Navigation Links
Evolution of diverse sex-determining mechanisms in mammals
Date:7/29/2013

Scientists historically have argued that evolution proceeds through gradual development of traits. But how can incremental changes apply to the binary switch between two sexes, male or female? Researchers at Case Western Reserve University's School of Medicine have found that a genetic process among the many species of rodents could have significant implications regarding our assumptions about sex determination and the pace of evolution.

"What we addressed is a long-standing puzzle in natural history: why different types of rodents can exhibit profound differences in how male sex is determined in the embryo," said Michael Weiss, MD, PhD, chairman of the Department of Biochemistry, the Cowan-Blum Professor of Cancer Research and a professor of biochemistry and medicine. "Some rodent populations have both XY males and XY females, and in other populations the Y chromosome has disappeared entirely."

In a study published in Proceedings of the National Academy of Sciences, Weiss and his research team analyzed the Sry gene, which is part of the Y chromosome. This mammalian gene, which steers differentiation in the embryonic gonad toward the development of testes, begins the process leading to the birth of males. For most mammals, including primates, Sry is a conserved feature of the Y chromosome, ultimately giving rise to male anatomy; females generally have two X chromosomes and no Y.

But within anomalous families of rodents, common in South America, activation of the Sry gene may have uncertain consequences. Some of these groups have both XY males and XY females as normal components of the population. Other related species have even lost their Y chromosomes altogether. Without the emergence of compensating ways of specifying sex, the species could not produce malesand would become extinct. For such rodents, therefore, evolution meant inventing entirely different methods of sex determination. These mammals have in essence evolve
'/>"/>

Contact: Amanda Petrak
amanda.petrak@case.edu
216-368-0345
Case Western Reserve University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Leading evolutionary scientist to discuss how genome of bacteria has evolved
2. An evolutionary surprise
3. Ancient Egyptian cotton unveils secrets of domesticated crop evolution
4. Did climate change shape human evolution?
5. A University of Tennessee professors hypothesis may be game changer for evolutionary theory
6. Analysis of stickleback genome sequence catches evolution in action
7. Study shows unified process of evolution in bacteria and sexual eukaryotes
8. Rapid method of assembling new gene-editing tool could revolutionize genetic research
9. Whats in a surname? New study explores what the evolution of names reveals about China
10. Scientists trace evolutionary history of what mammals eat
11. Not by DNA alone: How the epigenetics revolution is fostering new medicines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... Dec. 16, 2014 Research and Markets ... of the "Global Chemical Sensor Market 2015-2019" ... http://photos.prnewswire.com/prnh/20130307/600769 One major ... demand for medical sensors in biomedical applications. Chemical ... quick and correct diagnosis during surgical procedures. The ...
(Date:12/11/2014)... WINSTON SALEM, N.C. , Dec. 10, 2014  That ... known for quite a while. Hypertension – the medical term ... disease in the early 1800s, and the inflatable cuff that,s ... That doesn,t, however, mean there,s nothing new about hypertension, ... punctured some long-held beliefs about the condition and the best ...
(Date:12/10/2014)... 2014 CIE San Diego has launched an ... connective tissue that enhances care coordination among social service ... client-level information; earned a second $1 million grant from ... seniors aging in community and; will be recognized as ... th 4-6p. CIE San Diego today ...
Breaking Biology News(10 mins):Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4
... MADISON Denizens of oceans, lakes and even ... in intricately patterned, glass-like shells. Curiously, these tiny phytoplankton ... chips., Diatoms build their hard cell walls by laying ... the key material of the semiconductor industrysilicon. If we ...
... of Exeter has highlighted the problems of reintroducing ... online in the journal Biological Conservation, the research ... that are released into their natural habitats. On ... in the wild, with most deaths related to ...
... This release is available in French and ... Scherrer Institute (PSI) and the EPFL in Switzerland have ... at wavelengths used in typical medical and industrial imaging ... x-ray radiographs and could be used to diagnose the ...
Cached Biology News:In diatom, scientists find genes that may level engineering hurdle 2Captive carnivores not up to wild living 2New technology sharpens X-ray vision 2
(Date:12/17/2014)... , Dec. 17, 2014 CASI Pharmaceuticals, Inc. ... to the acquisition, development and commercialization of innovative therapeutics ... global market with a primary commercial focus on ... been granted a Type C meeting with the U.S. ... will be held in February 2015.  During this meeting ...
(Date:12/15/2014)... 15, 2014 METTLER TOLEDO is ... tool, ParticleView V19 with PVM technology , ... particle vision and measurement tool continuously captures high-resolution ... ParticleView V19 then automatically prepares a report pairing ... size and concentration changes. This compelling blend of ...
(Date:12/15/2014)... 15, 2014  GlassesOff Inc. (OTCBB: GLSO) announced today ... an independent director of the Company,s Board of Directors. ... served as its CEO until its acquisition by ... million transaction. Recognized as the inventor of the first ... provided Wi-Fi -based RFID solutions focused on improving operational ...
(Date:12/13/2014)... CanDiag, Inc., a University of North Carolina ... name to OncoTab, Inc. , “The new name ... today,” said CEO and Chief Science Officer, Dr. Pinku ... cancer diagnostics to include imaging and therapies, and our ... Founded in 2011 by Dr. Mukherjee, an Irwin Belk ...
Breaking Biology Technology:CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 2CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 3CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 4CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 5New Real-Time In Situ Probe-Based Video Microscope from METTLER TOLEDO 2AeroScout Founder Joins GlassesOff's Board of Directors 2AeroScout Founder Joins GlassesOff's Board of Directors 3CanDiag Inc. Expands Product Scope Under a New Name: OncoTab, Inc. 2
... Customer Potential Management , a developer of databases ... relationship management solution has been implemented at the Michigan ... used the CRM solution to promote its collaboration with ... partnership with oncologists from both hospitals. While market research ...
... last week that he is planning to have a ... will provide access to his electronic medical records. ... Foundation announced that it has licensed California research firm ... On another note, Madison biotech firm Platypus Technologies ...
... care sector venture capital shows Wisconsin near the bottom for investments ... up as the state's investment funds begin a new cycle. ... formation and management counseling service specializing in the health care sector. ... is we felt like a lot of the deals that were ...
Cached Biology Technology:Wisconsin ranks low in mid-year health care capital investment report 2Wisconsin ranks low in mid-year health care capital investment report 3