Navigation Links
Evolution of diverse sex-determining mechanisms in mammals
Date:7/29/2013

d other ways to play nature's mating game.

The CWRU team attributed the rapid evolvability of sex determination in rodents to a novel protein domain added to the SRY protein. Scientists knew that this domain existed, but Weiss and his team wanted to understand more about its function in gene regulation and its role in evolution. The team determined that the new protein domain acts as a "genetic capacitor," providing a protective buffer to the Sry gene. This buffer allowed male development even when a mutation occurs elsewhere in the gene that might otherwise cause sex reversalbut the buffer is unstable over generations. Slippage of DNA during the production of sperm can lead to sudden changes in the length of the buffer and the degree of protection. By analogy to a capacitor in an electric circuit, the team suggested that this domain can "discharge" to accelerate the pace of evolutionary change. The idea of a genetic capacitor was pioneered by MIT Professor Susan Lindquist in studies of heat-shock proteins in fruit flies in (Nature, "Hsp90 as a capacitor for morphological evolution") and the present paper extended this idea to the pace of mammalian evolution.

How did the Sry buffer arise? "We discovered that a genetic accident 20 million years ago in an ancestral rodent holds the key to solving this puzzle. A simple DNA repeat sequence (called a 'micro-satellite') invaded the Y chromosome and was incorporated into the Sry gene. This invasion accelerated the evolvability of Sry and probably the Y chromosome in general, enabling this subgroup of rodents to explore new molecular mechanisms of sex determination," Weiss said.

Weiss and his team will continue this research, but believe these initial results may have additional implications for our understanding of human evolution and genetics. Because rodents have higher mutation rates and shorter life spans, they also evolve more rapidly and so provide a natural laboratory for studies of m
'/>"/>

Contact: Amanda Petrak
amanda.petrak@case.edu
216-368-0345
Case Western Reserve University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Leading evolutionary scientist to discuss how genome of bacteria has evolved
2. An evolutionary surprise
3. Ancient Egyptian cotton unveils secrets of domesticated crop evolution
4. Did climate change shape human evolution?
5. A University of Tennessee professors hypothesis may be game changer for evolutionary theory
6. Analysis of stickleback genome sequence catches evolution in action
7. Study shows unified process of evolution in bacteria and sexual eukaryotes
8. Rapid method of assembling new gene-editing tool could revolutionize genetic research
9. Whats in a surname? New study explores what the evolution of names reveals about China
10. Scientists trace evolutionary history of what mammals eat
11. Not by DNA alone: How the epigenetics revolution is fostering new medicines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2014)... (SACRAMENTO, Calif.) Mothers of children with autism are significantly ... during their pregnancies than the mothers of children who ... UC Davis MIND Institute has found. , Low iron ... autism in the child if the mother was 35 ... or if she suffered from metabolic conditions such as ...
(Date:9/21/2014)... In recent years, new strains of bacteria have emerged ... these superbugs, including drug-resistant forms of tuberculosis and staphylococcus, ... at least 23,000. Despite the urgent need for new ... antibiotics in the past decade. , MIT engineers have ... Using a gene-editing system that can disable any target ...
(Date:9/19/2014)... Call it the Jimmy Durante of dinosaurs ... nasal profile. The new dinosaur, named Rhinorex ... University and Brigham Young University, lived in what ... during the Late Cretaceous period. , Rhinorex, which ... and a close relative of other Cretaceous hadrosaurs ...
Breaking Biology News(10 mins):Mothers of children with autism less likely to have taken iron supplements 2Battling superbugs 2Battling superbugs 3Battling superbugs 4New hadrosaur noses into spotlight 2
... to the evolutionary puzzle to explain why certain mammal families ... In research published in Proceedings of the Royal Society ... Dr Alistair Evans proposed a new theory explaining the diversity ... around two grams, to the blue whale which clocks in ...
... June 24, 2013 /PRNewswire-iReach/ -- Strax Rejuvenation, one of the ... just announced a "Get Ready for Summer" promotion that features ... (Photo: http://photos.prnewswire.com/prnh/20130624/CG36984 ) For ... syringe instead of the usual price of $550; and Radiesse ...
... from a rare metabolic complication during pregnancy are programmed to ... Journal of Clinical Investigation . The study is ... babies born to mothers with intrahepatic cholestasis of pregnancy (ICP), ... by the build-up of bile acids in the bloodstream. ...
Cached Biology News:From minute to massive -- mammal size evolution explained 2Non-Surgical Procedures are Now Available at a Discount at Strax Rejuvenation 2Non-Surgical Procedures are Now Available at a Discount at Strax Rejuvenation 3Rare pregnancy condition programs babies to become overweight in later life 2Rare pregnancy condition programs babies to become overweight in later life 3
(Date:9/22/2014)... 22, 2014 Pearl's Premium Ultra Low ... drought tolerant grass seed this week with the release ... announcement coincides with the fact that it is time ... many believe. , As of the date 6/4/13, ... reviews by industry experts and the media including: ...
(Date:9/22/2014)... tiny cell fragments whose job it is to stop ... nucleus. But they can "feel" the physical environment around ... , Platelets respond to surfaces with greater stiffness by ... on" other platelets and other components of the clotting ... we give them credit for, in that they are ...
(Date:9/22/2014)... create a highly sensitive chemical sensor based on the ... electronic properties that the researchers were able to exploit ... times. , The study is available online in advance ... Salehi- Khojin, asst professor of mechanical and industrial engineering ... Bijandra Kumar, post doc where they are doing research ...
(Date:9/22/2014)... Topical BioMedics, Inc., is celebrating 20 ... their suffering, restoring hope an quality of life and ... possible because of the innovative cellular biomedicines research that ... reality. , The company was founded in 1994 ... (president, chief of research, and Topricin inventor), Aurora Paradise ...
Breaking Biology Technology:Pearl's Premium Ultra Low Maintenance Lawn Seed Announces A Major Breakthrough In Drought Tolerant Grass Seed 2Platelets modulate clotting behavior by 'feeling' their surroundings 2Graphene imperfections key to creating hypersensitive 'electronic nose' 2Topical BioMedics (Topricin) Celebrates 20 Years of Providing Hope and Quality of Life...As Topricin Is Declared “The 21st Century Standard of Care for Pain Management” 2Topical BioMedics (Topricin) Celebrates 20 Years of Providing Hope and Quality of Life...As Topricin Is Declared “The 21st Century Standard of Care for Pain Management” 3Topical BioMedics (Topricin) Celebrates 20 Years of Providing Hope and Quality of Life...As Topricin Is Declared “The 21st Century Standard of Care for Pain Management” 4Topical BioMedics (Topricin) Celebrates 20 Years of Providing Hope and Quality of Life...As Topricin Is Declared “The 21st Century Standard of Care for Pain Management” 5Topical BioMedics (Topricin) Celebrates 20 Years of Providing Hope and Quality of Life...As Topricin Is Declared “The 21st Century Standard of Care for Pain Management” 6
... insiders knowingly misrepresented the ... company ... Shapiro filed a,proposed class-action lawsuit on behalf of CellCyte Genetics ... company and chief executive officer Gary A.,Reys, background, causing company ...
... Jan. 18 Brinks Hofer Gilson & Lione, one ... States, is,pleased to announce that 21 of its attorneys ... survey conducted by Law & Politics magazine.,Additionally, 11 Brinks ... Martin Addy, chair of the Appellate Group at Brinks, ...
... Record 20 Million Signatures Collected on myLifetime.com in ... Bipartisan Breast Cancer Patient Protection Act Allows Women Choice to, Recuperate ... ... Cancer Surgery -, NEW YORK, Jan. 18 "Desperate ...
Cached Biology Technology:Hagens Berman Sobol Shapiro: Lawsuit Filed Against CellCyte Genetics Corporation 2Hagens Berman Sobol Shapiro: Lawsuit Filed Against CellCyte Genetics Corporation 3Twenty-One Brinks Hofer Gilson & Lione Attorneys Named 2008 'Illinois Super Lawyers' 2Emmy(R)- and Golden Globe(R)-Nominated Actress Marcia Cross to Join Lifetime Networks and Members of Congress From Both Parties at Capitol Hill Press Conference 2Emmy(R)- and Golden Globe(R)-Nominated Actress Marcia Cross to Join Lifetime Networks and Members of Congress From Both Parties at Capitol Hill Press Conference 3
Request Info...
Human acetylcholine receptor (AChR)-alpha. Exhibits homogenous, high affinity,binding to the receptor. Binds weakly to a64-78. Inhibits binding of many,myasthenia gravis sera to human AChR....
...
Hybridization Buffer 3.6 ml...
Biology Products: