Navigation Links
Evolution is driven by gene regulation

New Haven, Conn. It is not just whats in your genes, its how you turn them on that accounts for the difference between species at least in yeast according to a report by Yale researchers in this weeks issue of Science.

Weve known for a while that the protein coding genes of humans and chimpanzees are about 99 percent the same, said senior author Michael Snyder, the Cullman Professor of Molecular Cellular and Developmental Biology at Yale. The challenge for biologists is accounting for what causes the substantial difference between the person and the chimp.

Conventional wisdom has been that if the difference is not the gene content, the difference must be in the way regulation of genes produces their protein products.

Comparing gene regulation across similar organisms has been difficult because the nucleotide sequence of DNA regulatory regions, or promoters, are more variable than the sequences of their corresponding protein-coding regions, making them harder to identify by standard computer comparisons.

While many molecules that bind DNA regulatory regions have been identified as transcription factors mediating gene regulation, we have now shown that we can functionally map these interactions and identify the specific targeted promoters, said Snyder. We were startled to find that even the closely related species of yeast had extensively differing patterns of regulation.

In this study, the authors found the DNA binding sites by aiming at their function, rather than their sequence. First, they isolated transcription factors that were specifically bound to DNA at their promoter sites. Then, they analyzed the sequences that were isolated to determine the similarities and differences in regulatory regions between the different species.

By using a group of closely and more distantly related yeast whose sequences were well documented, we were able to see functional differences that had been invisible to researchers before, said Snyder. We expect that this approach will get us closer to understanding the balance between gene content and gene regulation in the question of human-chimp diversity.


Contact: Janet Rettig Emanuel
Yale University

Related biology news :

1. Molecular biology fills gaps in knowledge of bat evolution
2. Same mutation aided evolution in many fish species, Stanford study finds
3. Researchers trace evolution to relatively simple genetic changes
4. Family trees of ancient bacteria reveal evolutionary moves
5. Great White shark evolution debate involves WSU Lake Campus geology professor
6. Revolutionary nanotechnology illuminates brain cells at work
7. The evolutionary triumph of flower power
8. To Stop Evolution: New Way Of Fighting Antibiotic Resistance Demonstrated By Scripps Scientists
9. MicroRNAs play a big part in gene regulation - and evolution
10. Enlisting genomics to understand flu evolution
11. Evolution of taste receptor may have shaped human sensitivity to toxic compounds
Post Your Comments:
(Date:4/6/2017)... 2017 Forecasts by Product Type ... by End-Use (Transportation & Logistics, Government & Public Sector, ... Fossil Generation Facility, Nuclear Power), Industrial, Retail, Business Organisation ... Are you looking for a definitive report on the ... ...
(Date:4/5/2017)... April 4, 2017 KEY FINDINGS ... expand at a CAGR of 25.76% during the forecast ... the primary factor for the growth of the stem ... MARKET INSIGHTS The global stem cell ... application, and geography. The stem cell market of the ...
(Date:3/30/2017)... 2017  On April 6-7, 2017, will host ... hackathon at Microsoft,s headquarters in Redmond, ... on developing health and wellness apps that provide a ... Genome is the first hackathon for personal genomics ... companies in the genomics, tech and health industries are ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... , ... October 11, 2017 , ... ... gene in its endogenous context, enabling overexpression experiments and avoiding the use of ... small RNA guides is transformative for performing systematic gain-of-function studies. , This ...
(Date:10/11/2017)... BioMarketing, a leading provider of patient support solutions, has announced ... network, which will launch this week. The VMS CNEs will ... to enhance the patient care experience by delivering peer-to-peer education ... professionals to help women who have been diagnosed and are ... ...
(Date:10/11/2017)... , ... October 11, 2017 , ... ... (FDA) has granted orphan drug designation to SBT-100, its novel anti-STAT3 (Signal Transducer ... treatment of osteosarcoma. SBT-100 is able to cross the cell membrane and bind ...
(Date:10/10/2017)... ... 10, 2017 , ... Dr. Bob Harman, founder and CEO of VetStem ... The event entitled “Stem Cells and Their Regenerative Powers,” was held ... Harman, DVM, MPVM was joined by two human doctors: Peter B. Hanson, M.D., Chief ...
Breaking Biology Technology: