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Evolutionary medicine of skin cancer risk among Europeans
Date:9/17/2013

w, although this point needs to be further explored" says Santos Alonso, senior author of the paper.

Interestingly, the same allele V60L has been associated to increased risk of melanoma, the most dangerous of skin cancers. This indicates", says Saioa Lpez, one of the two main authors of the paper, "that the increase in fitness for the population as a consequence of depigmentation has had a collateral damage consequence for the individuals health. This can be reconciled if we assume that melanoma is typically a post-reproductive disease, and consequently should have little effect on the individual's genetic contribution to the next generation. It constitutes a kind of evolutionary 'buy now pay later' trade-off.'"


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Contact: Joe Caspermeyer
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Molecular Biology and Evolution (Oxford University Press)
Source:Eurekalert

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