Navigation Links
Evolution of equine influenza led to canine offshoot which could mix with human influenza

Equine influenza viruses from the early 2000s can easily infect the respiratory tracts of dogs, while those from the 1960s are only barely able to, according to research published ahead of print in the Journal of Virology. The research also suggests that canine and human influenza viruses can mix, and generate new influenza viruses.

Canine influenza is a relatively new disease. The first appearance is believed to be in 2003, as a result of direct transfer of a single equine influenza virus to dogs in a large greyhound training facility and was subsequently carried to many states by the infected greyhound, say the researchers. Similar transfers have occurred among foxhounds in the UK, and in dogs kept near infected horses during a 2007 outbreak in Australia, they report.

In the study, investigators from the United States and the United Kingdom infected dog tracheal explant culturesessentially pieces of trachea cultured in the laboratory to mimic the cellular complexity and the host physiology of the hostwith canine influenza virus, equine influenza virus, and human influenza viruses. (The use of explants has increased in recent years, and they have been shown to be useful for studies of viral pathogenesis.) They then compared the growth of the viruses, and the damage they wrought.

Infection of equine influenza virus from 2003 caused an infection much like that from canine influenza virus in terms of the virus' rate of replication and the extensive tissue damage it caused. In contrast, viruses from 1963 replicated poorly, and caused relatively minor lesions in comparison with the 2003 virus.

The investigators also transfected cells with DNA containing the genes of both canine and human influenza viruses, to determine whether the genes from the two viruses were compatible with each other.

"We showed that the genes are indeed compatible, and we also showed that chimeric viruses carrying human and canine influenza genes can infect the dog tracheas," says corresponding author Pablo Murcia of the University of Glasgow Centre for Virus Research, UK.

That, he says, means that such chimeric viruses might occur naturally, and would likely be able to infect dogs. These findings have significant implications because they show that dogs might act as "mixing vessels" in which novel viruses with pandemic potential could emerge.

Studies investigating whether they could infect human lungs are underway.


Contact: Jim Sliwa
American Society for Microbiology

Related biology news :

1. Evolution depends on rare chance events, molecular time travel experiments show
2. High-altitude weight loss may have an evolutionary advantage
3. The transmission of information via proteins could revolutionize drug discovery
4. Eye evolution: A snapshot in time
5. What can plants reveal about gene flow? That its an important evolutionary force
6. Researchers map the epic evolution of a ring species
7. Rapid evolution aids spread of exotic plant species
8. Delegating the dirty work is a key to evolution
9. Caught in the act: Study probes evolution of California insect
10. Study uncovers new evidence on species evolution
11. Primates and patience -- the evolutionary roots of self control
Post Your Comments:
(Date:4/15/2016)... , April 15, 2016  A new partnership ... more accurate underwriting decisions in a fraction of ... competitively priced and high-value life insurance policies to ... With Force Diagnostics, rapid testing (A1C, ... data readings (blood pressure, weight, pulse, BMI, and ...
(Date:3/31/2016)... 2016   LegacyXChange, ... "Company") LegacyXChange is excited to release its ... to be launched online site for trading 100% guaranteed ... will also provide potential shareholders a sense of the ... an industry that is notorious for fraud. The video ...
(Date:3/22/2016)... 2016 According to ... for Consumer Industry by Type (Image, Motion, Pressure, ... & IT, Entertainment, Home Appliances, & Wearable ... 2022", published by MarketsandMarkets, the market for ... USD 26.76 Billion by 2022, at a ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... -- Liquid Biotech USA , Inc. ... Research Agreement with The University of Pennsylvania ("PENN") ... patients.  The funding will be used to assess ... outcomes in cancer patients undergoing a variety of ... to support the design of a therapeutic, decision-making ...
(Date:6/24/2016)... ... , ... While the majority of commercial spectrophotometers and fluorometers use the z-dimension ... are higher end machines that use the more unconventional z-dimension of 20mm. Z-dimension ... bottom of the cuvette holder. , FireflySci has developed several Agilent flow cell ...
(Date:6/23/2016)... Mass. , June 23, 2016   ... development of novel compounds designed to target cancer ... napabucasin, has been granted Orphan Drug Designation from ... the treatment of gastric cancer, including gastroesophageal junction ... stemness inhibitor designed to inhibit cancer stemness pathways ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... YM (Yeast and Mold) microbial test has received AOAC Research Institute approval 061601. ... microbial tests introduced last year,” stated Bob Salter, Vice President of Regulatory and ...
Breaking Biology Technology: