Navigation Links
Evolutionary biologist will study HIV with grant from AIDS research foundation
Date:2/25/2009

AUSTIN, TexasDr. Sara Sawyer will use a $120,000 grant from the Foundation for AIDS Research (amFAR) to study how the HIV virus and the cells it attacks have evolved together over time. The goal of her research is to discover new targets for drugs.

When HIV infiltrates cells, the virus hijacks its host's genetic machinery to produce proteins and ultimately replicate itself. It has been recently found that the retrovirus hijacks about 1,000 human genes.

"The big challenge now is to find which of these 1,000 genes and the proteins they encode are critical for HIV infection," says Sawyer, an assistant professor of molecular genetics and microbiology at The University of Texas at Austin. "Those will be good targets for blocking the virus with new antiviral drugs."

Viruses and their hosts are constantly evolving to thwart each other in an arms race that occurs over many generations and results in evolutionary change in both.

To find the genes and proteins essential for HIV to do its work in human cells, Sawyer will look in the genomes of primates for an evolutionary record of these lockstep changes.

African primates such as chimpanzees and gorillas have been evolving with the precursor to HIV, called SIV, for millions of years. They rarely get sick from the virus. Evolutionary theory predicts that the primate genes and proteins most critical to SIV infection will have evolved more rapidly over time than other genes, as the primates evolved to sidestep the viral attack.

Sawyer will look for these proteins that have changed the fastest over time. It's these proteins that will likely be the most important in blocking the retrovirus, and could point to new targets for HIV drug development.

"Mutations in host cell proteins that decrease the ability of retroviruses like HIV to multiply will be favored over time," says Sawyer. "If we can identify which of these proteins have played the most important role in ho
'/>"/>

Contact: Lee Clippard
lclippard@mail.utexas.edu
512-232-0675
University of Texas at Austin
Source:Eurekalert

Page: 1 2

Related biology news :

1. Clones on task serve greater good, evolutionary study shows
2. Adaptation to parasites drive African fishes along different evolutionary paths
3. Old developmental pathways spawn revolutionary evolutionary changes
4. New study sheds light on Galápagos hawk evolutionary history
5. A new explanation for evolutionary changes in genetic sex-determination systems
6. Predators and parasites may increase evolutionary stability
7. Time-sharing tropical birds key to evolutionary mystery
8. Evolutionary biology research on plant shows significance of maternal effects
9. Evolutionary comparison finds new human genes
10. Rebuilding the evolutionary history of HIV-1 unravels a complex loop
11. Primitive early relative of armadillos helps rewrite evolutionary family tree
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... vessel returned to Spain culminating the around the world ... picture of how the global ocean works and what ... from the atmosphere is not limited to coastal areas, ... the planet, and it is already affecting the ocean ... in CSIC Residence for Researchers in Barcelona, in a ...
(Date:9/16/2014)... salmon-rich waters of Southeast Alaska to the white sand ... lumber and tourist towns, coastal residents around the U.S. ... divide along political lines. That,s a primary finding of ... published this month in the journal Society & ... environment-related differences from place to place to place. Each ...
(Date:9/16/2014)... are responsible for practically all vital functions in ... forward signals, transport particular substances and control immune ... proteins do not function independently of each other, ... examine the protein networks, you find many similarities ... from TUM,s Chair of Plant Systems Biology. "Some ...
Breaking Biology News(10 mins):The Malaspina Expedition confirms that pollution reaches even the most remote areas of the ocean 2The Malaspina Expedition confirms that pollution reaches even the most remote areas of the ocean 3Politics divide coastal residents' views of environment, UNH research finds 2Politics divide coastal residents' views of environment, UNH research finds 3Good networkers make prime targets 2
... Every process in a cell is affected by interactions ... body and their relationship to diseases is essential to ... Ontario Genomics Institute (OGI) is providing $100,000 through its ... Toronto (U of T),s Mammalian Membrane Two-Hybrid (MaMTH) project, ...
... Institution announced today that it is a grant recipient ... the Bill & Melinda Gates Foundation. Wolf B. ... with Bing Yang from Iowa State University and Frank ... health and development research project entitled "Transformative Strategy for ...
... recovery of UK butterfly populations to extreme drought is affected by ... in the landscape. The analysis, published this week in ... butterfly collected from 79 UK Butterfly Monitoring Scheme sites between 1990 ... 1995. The study was led by Dr Tom Oliver ...
Cached Biology News:Ontario Genomics Institute invests in validation of a novel protein interaction technology at U of T 2Carnegie Institution for Science receives Grand Challenges Explorations grant 2UK butterfly populations threatened by extreme drought and landscape fragmentation 2
(Date:9/16/2014)... September 16, 2014 Convoy Therapeutics, ... and effective products to treat patients directly at ... a proprietary SPACEā„¢ Technology Platform announced today that ... will present at the White Hat Life Science ... Hyatt Regency Phoenix. In addition, interested individuals ...
(Date:9/16/2014)... 2014 /PRNewswire-iReach/ -- Researchers found that ActiveLife Scientific,s ... with bone fragility fracture when today,s standard bone ... are at risk of fracture for reasons that ... test, the DEXA bone density scan.  Study results ... and Mineral Research Annual Conference (ASBMR) in ...
(Date:9/16/2014)... In preparation for VARTECH 2014, 2FA, Inc., ... focused on authentication and SSO announced today that their ... generate a OTP through the presentation of an RFID ... RFID authentication, 2FA,s solutions have leveraged the existence of ... RFID authentication is broadly deployed in healthcare and other ...
(Date:9/16/2014)... (PRWEB) September 16, 2014 According to ... Toronto affiliate of ITRA Global, new development in Downtown ... Toronto city council approving another 755 storeys of new ... appears construction cranes will be dominating the Toronto skyline ... to have an unquenchable thirst for new development. , ...
Breaking Biology Technology:Convoy Therapeutics to Present at WhiteHat Investor Conference September 18, 2014 2Convoy Therapeutics to Present at WhiteHat Investor Conference September 18, 2014 3ActiveLife's BMSi Test Provides Hope for 160 Million with Undetectable Risk of Bone Fracture 2ActiveLife's BMSi Test Provides Hope for 160 Million with Undetectable Risk of Bone Fracture 32FA, Inc. Announces RFID-based One-Time Password (OTP) Authentication 2ITRA Global Reports Downtown Toronto Real Estate Development is in High Gear 2ITRA Global Reports Downtown Toronto Real Estate Development is in High Gear 3
... NeoGenomics, Inc. (OTC Bulletin Board: NGNM) today announced ... Equity Conference at 12:30 PM EDT on ... Hotel in Hollywood, FL.  Robert Gasparini, the Company,s ... NeoGenomics, market positioning, financial performance, and strategic direction and then ...
... /PRNewswire-Asia-FirstCall/ -- China-Biotics, Inc.,("China-Biotics", the "Company") (Nasdaq: CHBT ), the leading ... management will present at the Bank of America Merrill Lynch Health,Corporate Day. The ... Merrill,Lynch Client Service Center in Hong Kong . , ... About China-Biotics , ...
... ... The iuvo™ Chemotaxis Assay ... technology to provide quantitative measurements of neutrophil chemotaxis ( ... remains stable over the time period of the assay. ...
Cached Biology Technology:NeoGenomics to Present at Noble Financial's 6th Annual Equity Conference on Monday, June 7th 2NeoGenomics to Present at Noble Financial's 6th Annual Equity Conference on Monday, June 7th 3China-Biotics to Present at Bank of America Merrill Lynch Healthcare Event on June 22 2BellBrook Labs Launches Groundbreaking New Microplate for High Content Chemotaxis Assays in a Stable Gradient 2BellBrook Labs Launches Groundbreaking New Microplate for High Content Chemotaxis Assays in a Stable Gradient 3BellBrook Labs Launches Groundbreaking New Microplate for High Content Chemotaxis Assays in a Stable Gradient 4
... Human Pathogenic Viruses The ... (NCPV) preserves well characterised, authenticated ... secure facility, and NCPV is ... or nucleic acids derived from ...
... and easy to use Ascent ... all members of the Ascent ... a clear and easy-to-follow approach ... user-friendly and highly sophisticated data ...
Roll of Mesh 5m x 25cm...
... The Beacon 2000 Fluorescence Polarization ... basic research and assay development. Standard ... Beacon 2000 System uses a quartz-halogen ... range of 360-700 nm. It accommodates ...
Biology Products: