Navigation Links
'Evolutionary forecasting' for drug resistance
Date:9/21/2009

he upcoming study, Shamoo's team will sequence the genome of each organism both before and after the test. In addition, they'll take daily samples of the bacteria from the vessel and hold onto those for analyses. The stored samples are essentially a fossil record of the organism's adaptation to the drug. Using these, investigators can piece together the molecular path to resistance.

To determine the order the mutations occurred in, the team will use a technique created by Rice's Sarah Wu, a Will Rice College senior majoring in biochemistry and cell biology who began working in Shamoo's lab as a freshman. Using an instrument called a mass spectrometer, Wu found a way to translate the molecular changes from a particular mutation to the molecular weights of samples analyzed with the mass spectrometer.

Shamoo said the technique is important because it will allow his team to determine which mutations occurred first and to build those changes into a network-style representation that show's how an organism adapts to a specific drug.

Once the team has identified the particular mutations that convey drug resistance, they'll use X-ray crystallography to try and determine the exact molecular modifications that occur in the proteins those genes encode.

"We're interested in building those physical relationships that show how molecules confer drug resistance," Shamoo said. "The idea is that if you understand the mutation and what the mutation does to an enzyme or protein, then you can understand how that helps increase the fitness of a population of bacteria."

Shamoo said the team hopes to find a general set of rules or patterns that bacteria follow as they evolve to become drug-resistant.

For example, while the specific mutations that allow bacteria to become drug-resistant may differ from strain to strain, there may be patterns or rules that govern the order in which mutations occur and the regions of genome in which they oc
'/>"/>

