"Darwin simply didn't have access to the information we have," explains Parker. "If Darwin had been aware of the species that have an appendix attached to a large cecum, and if he had known about the widespread nature of the appendix, he probably would not have thought of the appendix as a vestige of evolution."
He also was not aware that appendicitis, or inflammation of the appendix, is not due to a faulty appendix, but rather due to cultural changes associated with industrialized society and improved sanitation. "Those changes left our immune systems with too little work and too much time their hands a recipe for trouble," says Parker.
That notion wasn't proposed until the early 1900's, and "we didn't really have a good understanding of that principle until the mid 1980's," Parker said. "Even more importantly, Darwin had no way of knowing that the function of the appendix could be rendered obsolete by cultural changes that included widespread use of sewer systems and clean drinking water."
Parker says now that we understand the normal function of the appendix, a critical question to ask is whether we can do anything to prevent appendicitis. He thinks the answer may lie in devising ways to challenge our immune systems today in much the same manner that they were challenged back in the Stone Age. "If modern medicine could figure out a way to do that, we would see far fewer cases of allergies, autoimmune disease, and a
|Contact: Michelle Gailiun|
Duke University Medical Center