Navigation Links
'Evolutionary forecasting' for drug resistance
Date:9/21/2009

HOUSTON -- (Sept. 21, 2009) -- Rice University biochemists are developing a system of "evolutionary forecasting" to better understand the mechanisms of antibiotic resistance.

"Our goal is to show antibiotic makers which sets of genes a pathogen will modify to become drug-resistant," said Yousif Shamoo, the principal investigator on a new $1 million grant from the National Institute of Allergy and Infectious Diseases. "If they know the molecular path that an organism will take to become resistant to a new drug, our hope is that they can find ways to cut off that path."

Drug resistance is a major and growing problem in the U.S. Despite the best efforts of the medical community, documented cases of antibiotic-resistant pathogens like methicillin-resisistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) have increased dramatically in recent years. For example, a national study found that in 2004 more than 60 percent of patients in intensive care had MRSA and nearly 30 percent had VRE, compared with just 37 percent and 14 percent, respectively, in 1995.

Shamoo, associate professor of biochemistry and cell biology and director of Rice's Institute of Biosciences and Bioengineering, said the four-year study will follow two common pathogens, Escherichia coli and Enterococcus faecalis, as they adapt to front-line antibiotics. The researchers will identify the network of genetic adaptations that allow the pathogens to become increasingly drug-resistant.

"We'll start with a batch of bacteria in a controlled vessel, and on day one we'll add a small amount of the drug," Shamoo said. "Each day, we'll ramp up how much drug we add, and we'll do that continuously for weeks. The organism is forced to evolve or die. In previous studies using both drugs and using environmental changes like increased heat, we have found that organisms do evolve, and they do it in a repeatable, predictable way."

In t
'/>"/>

Contact: Jade Boyd
jadeboyd@rice.edu
713-348-6778
Rice University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Scientists use microRNAs to track evolutionary history for first time
2. Sex in the Caribbean: Environmental change drives evolutionary change -- eventually
3. New advance in revolutionary bullet fingerprinting technique
4. Key to evolutionary fitness: Cut the calories
5. DNA template could explain evolutionary shifts
6. Newly discovered snow roots are evolutionary phenomenon
7. Biologists devise unifying framework to explain evolutionary puzzles
8. Biologists consider unifying framework to explain evolutionary puzzles
9. U of Minnesota research reveals critical role of evolutionary processes in species coexistence
10. The evolutionary foundation of genomic imprinting in lower vertebrates
11. Analysis finds strong match between molecular, fossil data in evolutionary studies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Evolutionary forecasting' for drug resistance
(Date:9/17/2014)... scientists were instrumental in the creation of the Santa ... classify the fire threat potential of the powerful, hot, ... into an inferno. The index was introduced Sept. 17 ... and San Diego Gas and Electric. , The index ... that will be used to help fire agencies and ...
(Date:9/17/2014)... his doctoral student have designed a device based on ... fog and dew., The device could provide water in ... globe., Cheng Luo, professor in the Mechanical & Aerospace ... same College of Engineering department, published "Bioinspired Plate-Based Fog ... Chemical Society) Applied Materials & Interfaces ...
(Date:9/17/2014)... A rare genetic disorder known as Jacobsen syndrome has ... investigation by researchers at San Diego State University and ... suggesting better treatment options for people with Jacobsen syndrome, ... underpinnings of autism., Jacobsen syndrome affects approximately 1 in ... It occurs in a person when there is a ...
Breaking Biology News(10 mins):UCLA scientists play key role in developing new Santa Ana Wildfire Threat Index 2Shorebird's beak inspires UT Arlington research on water collection 2A link between Jacobsen syndrome and autism 2
... new field study confirms that an invasive weed called ... suggesting it will continue to spread across much of ... acres of grazing land almost worthless. The research, ... Research Service, was one of the most comprehensive studies ...
... What: , The 33rd CTRC-AACR San Antonio ... prevention, epidemiological, laboratory, translational and clinical breast cancer research. ... pipeline, new approaches with existing agents and emerging biology ... To help you plan your coverage of the symposium, ...
... growing potatoes, at least for growing seed potatoes. Newco ... together with Neiker-Tecnalia (the Basque Institute for Agricultural Research ... of a novel system known as aeroponics. What ... given that never before in this country the first ...
Cached Biology News:Invading weed threatens devastation to western rangelands 2Invading weed threatens devastation to western rangelands 3Newco produces seed potatoes in the open air 2Newco produces seed potatoes in the open air 3
(Date:9/18/2014)... -- MEI Pharma, Inc. (Nasdaq: MEIP ), an oncology ... cancer, announced today that Daniel P. Gold , Ph.D., ... NewsMakers in the Biotech Industry conference on Friday, September ... Broadway Hotel & Conference Center in New York ... accessed at www.meipharma.com . A replay will be available ...
(Date:9/18/2014)... 18 septembre 2014 Mapi, société créée ... 1974, a été depuis 40 ans l,un ... cliniques traditionnelles par des évaluations recentrées sur ... les impacts économiques des traitements. ... A cours d,une récente conférence téléphonique ...
(Date:9/18/2014)... SeqLL Inc., the owner of ... today the closing of a $1M Series-A funding ... Diagnostic Technologies, will increase the power of tSMS™ ... in March 2013 by Daniel Jones, a former ... BioSciences, SeqLL has continued to offer Helicos’ sequencing ...
(Date:9/18/2014)... sweeteners, promoted as aids to weight loss and diabetes ... and metabolic disease; and they do it in a ... the gut microbiota the substantial population of bacteria ... experiments in mice and humans, were published today in ... Elinav of the Weizmann Institute,s Immunology Department, who led ...
Breaking Biology Technology:MEI Pharma To Present At BioCentury's NewsMakers Conference 2MEI Pharma To Present At BioCentury's NewsMakers Conference 31974 - 2014 - Mapi fête ses 40 ans 2SeqLL Closes Series-A Funding Round for Expansion of Single Molecule Sequencing 2Gut bacteria, artificial sweeteners and glucose intolerance 2Gut bacteria, artificial sweeteners and glucose intolerance 3
... /PRNewswire-FirstCall/ - Angiotech Pharmaceuticals,Inc. (NASDAQ: ANPI , ... company, today announced that it has elected to ... trials for its Vascular Wrap,product candidate in patients ... to evaluate an imbalance of infections that have,been ...
... April 21 A group of German,investors is about to ... for a purchasing price of up to EUR 750,000. The ... will be subscribed,to by the investors. It will become effective ... Sangui account and after the capital increase will,have been entered ...
... an interview with a researcher, please contact the Communications and ... tip. For more information on ORNL and its research and ... If you have a general media-related question or comment, you ... HOMELAND SECURITY -- Protecting ports . . . ...
Cached Biology Technology:Angiotech elects to suspend Vascular Wrap(TM) pivotal clinical trials 2Angiotech elects to suspend Vascular Wrap(TM) pivotal clinical trials 3Angiotech elects to suspend Vascular Wrap(TM) pivotal clinical trials 4Investors Acquire Share in Sangui BioTech GmbH 2Story tips from the Department of Energy's Oak Ridge National Laboratory, March 2008 2Story tips from the Department of Energy's Oak Ridge National Laboratory, March 2008 3
... The MEGAscript RNAi Kit is ... large mass amounts of ready-to-use ... non-mammalian systems. The MEGAscript RNAi ... patented high-yield transcription technol-ogy and ...
UGT1A6 (D-20)...
... With its patented technology, the Lone Wolf ... any Normally Open proportional valve available on ... operation, provides repeatable high-speed performance, and ensures ... , Enhances system control and patient ...
Normal Hamster Serum...
Biology Products: