Navigation Links
Evolution can select for evolvability, Penn biologists find
Date:11/14/2013

e VlsE gene is preceded by "cassettes" which are normally not expressed, or made into individual proteins, but can recombine with VlsE to alter the expressed protein and thus present a novel challenge to a host's immune defenses.

Though earlier studies had suggested that selection may directly favor the capacity to evolve, they could not definitively rule out that evolvability had arisen for other reasons. In particular, it has been difficult in empirical studies to rule out the possibility that evolvability arises and is maintained as a byproduct of selection on organismal features more directly related to fitness.

In the Lyme disease system, the researchers got around this confounding factor by looking at diversity in the unexpressed cassettes, which would not have been the object of direct selection because they have no known function on their own; they simply exist as a way of increasing the potential diversity of the VlsE protein. Thus diversity in the cassettes would offer a window into past natural selection for a more "evolvable" VlsE.

"Organisms with greater diversity among the cassettes will have a selective advantage as they will be more antigenically evolvable, or better able to repeatedly generate novel antigens, and will thus be more likely to persist within hosts," the researchers wrote.

Using long-established methods in molecular evolution, the researchers evaluated 12 strains of B. burgdorferi for signs that natural selection had acted to increase the diversity of the cassettes.

"The evidence was remarkably strong in favor of evolution for more diversity among cassettes and thus greater evolvability in the expressed protein," Brisson said.

The researchers confirmed that the more genetically diverse the cassettes, the more genetically diverse the expressed protein, VlsE. They also found that mutations in the cassettes that could affect the portion of VlsE that is recognized by the immune
'/>"/>

Contact: Katherine Unger Baillie
kbaillie@upenn.edu
215-898-9194
University of Pennsylvania
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Penn team elucidates evolution of bitter taste sensitivity
2. Fast-mutating DNA sequences shape early development; guided evolution of uniquely human traits
3. Targeting evolution: Could this be the next strategy to stop superbugs?
4. Alfred Russel Wallace: Co-founder of the theory of biological evolution
5. Climate change and coevolution: Weve done the math
6. Grazers and pollinators shape plant evolution
7. Evolutionary medicine of skin cancer risk among Europeans
8. Recent highlights in Molecular Biology and Evolution
9. Fear of holes may stem from evolutionary survival response
10. Penn biologists show that generosity leads to evolutionary success
11. Biometrics Can Revolutionise Mobile Payment Security, says Frost & Sullivan
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/18/2015)... , Feb. 18, 2015  Cepheid (NASDAQ: ... at the following conferences, and invited investors to participate via ... Boston, MA Tuesday, March 3, 2015 at ... Conference, Orlando, FL Wednesday, March 4, ... Webcasts To access the live webcasts for these events, please ...
(Date:2/12/2015)... , Feb. 12, 2015 NXT-ID, Inc. (NASDAQ: ... "Company"), a biometric authentication company focused on the growing ... provisional patent 62/113114 for DISTRIBUTED METHOD AND ... The patent further establishes NXT-ID,s position in the ... property portfolio the ability for multiple devices to collaborate ...
(Date:2/9/2015)... 9, 2015  Lintec of America recently announced an ... nanotube (CNT) macrostructures, including sheets, yarns and ribbons, developed ... Leveraging the vast industrial resources of the global ... , Lintec of America is forming the Nano-Science and ... , focusing on scaling up the manufacturing and commercialization ...
Breaking Biology News(10 mins):Cepheid to Webcast Upcoming Financial Presentations 2NXT-ID Patents Collaborative Services to Enable the "Internet of Things" 2NXT-ID Patents Collaborative Services to Enable the "Internet of Things" 3Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 2Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 3Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 4
... French colonial-style exterior of the National Cancer Hospital in Hanoi, ... hospitals crowded wards, treatment rooms and corridors, doctors are struggling ... the disease is winning. Each year in this country ... cancer and another 150,000 new cases are diagnosed. Figures are ...
... United States die every year from uncontrolled infections of ... pushing the boundaries of molecular science to find new ... measure of an immune system protein within 24 hours ... can predict survival in children, yielding a powerful tool ...
... in Germany have discovered that methadone, an agent used ... power against leukemia cells, including treatment resistant forms of ... August 1 issue of Cancer Research , a ... that methadone holds promise as a new therapy for ...
Cached Biology News:In Vietnam, alongside progress, a battle for life 2In Vietnam, alongside progress, a battle for life 3Immune system protein accurate predictor of survival in pediatric septic shock 2Immune system protein accurate predictor of survival in pediatric septic shock 3Lab study shows methadone breaks resistance in untreatable forms of leukemia 2
(Date:3/6/2015)... Ashland, VA (PRWEB) March 06, 2015 ... of sodium hydroxide concentration by utilizing laboratory refractometers. ... soda) is used in producing a variety of products ... strong base is a staple of the chemical industry; ... to petroleum – and nearly everything in between. ...
(Date:3/5/2015)... SAN FRANCISCO , March 5, 2015  Twelve ... two-day, six-way kidney paired donation transplant at California Pacific ... Physicians here believe this procedure will be the ... West Coast and the largest conducted in the 44-year ... procedure today and tomorrow began with an altruistic donor ...
(Date:3/5/2015)... 05, 2015 BioPlus Specialty Pharmacy (BioPlus) ... of Vice President of Managed Care. In this role, ... one of the nation’s leading specialty pharmacies. , Damm, ... years of specialty pharmacy and biotech experience to his ... Pharmaceuticals, Vertex Pharmaceuticals, and Pfizer. Prior to working in ...
(Date:3/5/2015)... , March 5, 2015  UBM Medica ... , a leading online community to help oncologists ... the newest information available regarding the use of ... kidney cancer. March is National ... very few effective adjuvant treatment options for renal ...
Breaking Biology Technology:Altruistic donor starts large West Coast single-center kidney paired donation at CPMC 2Altruistic donor starts large West Coast single-center kidney paired donation at CPMC 3Altruistic donor starts large West Coast single-center kidney paired donation at CPMC 4BioPlus Specialty Pharmacy Announces Hiring of New Vice President of Managed Care: Jamie Damm 2OncoTherapy Network Highlights Kidney Cancer Awareness Month 2OncoTherapy Network Highlights Kidney Cancer Awareness Month 3
... recently participated in a roundtable discussion with HR executives ... talent management and resourcing strategies for elite multinational firms. ... how to make the work place and the workforce ... to make sure that companies always have the right ...
... its release of GroupWise Migrator for Exchange Version 2.2, ... of server and desktop data from Novell GroupWise to ... for Exchange could convert mail, archives, personal address books, ... Exchange. The new version adds the ability to migrate ...
... The time has come to reexamine the federal policy on ... itself at the center of this debate, because our state ... In 1998, Dr. Jamie Thomson at the University ... the first time, successfully isolated stem cells from human embryos ...
Cached Biology Technology:Stuck in Talent Gridlock 2Stuck in Talent Gridlock 3Wingra Technologies releases new e-mail-message migration software 2Gov. Doyle comments on unlocking the power of power of stem cell research 2Gov. Doyle comments on unlocking the power of power of stem cell research 3
... interferons are cytopathic effect inhibition assays, also known ... include; tissue culture supernatents; serum from PK studies ... unit is defined as the quantity of interferon ... of viral infection by 50%. All ...
...
Request Info...
...
Biology Products: