Navigation Links
ExcellGene and Khner achieved milestone in development of novel 250 Liter mammalian cell culture bioreactors
Date:5/13/2009

May 12, 2009 / b3c newswire / - ExcellGene SA, Monthey and Adolf Kühner AG, Birsfelden announce today that they achieved an important milestone in the development of a revolutionary cell culture technology for scale up and manufacturing from suspension cultured mammalian cells.

As part of a long-term partnership the two companies disclose today the successful conclusion of the technically challenging task of growing mammalian cells for the production of recombinant proteins in an orbitally shaken bioreactor.  The mechanism of orbital shaking allows for efficient mixing of suspension cultures, while oxygenating cells through the head space. The cylindrical vessel contains a disposable, sterile bag with appropriate connection tubes for seeding, feeding, gas supply and harvesting of the culture. Compared to classical stirred tank bioreactors, OrbShake-bioreactors are much simpler and less costly to operate.

The principles of orbital shaking technology with cylindrical vessels at smaller scale (50 ml to 10 Liter) has been object of preceding research and development at the two companies, and data obtained have shown that oxygen, the most important nutrient in animal cell culture, can be transferred to cells in such reactors as efficiently, if not more efficiently than any other bioreactor system used for animal cells so far. Cell culture data obtained from pilot experiments executed at ExcellGene have shown that growth and productivity from these reactors, now shown up to a scale of 200 Liters, are equivalent to those of fully instrumented non-disposable, glass or stainless steel stirred bioreactors.
 
“The top-class technical and developmental expertise of Kühner AG in shaking technology is providing the necessary hardware knowledge that will be needed to tackle the challenging task of creating a revolut
'/>"/>

b3c newswire

Page: 1 2 3

Related biology news :

1. A new milestone in the GMES Space Component Program successfully achieved
2. Milestone achieved toward production of malaria treatment using synthetic biology and fermentation
3. Secure Services Corp. Achieves Milestone in United States Identity Protection with the Launch of the SSC SHAPE Card Management Solution
4. A gentle touch for better control, a quantum mechanical con, and milestone PRL papers
5. Missouri Botanical Garden mounts milestone 6 millionth herbarium specimen
6. Gender, coupled with diabetes, affects vascular disease development
7. New target for anti-flu drug development
8. Selexis Announces Advanced Approach to Maximize Power of Genetic Elements for Rapid Development of High Performance Cell Lines
9. KAUST and American University in Cairo to collaborate on research and academic development
10. Old developmental pathways spawn revolutionary evolutionary changes
11. NIST announces 56 new awards for innovative technology research and development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/5/2014)... , Dec. 4, 2014 Increased emphasis ... investments in new testing and inspection technologies. The ... rise to a range of innovative test solutions. ... of Generation Y, which is generally more inclined ... result, product development strategies of test equipment vendors ...
(Date:12/3/2014)... GLENDALE, Ariz. , Dec. 2, 2014 ... biometric hand readers, Inception Technologies is pleased to announce ... it easier for customers to collect the workforce data ... the problems that have been left by existing readers. ... to user interface, connectivity and modern technology. Older models ...
(Date:11/21/2014)... Nov. 20, 2014 C-Labs LLC, a leading ... of Things (IoT), today announced the appointment of ... officer. Previously a strategic advisor to the firm, Mr. ... Mr. Traynor is based out of the C-Labs office ... to Chris Muench , Chief Executive Officer. ...
Breaking Biology News(10 mins):Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4Inception Technologies to Release New Biometric Reader 2C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2
... off on a sun-powered adventure this autumn when the Durham ... Challenge. Using nothing but solar power, the DUSC team ... of Australia to Adelaide in the south. The Durham ... in mid-August after taking part in endurance testing in the ...
... Milan, Italy, August 11, 2011 Memory is not a ... on different areas of the brain. Episodic memory, the ability ... is known to be vulnerable to brain damage involving the ... hippocampus occurs very early in life? In a case study ...
... Loligo bleekeri ) employ different reproductive strategies depending on their ... BMC Evolutionary Biology shows that the divergent mating ... different sperm sizes. Large male squid compete for females ... female has chosen her partner they mate in an above ...
Cached Biology News:Durham University solar car takes on World Solar Challenge 2When you can recite a poem but not remember who asked you to learn it a few days earlier 2
(Date:12/17/2014)... CASI Pharmaceuticals, Inc. (Nasdaq: CASI ... and commercialization of innovative therapeutics addressing cancer and other ... primary commercial focus on China , ... C meeting with the U.S. Food and Drug Administration ... February 2015.  During this meeting the Company will seek ...
(Date:12/15/2014)... METTLER TOLEDO is pleased to announce ... V19 with PVM technology , is now available. ... measurement tool continuously captures high-resolution images under a ... automatically prepares a report pairing the most relevant ... changes. This compelling blend of high resolution images ...
(Date:12/15/2014)... , Dec. 15, 2014  GlassesOff Inc. (OTCBB: GLSO) ... as an independent director of the Company,s Board ... AeroScout and served as its CEO until its acquisition ... a $240 million transaction. Recognized as the inventor of ... leadership, AeroScout provided Wi-Fi -based RFID solutions focused on ...
(Date:12/13/2014)... December 13, 2014 CanDiag, Inc., a ... company has changed its name to OncoTab, Inc. ... of where we are today,” said CEO and Chief ... platform’s applications beyond breast cancer diagnostics to include imaging ... of that evolution.” , Founded in 2011 by Dr. ...
Breaking Biology Technology:CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 2CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 3CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 4CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 5New Real-Time In Situ Probe-Based Video Microscope from METTLER TOLEDO 2AeroScout Founder Joins GlassesOff's Board of Directors 2AeroScout Founder Joins GlassesOff's Board of Directors 3CanDiag Inc. Expands Product Scope Under a New Name: OncoTab, Inc. 2
... , , , ... Transcriptor Reverse Transcriptase in,the Eberwine Target Preparation Workflow , ... , , Reproducibility and sensitivity are key parameters ... microarray,platforms has shifted the focus to target preparation as a,critical step in microarray ...
... , , ... , , Over the past decade, many organisms ... of gene sequences are now ready,for functional analysis. Knowledge of tissues and cells,that ... , , , , ...
... , , ... Roche Applied Science now offers new larger pack sizes,of PCR-Grade Nucleotides. These larger pack ... , , , Single dNTPs , ... , Single dNTPs are now available in 500-mol pack sizes.,The Deoxynucleoside ...
Cached Biology Technology:Increased Sensitivity in Microarray Analysis 2Increased Sensitivity in Microarray Analysis 3The DIG System Nonradioactive Automated,High-Throughput In Situ Hybridization:,a Powerful Tool for Functional Genomics Research 2The DIG System Nonradioactive Automated,High-Throughput In Situ Hybridization:,a Powerful Tool for Functional Genomics Research 3The DIG System Nonradioactive Automated,High-Throughput In Situ Hybridization:,a Powerful Tool for Functional Genomics Research 4The DIG System Nonradioactive Automated,High-Throughput In Situ Hybridization:,a Powerful Tool for Functional Genomics Research 5The DIG System Nonradioactive Automated,High-Throughput In Situ Hybridization:,a Powerful Tool for Functional Genomics Research 6PCR-Grade Nucleotides,Larger Pack Sizes Now Available 2
The PROTEAN II slab gel casting stand is a component of the PROTEAN II XL and xi casting apparatus. It is supplied with gaskets....
Mouse monoclonal [H4B4] to LAMP2 - Lysosome Marker (Phycoerythrin) ( Abpromise for all tested applications). entrezGeneID: 3920 SwissProtID: P13473...
... software for the microscopy market by ... components and peripherals with powerful archiving, ... intuitive interface simplifies workflow and speeds ... powerful features such as image stitching, ...
AVOID FREEZE/THAW CYCLES. Recognizes the ~32 kDa DNase IIα chain and the ~40 kDa proenzyme. DNase II causes both DNA condensation and DNA fragmentation. ...
Biology Products: