Navigation Links
Evolution of complexity recreated using 'molecular time travel'
Date:1/8/2012

Much of what living cells do is carried out by "molecular machines" physical complexes of specialized proteins working together to carry out some biological function. How the minute steps of evolution produced these constructions has long puzzled scientists, and provided a favorite target for creationists.

In a study published early online on Sunday, January 8, in Nature, a team of scientists from the University of Chicago and the University of Oregon demonstrate how just a few small, high-probability mutations increased the complexity of a molecular machine more than 800 million years ago. By biochemically resurrecting ancient genes and testing their functions in modern organisms, the researchers showed that a new component was incorporated into the machine due to selective losses of function rather than the sudden appearance of new capabilities.

"Our strategy was to use 'molecular time travel' to reconstruct and experimentally characterize all the proteins in this molecular machine just before and after it increased in complexity," said the study's senior author Joe Thornton, PhD, professor of human genetics and evolution & ecology at the University of Chicago, professor of biology at the University of Oregon, and an Early Career Scientist of the Howard Hughes Medical Institute.

"By reconstructing the machine's components as they existed in the deep past," Thornton said, "we were able to establish exactly how each protein's function changed over time and identify the specific genetic mutations that caused the machine to become more elaborate."

The study a collaboration of Thornton's molecular evolution laboratory with the biochemistry research group of the UO's Tom Stevens, professor of chemistry and member of the Institute of Molecular Biology focused on a molecular complex called the V-ATPase proton pump, which helps maintain the proper acidity of compartments within the cell.

One of the pump's major
'/>"/>

Contact: John Easton
john.easton@uchospitals.edu
773-795-5225
University of Chicago Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Over 65 million years North American mammal evolution has tracked with climate change
2. Head-first diversity shown to drive vertebrate evolution
3. Human skull study causes evolutionary headache
4. Evolution at warp speed: Hatcheries change salmon genetics after a single generation
5. A small step for lungfish, a big step for the evolution of walking
6. New disinfection technique could revolutionize hospital room cleaning
7. Survival of the fittest: Linguistic evolution in practice
8. Journal of Neuroscience: Why evolutionarily ancient brain areas are important
9. Studying bat skulls, evolutionary biologists discover how species evolve
10. Predators drive the evolution of poison dart frogs skin patterns
11. Study of flower petals shows evolution at the cellular level
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... A study published online in the International ... novel approach to preventing cervical cancer based on findings ... after removal of a discrete population of cells in ... study that looked at squamocolumnar junction cells, or SCJ ... have been implicated as the origins of cervical cancer. ...
(Date:7/25/2014)... consume the healthcare community and remain priority ... To address the worldwide crisis of obesity ... global leaders in diabetes, epidemiology and public ... and development of diverse intervention programs in ... This book on "Global Health Perspectives in ...
(Date:7/25/2014)... complex congenital central nervous system disease that is ... tubes during the embryonic phase. Many patients have ... and neurocognitive retardation. Such problems decrease the patients, ... at Ankara Physical Medicine and Rehabilitation Education and ... children with SB, using the Pediatric Evaluation of ...
Breaking Biology News(10 mins):Clearing cells to prevent cervical cancer 2What constitutes an effective response to the global 'diabesity' tsunami? 2
... LAFAYETTE, Ind. - Just months after the soybean genome ... long-sought gene that controls the plant,s main stem growth ... of soybean plants that will allow producers to incorporate ... (Jen-Shin Ma), an assistant professor of agronomy, used the ...
... -- The National Academy of Sciences today announced the ... from 14 countries in recognition of their distinguished and ... held this morning during the business session of the ... today bring the total number of active members to ...
... , April 27 The "Great Reflation Experiment" ... the economy following the recent recession -- has been successful ... says Max Bublitz , chief strategist and portfolio manager ... of Virtus Investment Partners (Nasdaq: VRTS ), ...
Cached Biology News:Gene discovery may lead to new varieties of soybean plants 272 new members chosen by Academy 272 new members chosen by Academy 372 new members chosen by Academy 472 new members chosen by Academy 572 new members chosen by Academy 672 new members chosen by Academy 772 new members chosen by Academy 8Economic Headwinds a 'Very Big Deal' to Virtus Strategist 2Economic Headwinds a 'Very Big Deal' to Virtus Strategist 3Economic Headwinds a 'Very Big Deal' to Virtus Strategist 4
(Date:7/25/2014)... July 25, 2014 /PRNewswire-iReach/ -- Xybion Corporation, the ... global corporations operating in highly regulated industries, announced ... annual Global User Group Conference, Xybion International Exchange, ... Philadelphia, Pennsylvania at the Sheraton Society ... This year,s conference theme ...
(Date:7/24/2014)... novel combination of microscopy and data processing has given ... Laboratory an unprecedented look at the surface of a ... , The research team led by ORNL,s Zheng ... perovskite manganite, a complex material that exhibits dramatic magnetic ... behavior could benefit researchers who are interested in using ...
(Date:7/24/2014)...  ECC West Africa, LLC (ECC) signed a contract ... College Hospital (UCH) Ibadan Board of Management for the ... construct, and operate and maintain a new, state-of-the-art Cancer ... the first of the 4-phase project, ECC will conduct ... UCH Ibadan intends to finance and develop the Cancer ...
(Date:7/24/2014)... at the University of Delaware, is known worldwide ... engineering, environmental sustainability and electronics. , His early ... a well-defined, crystalline structure. At the atomic scale, ... zeolites can separate molecules with size differences of ... a nanometer), making them useful to the chemical ...
Breaking Biology Technology:Xybion Announces It Will Host International User Conference in Philadelphia 2Xybion Announces It Will Host International User Conference in Philadelphia 3ORNL study reveals new characteristics of complex oxide surfaces 2ECC Signs a Contract for the Finance, Design, and Construction of a Premier Cancer Institute in Ibadan, Nigeria 2University of Delaware researcher describes new approach for creating organic zeolites 2
... III schizophrenia study, -- In total, nine sales contracts signed since 1 ... ... -- $3 million in revenue already locked in for FY 2009, ... a contract with an international,pharmaceutical company to provide its computerized cognitive testing,technology and associated ...
... YORK, Aug. 11 Bion Environmental,Technologies, Inc. (OTC ... that its U.S. Patent application 11/106,751 entitled "Low ... patent,application was made on April 15, 2005; upon ... and will remain in force until December,26, 2021., ...
... TELK ) reported a net loss of $13.6 million, or ... compared with a net loss of,$14.3 million, or $0.27 per ... loss for the second quarter ended June 30, 2008, includes,a ... reflected in interest and other income (expense)., For the ...
Cached Biology Technology:Sales Contracts Worth $2.3 Million Signed Since 1 July 2008 2Bion Announces Approval of New U.S. Patent for Phosphorus Removal Process for Livestock Waste Environmental Treatment 2Bion Announces Approval of New U.S. Patent for Phosphorus Removal Process for Livestock Waste Environmental Treatment 3Bion Announces Approval of New U.S. Patent for Phosphorus Removal Process for Livestock Waste Environmental Treatment 4Telik Announces Financial Results For 2008 Second Quarter 2Telik Announces Financial Results For 2008 Second Quarter 3Telik Announces Financial Results For 2008 Second Quarter 4
Request Info...
1+ mg expected yield of purified protein, expressed in insect cells - excludes cDNA...
... bioinformatics software that has changed the way ... design of BioNumerics allows for integration and ... data employed for the characterization of organisms ... protein gels, HPLC, VNTR, MLST, SNP, fatty ...
Request Info...
Biology Products: