Navigation Links
Evidence of harmful effect of bisphenol A-based plastics

Bisphenol A impairs the function of proteins that are vital for growth processes in cells. This finding has been reported by researchers from the Ruhr-Universitt Bochum and the University of Wuppertal. The substance, short BPA, is contained in many plastic products and is suspected of being hazardous to health. To date, it had been assumed that bisphenol A produces a harmful effect by binding to hormone receptors. The chemist and biochemist team has discovered that the substance also affects the so-called small GTPases. They published their findings in the "Journal of Medicinal Chemistry".

Complex mechanism of action

"Our research provides further evidence that the physiological effects of bisphenol A may be even more complex than previously assumed," says Prof Dr Raphael Stoll, head of Biomolecular Spectroscopy at the Ruhr-Universitt. "However, we have also discovered other related compounds that indicate which path the future development of pharmaceutically effective substances against GTPase-mediated tumours may take," adds synthetic chemist Prof Dr Jrgen Scherkenbeck from Wuppertal.

Bisphenol A impairs the function of GTPases

Small GTPases are enzymes that occur in two states within the cell: in the active form when bound to the GTP molecule; and in the inactive form when bound to GDP, a lower-energy form of GTP. These switch proteins are crucial for transmitting signals within the cell. The researchers have demonstrated that bisphenol A binds to two different small GTPases, K-Ras and H-Ras, thereby preventing the exchange of GDP for GTP. The non-profit organisation German Cancer Aid (Deutsche Krebshilfe e. V.) has financed the project since 2011.

Bisphenol A is a suspected health hazard

Various organisations have pointed out that bisphenol A may be hazardous to health: the Federal Institute for Risk Assessment (Bundesinstitut fr Risikoforschung), the European Food Safety Authority, the US Food and Drug Administration (FDA), the US National Institutes of Health (NIH) and the US-American Breast Cancer Foundation. However, those organisations have not yet provided a final assessment of the substance's hazardous potential. Nevertheless, the European Commission banned the use of bisphenol A in the manufacture of baby bottles in 2011. Academic studies indicate that the substance may increase the risk of cardiovascular diseases, breast and prostate cancer as well as neuronal diseases. The researchers therefore recommend a restriction of bisphenol A-based plastic containers for food products.


Contact: Dr. Raphael Stoll
Ruhr-University Bochum

Related biology news :

1. Blind cavefish offer evidence for alternative mechanism of evolutionary change
2. CU-Boulder-led team finds first evidence of primates regularly sleeping in caves
3. New evidence suggests Neanderthals organized their living spaces
4. Evidence of 3.5 billion-year-old bacterial ecosystems found in Australia
5. No evidence to support stem cell therapy for pediatric optic nerve hypoplasia
6. New evidence that cancer cells change while moving throughout body
7. Exploring the Latest Evidence of Dairys Contribution to Nutrition at IUNS Satellite Symposium
8. New evidence for warm-blooded dinosaurs
9. Evidence suggests Antarctic crabs could be native
10. ACRG and BGI report new evidence for the genetic bases of liver cancer
11. First international collaboration to showcase latest body of evidence of dairy health benefits
Post Your Comments:
(Date:10/26/2015)... , October 26, 2015 ... --> adds Biometrics Market ... 2021 as well as Emerging Biometrics ... reports to its collection of IT ... . --> ...
(Date:10/26/2015)... , Oct. 26, 2015  Delta ID Inc., ... authentication to mobile and PC devices, announced its ActiveIRIS® ... the arrows NX F-02H launched by NTT DOCOMO, INC ... F-02H is the second smartphone to include iris recognition ... in ARROWS NX F-04G in May 2015, world,s first ...
(Date:10/23/2015)... GOLETA, California , October 23, 2015 ... and SensoMotoric Instruments (SMI) announce a mobile plug and ... captured during interactive real-world tasks SensoMotoric Instruments ... of their established wearable solutions for eye tracking and ... behavior captured with SMI Eye Tracking Glasses 2w ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... ... 24, 2015 , ... Copper is an essential micronutrient that ... proteins, copper is also toxic to cells. With a $1.3 million award from ... conduct a systematic study of copper in the bacteria Pseudomonas aeruginosa (P. aeruginosa), ...
(Date:11/24/2015)... -- Clintrax Global, Inc., a worldwide provider of clinical research services headquartered ... the company has set a new quarterly earnings record in Q3 ... posted for Q3 of 2014 to Q3 of 2015.   ... , with the establishment of an Asia-Pacific ... United Kingdom and Mexico , with ...
(Date:11/24/2015)... Muncie, IN (PRWEB) , ... November 24, 2015 , ... ... its newest Special Interest Group (SIG), MultiGP, also known as Multirotor Grand Prix, to ... in the last few years. Many AMA members have embraced this type of racing ...
(Date:11/24/2015)... TEL AVIV, Israel , Nov. 24, 2015  Tikcro Technologies Ltd. ... be held on December 29, 2015 at 11:00 a.m. Israel ... & Co., Electra Tower, 98 Yigal Allon Street, 36 th Floor, ... , election of Eric Paneth and Izhak Tamir ... and Rami Skaliter as external directors; , approval of an ...
Breaking Biology Technology: