Navigation Links
Evolution in action: Our antibodies take 'evolutionary leaps' to fight microbes
Date:1/5/2009

With cold and flu season in full swing, the fact that viruses and bacteria rapidly evolve is apparent with every sneeze, sniffle, and cough. A new report in the January 2009 issue of The FASEB Journal (http://www.fasebj.org), explains for the first time how humans keep up with microbes by rearranging the genes that make antibodies to foreign invaders. This research fills a significant gap in our understanding of how the immune system helps us survive.

"We've known for a long time that our antibody-forming system adapts itself to every microbe we encounter," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal, "but what we didn't understand fully is exactly how this happens. Now that we know, we can begin to find ways to manipulate this process so illnesses can be prevented or made significantly less dangerous."

When the body encounters a foreign invader, like a virus or bacterium, it immediately begins to find a way to neutralize it by means of cellular or antibody-mediated defenses. Part of the process involves tailoring the genes that code for antibodies to specific viruses or bacteria. Researchers have known that this involves two types of genetic manipulation. One type changes a single gene at a time, and the other type changes multiple genes at the same time. In the report, scientists from Wayne State University in Detroit describe how multiple genes can be modified simultaneously to make the "evolutionary leap" necessary to stave off infection. The basic setup of the experiment treated DNA responsible for making antibody molecules with an enzyme, called activation-induced deaminase, while the DNA was being copied by RNA polymerase. Like a scanner, RNA polymerase moves across the DNA to copy it. When this scanning process moved smoothly, there were either single mutations or no mutations. When the researchers made the RNA polymerase stall along the DNA (under certain conditio
'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. A simple fusion to jump-start evolution
2. Breast cancer genome shows evolution, instability of cancer
3. Orangutans spontaneous whistling opens new chapter in study of evolution of speech
4. Biogeography, changing climates and niche evolution
5. Using water to understand human society, from the industrial revolution to global trade
6. Scientists shed light on evolution of gene regulation
7. Flies may reveal evolutionary step to live birth
8. Discovery of giant roaming deep sea protist provides new perspective on animal evolution
9. Two from one: Pitt research maps out evolution of genders from hermaphroditic ancestors
10. Evolutions new wrinkle
11. Forced evolution: Can we mutate viruses to death?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... of the amphibians with the highest distribution in the ... water where it comes into contact with the red ... out by the Spaniard Germn Orizaola from the University ... frogs have developed a defensive response to the invasive ... if they co-exist with the crayfish. , Numerous invasive ...
(Date:7/9/2014)... laboratory testing, countless measurement results accrue. To completely ... extremely time consuming. In fact, researchers in the ... managing data, according to an online survey of ... the Fraunhofer Institute for Applied Information Technology FIT ... that they have no centralized or structured approach ...
(Date:7/9/2014)... inhibitors and N-methyl-D-aspartate receptor antagonists can alleviate ... to affect irreversible cognitive dysfunction and effectively ... Amyloid beta peptide (Aβ) vaccines reduced and ... (AD) transgenic mouse model, and significantly improved ... and his team, First Affiliated Hospital of ...
Breaking Biology News(10 mins):Frogs have developed rapid defences against the red swamp crayfish 2Frogs have developed rapid defences against the red swamp crayfish 3Managing the data jungle 2Managing the data jungle 3
... researchers have sequenced the genomes of two bacteria that ... Brazil and elsewhere. , The researchers are now analysing ... that could be used to develop vaccines and diagnostic ... in pigs and costs the Brazilian pig-breeding industry US$200 ...
... once were bountiful in an area near the town of ... grew more plentiful, browsing heavily on young willows. Today, there ... warblers in what is now a grassland meadow. These profound ... top predator. That's the compelling finding of the paper, "Human ...
... of boosting the yield of a major crop by stopping ... is the most important oilseed crop in India after groundnut. ... seeds. However, because the seedpods open naturally to disperse their ... , This 'pod shatter' also makes it difficult for farmers ...
Cached Biology News:Wolves' top-down effect 2
(Date:1/15/2014)... 2014 The Pittcon Organizing Committee is pleased ... Safety Tech , an e-Journal and producer of ... the second year for the co-location of Food Labs Conference ... provides that the registration fee to attend the two-day Food ...
(Date:1/15/2014)... 2014 ­ RedBrick Health , a fast-growing leader ... announces that EmblemHealth , the New ... now providing the RedBrick Compass health assessment, combined with ... of its members. EmblemHealth is among the first health ...
(Date:1/15/2014)... The Microcompetition with Foreign DNA theory explains how ... latent viruses is the Epstein Barr Virus (EBV), and one ... is a chronic inflammatory disease that destroys the body’s joints. ... patients have high concentrations of EBV DNA in their bodies ...
(Date:1/15/2014)... TaiGen Biotechnology Company, Limited ("TaiGen") today announced that ... leading Russian pharmaceutical company, to develop and commercialize nemonoxacin ... , Turkey and other ... novel antibiotic for the treatment of bacterial infections including ...
Breaking Biology Technology:Pittcon Announces Second Year Partnership With Food Safety Tech 2Pittcon Announces Second Year Partnership With Food Safety Tech 3EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 3Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4
... Editors note: This is the first of a series of columns ... and advice on IT leadership and the challenges they face. ... 95 percent of his customers want more of what he has ... ready to meet that demand. , ,David Wallace is the CIO ...
... arteries. Source: National Institutes of Health. Madison, Wis. ... researcher, announced on Wednesday that it will receive a $1.26 ... National Institutes of Health. , ,The funds will be used ... anemia, a blood disorder that kills red blood cells. This ...
... getting a flu shot this season and you want to fix ... mirror. If the face you see belongs to someone who buys ... the problem. , ,The looming shortage of flu vaccine comes down ... in the business of making vaccines. Why? The capital costs are ...
Cached Biology Technology:MATC faces demand for less paper and more integration 2MATC faces demand for less paper and more integration 3Mirus receives $1.26 million SBIR grant to combat anemia 2Want to squeeze U.S. pharmaceutical companies? Be careful what you ask for 2Want to squeeze U.S. pharmaceutical companies? Be careful what you ask for 3
... amino acid synthetic peptide whose sequence is from rat SCAMP 5. ... C - N(217) - Q - P - Q - ... - P - N - Y - T - Y - ... neutralization and control experiments with the polyclonal antibody that reacts with ...
... output accessory lessens the expensive task ... laboratories with multiple mass spectrometers. It ... from Agilent 1100 Series LC/MSD quadrupole ... transmits the analog data directly to ...
... DSQ II (Dual-Stage Quadrupole) Thermo Scientific ... leader in analytical instrumentation, introduces the latest ... DSQ II. Based on the proven reliability ... PolarisQ GC/MS systems, the DSQ II incorporates ...
... variant: With the macro- and ... and Skoog (1962) and the ... et al. (1968). Preparation Quantity ... grams of powder per liter ...
Biology Products: