Bethesda, Md. - Although exercise is generally considered to be a good thing for people with high blood pressure, it has traditionally been considered too risky for women who are also pregnant. Some studies suggest that exercise has benefits such as decreasing the risk of women developing preeclampsia, a condition that raises blood pressure to dangerously high levels but how this might happen has remained unknown. New research using an animal model falls into the "pro-exercise" camp: It suggests that exercise before conception and in the early stages of pregnancy may protect a mother-to-be by stimulating the expression of two proteins thought to play a role in blood vessel health.
The study was led by Jeffrey Gilbert of the University of Oregon's Department of Human Physiology, while he was with the University of Minnesota Medical School. Dr. Gilbert will present the research at the Physiology of Cardiovascular Disease: Gender Disparities conference, October 12 at the University of Mississippi in Jackson. The conference is sponsored by the American Physiological Society with additional support from the American Heart Association. His presentation is entitled, "Exercise Training Before and During Pregnancy Improves Endothelial Function and Stimulates Cytoprotective and Antioxidant Pathways in the Pregnant Rat."
In the study, female rats were separated into two groups, the exercise group and the control group, and later impregnated. The exercise group ran voluntarily on an activity wheel for six weeks prior to and during pregnancy, with running times and distances monitored weekly. The control group did not exercise. The team analyzed tissue samples taken from both groups late in their pregnancies.
The researchers found that the rats in the exercise group had higher levels of a circulating protein called vascular endothelial growth factor (VEGF) than those in the control group. VEGF and a pregnancy specific versi
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American Physiological Society