Navigation Links
Evolution is driven by gene regulation
Date:8/13/2007

New Haven, Conn. It is not just whats in your genes, its how you turn them on that accounts for the difference between species at least in yeast according to a report by Yale researchers in this weeks issue of Science.

Weve known for a while that the protein coding genes of humans and chimpanzees are about 99 percent the same, said senior author Michael Snyder, the Cullman Professor of Molecular Cellular and Developmental Biology at Yale. The challenge for biologists is accounting for what causes the substantial difference between the person and the chimp.

Conventional wisdom has been that if the difference is not the gene content, the difference must be in the way regulation of genes produces their protein products.

Comparing gene regulation across similar organisms has been difficult because the nucleotide sequence of DNA regulatory regions, or promoters, are more variable than the sequences of their corresponding protein-coding regions, making them harder to identify by standard computer comparisons.

While many molecules that bind DNA regulatory regions have been identified as transcription factors mediating gene regulation, we have now shown that we can functionally map these interactions and identify the specific targeted promoters, said Snyder. We were startled to find that even the closely related species of yeast had extensively differing patterns of regulation.

In this study, the authors found the DNA binding sites by aiming at their function, rather than their sequence. First, they isolated transcription factors that were specifically bound to DNA at their promoter sites. Then, they analyzed the sequences that were isolated to determine the similarities and differences in regulatory regions between the different species.

By using a group of closely and more distantly related yeast whose sequences were well documented, we were able to see functional differences that had been invisible to researchers before, said Snyder. We expect that this approach will get us closer to understanding the balance between gene content and gene regulation in the question of human-chimp diversity.


'/>"/>

Contact: Janet Rettig Emanuel
janet.emanuel@yale.edu
203-432-2157
Yale University
Source:Eurekalert

Related biology news :

1. Molecular biology fills gaps in knowledge of bat evolution
2. Same mutation aided evolution in many fish species, Stanford study finds
3. Researchers trace evolution to relatively simple genetic changes
4. Family trees of ancient bacteria reveal evolutionary moves
5. Great White shark evolution debate involves WSU Lake Campus geology professor
6. Revolutionary nanotechnology illuminates brain cells at work
7. The evolutionary triumph of flower power
8. To Stop Evolution: New Way Of Fighting Antibiotic Resistance Demonstrated By Scripps Scientists
9. MicroRNAs play a big part in gene regulation - and evolution
10. Enlisting genomics to understand flu evolution
11. Evolution of taste receptor may have shaped human sensitivity to toxic compounds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/3/2016)... and DE SOTO, Kansas , March ... Detection Plus® to offer Oncimmune,s Early CDT®-Lung, a ... early detection of lung cancer Early CDT®-Lung ... and individuals. --> Early CDT®-Lung test to ... --> Oncimmune, a leader in early cancer ...
(Date:3/2/2016)... 2, 2016 http://www.researchandmarkets.com/research/cmt3hk/global_biometrics ... "Global Biometrics as a Service Market ... --> http://www.researchandmarkets.com/research/cmt3hk/global_biometrics ) has announced ... as a Service Market 2016-2020" report ... Research and Markets ( http://www.researchandmarkets.com/research/cmt3hk/global_biometrics ) has ...
(Date:3/1/2016)... -- (RSAC Booth #3041) – True fraud costs business $9 ... lost to false positives, where good customers are pushed ... the RSA Conference 2016, NuData Security is calling for a ... devaluing the data fraudsters have in abundance in favor ... --> --> Cheap and readily available ...
Breaking Biology News(10 mins):
(Date:4/29/2016)... ... 2016 , ... During a two day program for start-up ... CereScan’s CEO, John Kelley, joined other Denver business leaders in providing business basics ... Denver area business community, shared his top fundamental learnings in building an effective, ...
(Date:4/28/2016)... PUNE, India , April 28, 2016 ... PT, JT, Stirling, and Brayton Cryocoolers), Service (Technical Support, ... Application, and Geography - Global Forecast to 2022", published ... to USD 2.94 Billion by 2022, at a CAGR ... Browse 70 market data Tables and 94 Figures spread ...
(Date:4/28/2016)... York, NY (PRWEB) , ... April 28, 2016 ... ... QuickSTAT has made significant investments in recruiting top industry experts, and expanding its ... Platform, which provides industry-leading tools for clients to manage their clinical trial projects. ...
(Date:4/27/2016)... ... , ... The Pittcon Organizing Committee is pleased to announce that Charles “Chuck” ... of Committee since 1987. Since then, he has served in a number of key ... for both the program and exposition committees. In his professional career, Dr. Gardner is ...
Breaking Biology Technology: