Navigation Links
Evidence now suggests eating soy foods in puberty protects against breast cancer
Date:4/9/2008

pubertal exposure to genistein are very consistent in showing a reduction in mammary cancer risk, she says. Exposure to soy in fetal development or in adult life does not have the same protective effect.

Further examination of experimental versus control rats demonstrated that use of genistein in puberty cut the number of so-called terminal end buds in the breast. These are the structures that lead to growth of the mammary epithelium, which are the cells lining milk ducts, etc., and it is in these epithelial cells that breast cancer originates. But Hilakivi-Clarke says it is not clear if a mere reduction in the number of these structures could reduce cancer risk, or why.

Other studies suggest that genistein controls expression of genes in terminal end buds that regulate cell growth, repair and death. For example, the chemical could be controlling the ability of stem cells, found on these buds, to reproduce themselves or to differentiate into more specialized cells. There is evidence that suggests that the more stem cells there are on these structures, the greater the risk of breast cancer development, she says. This evidence supports the theory that breast cancer arises from stem cells that have lost growth control.

Other associated research has found that the genes that genistein appears to activate in developing mammary glands are well known --- BRCA1, p53, and PTEN tumor suppressors, Hilakivi-Clarke says. These genes repair genetic damage and control cell survival and death, and they may also help control stem cell reproduction, she says, and genistein apparently up-regulates these genes, boosting production of their beneficial proteins.

What is perhaps most intriguing, she says, is that the same process that protects the breast from excess growth during pregnancy seems to be at work during puberty. In pregnancy, BRCA1 is also up-regulated, perhaps in order to control the fate of stem cells, allowing them to make more cells for
'/>"/>

Contact: Karen Mallet
km463@gmail.com
414-312-7085
Georgetown University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. A private bandwidth for communication in bats: Evidence from insular horseshoe bats
2. Comet probes reveal evidence of origin of life, scientists claim
3. Evidence of a relationship between swimming babies and infections
4. Researchers find evidence linking stress caused by the Sept. 11 disaster with low birth weights
5. Fossil record supports evidence of impending mass extinction
6. New evidence for female control in reproduction
7. RAND study finds evidence disease management programs
8. CWRU School of Medicine has evidence vaccine against malaria will reduce disease
9. There is powerful evidence of evolution in human DNA
10. Scientific evidence supporting evolution continues to grow
11. No convincing evidence for decline in tropical forests
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... FASEB MARC (Maximizing Access to Research Careers) Program ... Genetics Society of America,s 27th Annual Mouse Molecular ... 2014 in Pacific Grove, California. These awards ... post doctorates and scientists from underrepresented groups into ... to encourage the participation of young scientists at ...
(Date:8/28/2014)... (Maximizing Access to Research Careers) Program has announced ... of Sports Medicine,s Conference on Integrative Physiology of ... These awards are meant to promote the ... underrepresented groups into the mainstream of the basic ... young scientists at the American College of Sports ...
(Date:8/28/2014)... in German . ... with the help of sophisticated assembly lines. Mobile assembly carriers, ... part of these assembly lines. In the case of a ... stages arranged in a precise spatial and chronological sequence, resulting ... , The creation of such an assembly line at molecular ...
Breaking Biology News(10 mins):Nanoscale assembly line 2Nanoscale assembly line 3
... the nervous system may thrive by disrupting cell function ... and spread to other cells. Princeton University researchers ... of the herpes virus indirectly take control of a ... energy supply, communication with other cells, and self-destruction response ...
... SAN FRANCISCO -- Researchers looking into the value ... after an eight-week program, study participants demonstrated improved ... and increased strength and endurance. The study, ... Medical Center in Indianapolis, Indiana University-Purdue University Indianapolis ...
... gas the ultimate fuel for stars is lurking ... Braun has found.,This is the first accurate measurement of this ... the Big Bang the Universe,s matter was almost entirely hydrogen ... generated galaxies, stars and planets and the process is ...
Cached Biology News:To spread, nervous system viruses sabotage cell, hijack transportation 2To spread, nervous system viruses sabotage cell, hijack transportation 3To spread, nervous system viruses sabotage cell, hijack transportation 4Study: In-patient, out-patient stroke rehab might benefit from yoga 2There's more star-stuff out there but it's not dark matter 2
(Date:8/28/2014)... 2014  Next month, executives from clinical trial marketing firm ... beginning with Patient-Centered Clinical Trials 2014 , to be ... , September 4-5. Patient recruitment experts Bonnie A. ... will share insights on the benefits of employing an ... – from media to mobile apps – can be used ...
(Date:8/28/2014)... Exciting new work by a Florida State University research ... can take your temperature, emit white light, and convert ... molecule looks like a butterfly. , Biwu Ma, associate ... in the FAMU-FSU College of Engineering, created the molecule ... continued to discover that his creation has many other ...
(Date:8/28/2014)... 2014 PrimeSource Building Products, Inc., ... SoundConnect to support their communication needs ... and web conferencing platform GlobalMeet powered by SoundConnect. ... needs. SoundConnect delivers award winning “results driven” ... Products will be utilizing GlobalMeet powered by ...
(Date:8/27/2014)... Green & Grow Inc. (GGI) has ... and secured Otter Capital as a significant new partner. ... of GGI’s Agriplier™ technology, building on recent compelling field ... our first meeting, we have been impressed with Otter ... said Alan Sobba, President and CEO of GGI. “We ...
Breaking Biology Technology:BBK Worldwide Leads Sessions at Key September Events 2Novel 'butterfly' molecule could build new sensors, photoenergy conversion devices 2PrimeSource Chooses SoundConnect as Collaboration Provider 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 3
... M. Adams and R. Deadman , ... , GE Healthcare offers a range ... A combination of these kits with the Genesis Freedom™ Robotic Sample Processor (RSP) from ... ...
... Key words: cAMP • ... • assay miniaturization , ... the largest family of transmembrane receptors and are responsible for the transduction ... marketed drugs are active at this receptor family; however, these drugs exhibit ...
... , ... Measurement of receptor internalization using the pH-sensitive cyanine dye, ... this dye that shows greater relative fluorescence intensity when maximally ... enhanced dye, CypHer5E, is a red-excited, pH-sensitive fluorogenic dye that ...
Cached Biology Technology:Automation of TempliPhi and GenomiPhi DNA Amplification Kits on the Genesis Freedom Robotic Sample Processor 2Automation of TempliPhi and GenomiPhi DNA Amplification Kits on the Genesis Freedom Robotic Sample Processor 3Development of a sensitive enzyme fragment complementation assay for cyclic adenosine 3', 5' monophosphate and its validation for pharmacological screening at G protein-coupled receptors 2Development of a sensitive enzyme fragment complementation assay for cyclic adenosine 3', 5' monophosphate and its validation for pharmacological screening at G protein-coupled receptors 3Development of a sensitive enzyme fragment complementation assay for cyclic adenosine 3', 5' monophosphate and its validation for pharmacological screening at G protein-coupled receptors 4Development of a sensitive enzyme fragment complementation assay for cyclic adenosine 3', 5' monophosphate and its validation for pharmacological screening at G protein-coupled receptors 5Development of a sensitive enzyme fragment complementation assay for cyclic adenosine 3', 5' monophosphate and its validation for pharmacological screening at G protein-coupled receptors 6The use of CypHer5E and the IN Cell Analyzer 1000 for live-cell receptor internalization studies 2The use of CypHer5E and the IN Cell Analyzer 1000 for live-cell receptor internalization studies 3The use of CypHer5E and the IN Cell Analyzer 1000 for live-cell receptor internalization studies 4The use of CypHer5E and the IN Cell Analyzer 1000 for live-cell receptor internalization studies 5The use of CypHer5E and the IN Cell Analyzer 1000 for live-cell receptor internalization studies 6