In addition to providing fundamental insights into the early evolution of the estrogen receptor, research by a team at the University of California, San Diego School of Medicine may lead to a contraceptive for female lampreys a jawless fish considered an invasive pest species in the Great Lakes region of the United States. This could prove important to the Great Lakes region, where lampreys aggressively consume trout, salmon, sturgeon and other game fish.
"Since the introduction of sea lamprey to the Great Lakes, the fisheries have been devastated, and as a result, there is much interest in finding new methods to control the lamprey population," said Michael E. Baker, PhD, professor in UC San Diego's Department of Medicine, Division of Nephrology-Hypertension. "Our research could lead to a contraceptive for female lamprey, providing a method to control their reproduction in the Great Lakes." The researchers' findings will be published by PloS ONE on June 25.
Lampreys evolved about 450 million years ago, before the appearance of sharks. In contrast to sharks, fish and land vertebrates, lampreys have no jaw. They feed on fish by attaching themselves to the fish and sucking their body fluids. Their aggressive consumption of game fish has eliminated many natural predators of the alewife, another invasive species on the Great Lakes. This has allowed the alewife population to explode, with adverse effects on many native fish species.
As part of a program to understand the evolution of steroid hormone signaling, the UC San Diego researchers characterized the estrogen-binding site on the estrogen receptor in the sea lamprey. To accomplish this, Baker along with David Chang, student in the UC San Diego Department of Biology, and Charlie Chandsawangbhuwana, graduate student of Bioengineering in UC San Diego's Jacobs School of Engineering constructed a 3-D model of the structure of the lamprey estrogen receptor.
|Contact: Debra Kain|
University of California - San Diego