Navigation Links
Evidence of harmful effect of bisphenol A-based plastics
Date:1/10/2014

Bisphenol A impairs the function of proteins that are vital for growth processes in cells. This finding has been reported by researchers from the Ruhr-Universitt Bochum and the University of Wuppertal. The substance, short BPA, is contained in many plastic products and is suspected of being hazardous to health. To date, it had been assumed that bisphenol A produces a harmful effect by binding to hormone receptors. The chemist and biochemist team has discovered that the substance also affects the so-called small GTPases. They published their findings in the "Journal of Medicinal Chemistry".

Complex mechanism of action

"Our research provides further evidence that the physiological effects of bisphenol A may be even more complex than previously assumed," says Prof Dr Raphael Stoll, head of Biomolecular Spectroscopy at the Ruhr-Universitt. "However, we have also discovered other related compounds that indicate which path the future development of pharmaceutically effective substances against GTPase-mediated tumours may take," adds synthetic chemist Prof Dr Jrgen Scherkenbeck from Wuppertal.

Bisphenol A impairs the function of GTPases

Small GTPases are enzymes that occur in two states within the cell: in the active form when bound to the GTP molecule; and in the inactive form when bound to GDP, a lower-energy form of GTP. These switch proteins are crucial for transmitting signals within the cell. The researchers have demonstrated that bisphenol A binds to two different small GTPases, K-Ras and H-Ras, thereby preventing the exchange of GDP for GTP. The non-profit organisation German Cancer Aid (Deutsche Krebshilfe e. V.) has financed the project since 2011.

Bisphenol A is a suspected health hazard

Various organisations have pointed out that bisphenol A may be hazardous to health: the Federal Institute for Risk Assessment (Bundesinstitut fr Risikoforschung), the European Food Safety Authority, the US Food and Drug Administration (FDA), the US National Institutes of Health (NIH) and the US-American Breast Cancer Foundation. However, those organisations have not yet provided a final assessment of the substance's hazardous potential. Nevertheless, the European Commission banned the use of bisphenol A in the manufacture of baby bottles in 2011. Academic studies indicate that the substance may increase the risk of cardiovascular diseases, breast and prostate cancer as well as neuronal diseases. The researchers therefore recommend a restriction of bisphenol A-based plastic containers for food products.


'/>"/>

Contact: Dr. Raphael Stoll
raphael.stoll@rub.de
49-234-322-5466
Ruhr-University Bochum
Source:Eurekalert

Related biology news :

1. Blind cavefish offer evidence for alternative mechanism of evolutionary change
2. CU-Boulder-led team finds first evidence of primates regularly sleeping in caves
3. New evidence suggests Neanderthals organized their living spaces
4. Evidence of 3.5 billion-year-old bacterial ecosystems found in Australia
5. No evidence to support stem cell therapy for pediatric optic nerve hypoplasia
6. New evidence that cancer cells change while moving throughout body
7. Exploring the Latest Evidence of Dairys Contribution to Nutrition at IUNS Satellite Symposium
8. New evidence for warm-blooded dinosaurs
9. Evidence suggests Antarctic crabs could be native
10. ACRG and BGI report new evidence for the genetic bases of liver cancer
11. First international collaboration to showcase latest body of evidence of dairy health benefits
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/1/2017)... Massachusetts , February 1, 2017 IDTechEx ... events on emerging technology, announces the availability of a new report, ... Continue Reading ... ... in industrial and collaborative robots. Source: IDTechEx Report "Sensors for Robotics: ...
(Date:1/25/2017)... , Jan. 25, 2017 The Elements of ... (IAM) lifecycle is comprised of a comprehensive set ... purpose of maintaining digital identities and providing a ... applications. There are significant number of programs opted ... to time by optimizing processes and changing policies. ...
(Date:1/19/2017)... 19, 2017 According to a new report published by ... - 2022," the global biometric sensor market is expected to garner $1.5 billion ... 2015, Asia-Pacific dominated the global market and contributed over ... Continue Reading ... ...
Breaking Biology News(10 mins):
(Date:2/22/2017)... Dublin - Research and Markets has announced ... Type, By Application, By End User, By Region, By Country: Opportunities ... ... is forecasted to grow at a CAGR of 11.33% during 2016-2021. ... protection market is driven by the surging demand for less toxic ...
(Date:2/22/2017)... ... February 22, 2017 , ... ... of Tom Perkins as European director. Operating from Pennside’s Zurich headquarters, Pennside Partners, ... , Perkins joins Pennside after more than a decade with leading market research ...
(Date:2/21/2017)... - SQI Diagnostics Inc. ("SQI" or the "Company") (TSX-V: SQD; OTCQX: ... months ended December 31, 2016. SQI is ... company that develops and commercializes proprietary technologies and products for ... ... milestones achieved in fiscal 2016," said Andrew Morris , ...
(Date:2/21/2017)... San Francisco, CA (PRWEB) , ... February 21, ... ... is pleased to announce that Dr. Trevor Heritage has joined its executive team ... a revolutionary system designed to provide insights to help improve the diagnosis and ...
Breaking Biology Technology: