Navigation Links
'Evolutionary forecasting' for drug resistance
Date:9/21/2009

he upcoming study, Shamoo's team will sequence the genome of each organism both before and after the test. In addition, they'll take daily samples of the bacteria from the vessel and hold onto those for analyses. The stored samples are essentially a fossil record of the organism's adaptation to the drug. Using these, investigators can piece together the molecular path to resistance.

To determine the order the mutations occurred in, the team will use a technique created by Rice's Sarah Wu, a Will Rice College senior majoring in biochemistry and cell biology who began working in Shamoo's lab as a freshman. Using an instrument called a mass spectrometer, Wu found a way to translate the molecular changes from a particular mutation to the molecular weights of samples analyzed with the mass spectrometer.

Shamoo said the technique is important because it will allow his team to determine which mutations occurred first and to build those changes into a network-style representation that show's how an organism adapts to a specific drug.

Once the team has identified the particular mutations that convey drug resistance, they'll use X-ray crystallography to try and determine the exact molecular modifications that occur in the proteins those genes encode.

"We're interested in building those physical relationships that show how molecules confer drug resistance," Shamoo said. "The idea is that if you understand the mutation and what the mutation does to an enzyme or protein, then you can understand how that helps increase the fitness of a population of bacteria."

Shamoo said the team hopes to find a general set of rules or patterns that bacteria follow as they evolve to become drug-resistant.

For example, while the specific mutations that allow bacteria to become drug-resistant may differ from strain to strain, there may be patterns or rules that govern the order in which mutations occur and the regions of genome in which they oc
'/>"/>

Contact: Jade Boyd
jadeboyd@rice.edu
713-348-6778
Rice University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Scientists use microRNAs to track evolutionary history for first time
2. Sex in the Caribbean: Environmental change drives evolutionary change -- eventually
3. New advance in revolutionary bullet fingerprinting technique
4. Key to evolutionary fitness: Cut the calories
5. DNA template could explain evolutionary shifts
6. Newly discovered snow roots are evolutionary phenomenon
7. Biologists devise unifying framework to explain evolutionary puzzles
8. Biologists consider unifying framework to explain evolutionary puzzles
9. U of Minnesota research reveals critical role of evolutionary processes in species coexistence
10. The evolutionary foundation of genomic imprinting in lower vertebrates
11. Analysis finds strong match between molecular, fossil data in evolutionary studies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Evolutionary forecasting' for drug resistance
(Date:5/22/2015)... , May 22, 2015 According ... by Solution (2D, 3D, Thermal, Emotion, Forensic), by Software (Middleware, ... (Government and Utilities, Consumer and Home) - Global Forecast ... grow from $2.77 Billion in 2015 to $6.19 Billion ... Browse 79 market data Tables and   43 ...
(Date:5/19/2015)... , May 18, 2015 Fingerprint ... sensors FPC1020, FPC1025, FPC1145, FPC1155 and FPC1035 from one if ... June until and including Q3 2015 and the sensors will ... . Communicated order values for 2015 hereby amount to 740 ... Q1 2015 of 140 MSEK and a number of smaller ...
(Date:5/14/2015)... May 14, 2015  Verificient Technologies, Inc., ... and online remote proctoring, announced a new ... company and creator of the Canvas Learning ... two companies will benefit from the seamless ... As a fully integrated multifactor biometrics ...
Breaking Biology News(10 mins):Facial Recognition Market Worth $6.19 Billion by 2020 2Facial Recognition Market Worth $6.19 Billion by 2020 3Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Verificient and Instructure Announce Alliance Partnership to Provide Online Proctoring for K-12 and Higher Education Institutions 2
... Society (WCS) found that the black bears that become habituated ... behaviors exclusively from their mothers, as widely assumed. Bears that ... these habits on their own or pick them up from ... role of genetic relatedness in black bear behavior that leads ...
... AMES, Iowa -- Research led by Iowa State University limnologist, ... globe could absorb as much carbon as the world,s oceans. ... on farmland in the United States bury carbon at a ... the rate at which trees trap carbon. In addition, ponds ...
... New Version of PocketCop Software, WALL, N.J., ... BKYI), a leader in finger-based biometric,identification and wireless ... showcasing its latest mobile data solution for BlackBerry(R),smartphones ... Conference, to be held May 7-9 at the ...
Cached Biology News:When bears steal human food, mom's not to blame 2Ponds found to take up carbon like world's oceans 2BIO-key(R) Showcasing Public Safety Solutions for BlackBerry Smartphones at 2008 LEIM Conference 2BIO-key(R) Showcasing Public Safety Solutions for BlackBerry Smartphones at 2008 LEIM Conference 3
(Date:5/22/2015)... Lawrence, MA (PRWEB) May 22, 2015 ... that the U.S. Department of Agriculture (USDA), Grain ... a five year contract to Charm Sciences to ... Aflatoxin Quantitative Test (water-based) and ROSA FAST Aflatoxin ... WET-S5 Aflatoxin Quantitative Test uses Water Extraction ...
(Date:5/22/2015)... May 22, 2015 Baylor Research Institute (BRI) ... Translational Genomics Research Institute (TGen) in Phoenix, ... on accelerating early detection and treatments for patients with a ... institutions will lead to new clinical trials and access to ... the gap from bench to bedside across Baylor Scott ...
(Date:5/21/2015)... Louis, MO (PRWEB) May 21, 2015 ... assesses the safety and efficacy of pharmaceutical products and ... Drive Maryland Heights, MO 63043, a 50,000 sq. ft. ... current location, to enable strategic growth. Facility renovations will ... to the new space will occur in September. ...
(Date:5/21/2015)... 21, 2015  Susan Hedstrom, Executive Director of ... organization dedicated to supporting research to advance the ... today that FPWR has received the organization,s largest ... contributed $1 million in support of the ... "Our gift signifies our ...
Breaking Biology Technology:USDA-GIPSA (FGIS) Awards 5 Year Contract for Aflatoxin Tests to Charm Sciences 2Precision Medicine Collaboration to Increase Options for Cancer Patients 2Precision Medicine Collaboration to Increase Options for Cancer Patients 3Precision Medicine Collaboration to Increase Options for Cancer Patients 4Seventh Wave Laboratories Purchases Building for Expansion, Upcoming Move 2Seventh Wave Laboratories Purchases Building for Expansion, Upcoming Move 3The Foundation for Prader-Willi Research Receives $1M Contribution in Support of Clinical Initiatives 2
... ... Small-Scale Farmer Productivity , ... Milan, Italy (Vocus) Nov. 12, 2009 – Tackling global food security requires an ... on a local, national and international scale, DuPont Vice President and Pioneer Hi-Bred Chairman ...
... PLEASANTON, Calif., Nov. 12 Microchip Biotechnologies, Inc. (MBI), ... preparation and analysis, today announced an $18.1M close of ... commercialization of the Apollo 100 System, a sample preparation ... of the Apollo platform for the rapidly growing Next-Generation ...
... ... answers (Q&A) site that provides members the opportunity to ask and answer ... many science categories. Members can also enter a social media environment, where ... to multiple members. This environment also provides a place for members to ...
Cached Biology Technology:Start Locally, Collaborate to Increase Food Security, Says DuPont Leader to U.N. Group 2Start Locally, Collaborate to Increase Food Security, Says DuPont Leader to U.N. Group 3Start Locally, Collaborate to Increase Food Security, Says DuPont Leader to U.N. Group 4Microchip Biotechnologies Raises $18.1M in Series B Financing 2SciScout LLC Launches SciAnswers.com, a Science-Based Questions and Answers (Q&A) Site with a Social Networking Perspective. 2SciScout LLC Launches SciAnswers.com, a Science-Based Questions and Answers (Q&A) Site with a Social Networking Perspective. 3SciScout LLC Launches SciAnswers.com, a Science-Based Questions and Answers (Q&A) Site with a Social Networking Perspective. 4
... The FastPlax Titer Kit is designed for ... instead of 46 days as in other methods. ... the appearance of plaques, but the FastPlax Kit ... of AcNPV gp64 glycoprotein on the cell surface ...
...
... has been designed for recovery of DNA from TAE ... Ultra fast protocol: DNA is ready to ... easy to resuspend Bead uniformity prevents shearing of ... for PCR) DNA is eluted into sterile water ...
... is ideal for the ... (1D electrophoresis, 2D electrophoresis, ... Pharmacokinetics & Toxicology (whole ... chromatography); Physical and Material ...
Biology Products: