NIH Phase II SBIR Grant to Develop its Proteoglycan Mimetic Therapeutics to Reduce Vascular Access Failures in ESRD 2Symic Biomedical Awarded $1.5MM NIH Phase II SBIR Grant to Develop its Proteoglycan Mimetic Therapeutics to Reduce Vascular Access Failures in ESRD 3Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 2Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 3Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 4Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 5Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 6P2i Settles United States Litigation 2PRC Clinical To Attend Major Industry Conferences And Meet Sponsor Companies In The San Diego Biotech Hub 2PRC Clinical To Attend Major Industry Conferences And Meet Sponsor Companies In The San Diego Biotech Hub 3
... Data , , THOUSAND OAKS, Calif., June 22 ... that the U.S. Food and Drug Administration (FDA) has asked ... Health Drugs Advisory Committee (RHDAC) on Aug. 13, 2009. The ... for denosumab, a RANK Ligand inhibitor for which Amgen is ...
... Pharmaceutical Research and Manufacturers of America ... statement regarding today,s AARP-White House press conference on health care ... we believe this agreement will be looked back in time ... our troubled health care system. Our $80 billion pledge ...
... COLUMBUS, Ohio, June 22 Mettler-Toledo International Inc. (NYSE: ... has been appointed to its Board of Directors, effective July ... and Chief Executive Officer of Millipore Corporation (NYSE: ... research and biopharmaceutical manufacturing industry. Prior to joining Millipore ...
Cached Biology Technology:Amgen to Participate in Reproductive Health Drugs Advisory Committee Meeting in August 2Amgen to Participate in Reproductive Health Drugs Advisory Committee Meeting in August 3Amgen to Participate in Reproductive Health Drugs Advisory Committee Meeting in August 4Amgen to Participate in Reproductive Health Drugs Advisory Committee Meeting in August 5Amgen to Participate in Reproductive Health Drugs Advisory Committee Meeting in August 6Amgen to Participate in Reproductive Health Drugs Advisory Committee Meeting in August 7PhRMA Statement on AARP-White House Press Conference 2Martin Madaus Joins Mettler Toledo Board of Directors 2
... save space and organize gloves, ... other garb. They are the ... small parts used in labs, ... Many other sizes and custom ...
... Quixell, manufactured by Stoelting, selects single ... control. In no time at all, a ... on the keypad...the cell is collected into ... individual wells of a microtiter plate. Quixells ...
... microRNA expression profiling and built on ... on-chip synthesis platform. These microarrays are ... microRNA Expression Profiling Service. ... Microarray contains all known fish microRNAs ...
... for genome-wide microRNA expression profiling and ... Paraflo microfluidic on-chip synthesis platform. These ... our comprehensive microRNA Expression Profiling Service. ... Maize microRNA Microarray contains all known ...
Biology Products: