Navigation Links
Evolution of equine influenza led to canine offshoot which could mix with human influenza
Date:6/19/2014

Equine influenza viruses from the early 2000s can easily infect the respiratory tracts of dogs, while those from the 1960s are only barely able to, according to research published ahead of print in the Journal of Virology. The research also suggests that canine and human influenza viruses can mix, and generate new influenza viruses.

Canine influenza is a relatively new disease. The first appearance is believed to be in 2003, as a result of direct transfer of a single equine influenza virus to dogs in a large greyhound training facility and was subsequently carried to many states by the infected greyhound, say the researchers. Similar transfers have occurred among foxhounds in the UK, and in dogs kept near infected horses during a 2007 outbreak in Australia, they report.

In the study, investigators from the United States and the United Kingdom infected dog tracheal explant culturesessentially pieces of trachea cultured in the laboratory to mimic the cellular complexity and the host physiology of the hostwith canine influenza virus, equine influenza virus, and human influenza viruses. (The use of explants has increased in recent years, and they have been shown to be useful for studies of viral pathogenesis.) They then compared the growth of the viruses, and the damage they wrought.

Infection of equine influenza virus from 2003 caused an infection much like that from canine influenza virus in terms of the virus' rate of replication and the extensive tissue damage it caused. In contrast, viruses from 1963 replicated poorly, and caused relatively minor lesions in comparison with the 2003 virus.

The investigators also transfected cells with DNA containing the genes of both canine and human influenza viruses, to determine whether the genes from the two viruses were compatible with each other.

"We showed that the genes are indeed compatible, and we also showed that chimeric viruses carrying human and canine influenza genes can infect the dog tracheas," says corresponding author Pablo Murcia of the University of Glasgow Centre for Virus Research, UK.

That, he says, means that such chimeric viruses might occur naturally, and would likely be able to infect dogs. These findings have significant implications because they show that dogs might act as "mixing vessels" in which novel viruses with pandemic potential could emerge.

Studies investigating whether they could infect human lungs are underway.


'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Related biology news :

1. Evolution depends on rare chance events, molecular time travel experiments show
2. High-altitude weight loss may have an evolutionary advantage
3. The transmission of information via proteins could revolutionize drug discovery
4. Eye evolution: A snapshot in time
5. What can plants reveal about gene flow? That its an important evolutionary force
6. Researchers map the epic evolution of a ring species
7. Rapid evolution aids spread of exotic plant species
8. Delegating the dirty work is a key to evolution
9. Caught in the act: Study probes evolution of California insect
10. Study uncovers new evidence on species evolution
11. Primates and patience -- the evolutionary roots of self control
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... patient care by providing unparalleled technology to leaders of the medical imaging industry.  As ... added to the range of products distributed by Ampronix. Photo - ... ... ... ...
(Date:5/16/2016)... 16, 2016   EyeLock LLC , a market ... opening of an IoT Center of Excellence in ... the development of embedded iris biometric applications. ... convenience and security with unmatched biometric accuracy, making it ... from DNA. EyeLock,s platform uses video technology to deliver ...
(Date:5/9/2016)... May 9, 2016 Elevay is ... to expanding freedom for high net worth professionals seeking ... today,s globally connected world, there is still no substitute ... ever duplicate sealing your deal with a firm handshake. ... by taking advantage of citizenship via investment programs like ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... 24, 2016 , ... While the majority of commercial spectrophotometers and fluorometers use ... 6000i models are higher end machines that use the more unconventional z-dimension of 20mm. ... from the bottom of the cuvette holder. , FireflySci has developed several Agilent ...
(Date:6/23/2016)... , June 23, 2016 /PRNewswire/ - FACIT ... Ontario biotechnology company, Propellon Therapeutics ... development and commercialization of a portfolio of first-in-class ... Epigenetic targets such as WDR5 represent an exciting ... significantly in precision medicine for cancer patients. Substantial ...
(Date:6/23/2016)... NEW YORK , June, 23, 2016  The ... students to envision new ways to harness living systems ... of Modern Art (MoMA) in New York ... more than 130 participating students, showcased projects at MoMA,s ... included Paola Antonelli , MoMA,s senior curator of ...
(Date:6/23/2016)... Ky. , June 23, 2016 ... two Phase 1 clinical trials of its complement ... placebo-controlled, single and multiple ascending dose studies designed ... pharmacodynamics (PD) of subcutaneous injection in healthy adult ... subcutaneously (SC) either as a single dose (ranging ...
Breaking Biology Technology: