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Evidence of host adaptation of avian-origin influenza A virus
Date:5/14/2013

be essential for pathogenicity in cases of airborne viral transmission. This substitution was observed for the first time at this site in H7N9, which may indicate a novel host adaptation feature of the H7 virus.

Findings from the current study implied a rapid evolution of the novel H7N9 virus. This may assist in determining the source and mode of transmission of these infections, and provide a reference for selecting candidate vaccine strains. The receptor binding properties of Q226I and the significance of the substitutions in H7N9 need further exploration, including both in vitro and in vivo experiments, and extensive field surveillance.


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Contact: YAN Bei
yanbei@scichina.org
86-106-400-8316
Science China Press
Source:Eurekalert

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