Contact: Jade Boyd
jadeboyd@rice.edu
713-348-6778
Rice University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Scientists use microRNAs to track evolutionary history for first time
2. Sex in the Caribbean: Environmental change drives evolutionary change -- eventually
3. New advance in revolutionary bullet fingerprinting technique
4. Key to evolutionary fitness: Cut the calories
5. DNA template could explain evolutionary shifts
6. Newly discovered snow roots are evolutionary phenomenon
7. Biologists devise unifying framework to explain evolutionary puzzles
8. Biologists consider unifying framework to explain evolutionary puzzles
9. U of Minnesota research reveals critical role of evolutionary processes in species coexistence
10. The evolutionary foundation of genomic imprinting in lower vertebrates
11. Analysis finds strong match between molecular, fossil data in evolutionary studies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Evolutionary forecasting' for drug resistance
(Date:8/27/2014)... circuits in the brain of mice, scientists have ... research, led by Howard Hughes Medical Institute investigator ... (MIT), reveals that the connections between the part ... an experience and the part of the brain ... are malleable. , Altering those connections can ...
(Date:8/27/2014)... pathogens posing the greatest risk to Europe based upon ... of Liverpool researchers using a ,big data, approach to ... of Infection and Global Health ranked the top 100 ... animals using a system which, they believe, will help ... the spread of infectious diseases, including as a result ...
(Date:8/27/2014)... available in German . ... most common inherited disease affecting the peripheral nervous system. ... Planck Institute of Experimental Medicine and University Medical Centre ... is impaired in rats with the disease. These cells ... as myelin, which facilitates the rapid transfer of electrical ...
Breaking Biology News(10 mins):Researchers change the emotional association of memories 2Researchers change the emotional association of memories 3Researchers change the emotional association of memories 4Big data approach identifies Europe's most dangerous human and domestic animal pathogens 2Potential therapy for incurable Charcot-Marie-Tooth disease 2
... and wild--are indifferent to sweets. A new study ... their strictly carnivorous behavior. "We took a behavioral ... senior author of the study and Associate Director ... on mammalian tongues are specialized taste bud receptors ...
... invaluable decision-making tools for public health officials. As ... 2001, models can be useful in two ways: ... infection and they can allow the comparison of ... implicit assumptions that may systematically bias their predictions, ...
... of Massachusetts Amherst have discovered a tiny biological ... helps describe how microorganisms can clean up groundwater ... also have applications in the emerging field of ... extremely small dimensions. , The findings of microbiologist ...
Cached Biology News:Field of beams - Novel system uses polarized light pulses to reveal crop health 2Researchers Discover That Microbes Can Produce Miniature Electrical Wires 2Researchers Discover That Microbes Can Produce Miniature Electrical Wires 3Researchers Discover That Microbes Can Produce Miniature Electrical Wires 4
(Date:8/27/2014)... MADISON, N.J. , Aug. 27, 2014 /PRNewswire/ ... significant potential to help physicians better identify early-stage ... progression and disability, according to a new study ... from Quest Diagnostics (NYSE: DGX ) ... of the 14-3-3eta protein outperformed conventional antibody-serum testing, ...
(Date:8/27/2014)... , Aug. 27, 2014 Reportbuyer.com ... The Graphene Opportunity - A Rational View ... Graphene The New Nanotech? A similar amount ... of applications ranging from microelectronics to water treatment, ... announced the availability of the Graphene Opportunity Report, ...
(Date:8/27/2014)... Research and Markets  has announced the addition of ... Report 2014" report to their offering. ... Report 2014 is a professional and in-depth study on ... spectrometer industry. The report provides a basic ... industry chain structure. The isotope ratio mass spectrometer market ...
(Date:8/27/2014)... 27, 2014 Riviera Beach, Florida ... the creation of the Sancilio Scientific Advisory Board ... SCI’s philosophy of looking to nature for pharmaceutical ... actions are based on sound scientific data, analyses, ... Board provides a vehicle for SCI to receive ...
Breaking Biology Technology:Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 2Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 3Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 4The Graphene Opportunity - A Rational View 2The Graphene Opportunity - A Rational View 3The Graphene Opportunity - A Rational View 4Global Stable Isotope Ratio Mass Spectrometer Industry Report 2014 2New Sancilio & Company, Inc. Scientific Board 2New Sancilio & Company, Inc. Scientific Board 3
... 26, 2011 Reportlinker.com announces that ... is available in its catalogue: ... Strategies - A Guide to ... and Biopharmaceutical Industries ...
... Our understanding of what differentiates cancer cells from normal cells ... complex signal systems of individual cells. By combing two different ... research world with a tool for studying signal paths on ... published today in PLoS One . "We also ...
... In the wake of the March 11 earthquake and ... across Japan, the award-winning undergraduate internship program NanoJapan is ... rather than having U.S. undergraduates travel to Japan for ... the opportunity to send 25-30 students to Rice University ...
Cached Biology Technology:Reportlinker Adds Technology Transfer Strategies - A Guide to Maximizing Returns Within the Pharmaceutical and Biopharmaceutical Industries 2Reportlinker Adds Technology Transfer Strategies - A Guide to Maximizing Returns Within the Pharmaceutical and Biopharmaceutical Industries 3Reportlinker Adds Technology Transfer Strategies - A Guide to Maximizing Returns Within the Pharmaceutical and Biopharmaceutical Industries 4Reportlinker Adds Technology Transfer Strategies - A Guide to Maximizing Returns Within the Pharmaceutical and Biopharmaceutical Industries 5Reportlinker Adds Technology Transfer Strategies - A Guide to Maximizing Returns Within the Pharmaceutical and Biopharmaceutical Industries 6Reportlinker Adds Technology Transfer Strategies - A Guide to Maximizing Returns Within the Pharmaceutical and Biopharmaceutical Industries 7Reportlinker Adds Technology Transfer Strategies - A Guide to Maximizing Returns Within the Pharmaceutical and Biopharmaceutical Industries 8Reportlinker Adds Technology Transfer Strategies - A Guide to Maximizing Returns Within the Pharmaceutical and Biopharmaceutical Industries 9Combo method reveals cells' signal systems 2Reverse NanoJapan: Rice to host 25-30 Japanese students 2
Phosphotyrosine IgG mouse monoclonal antibody: Alkaline Phosphatase conjugate...
Rabbit polyclonal to Myosin VIIa (rating: *****) ( Abpromise for all tested applications). entrezGeneID: 4647 SwissProtID: Q13402...
Mouse monoclonal [6E10] to LAP2 ( Abpromise for all tested applications). entrezGeneID: 7112 SwissProtID: P42166...
...
Biology Products: