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Evidence mounts for role of mutated genes in development of schizophrenia
Date:1/22/2013

xtensions.

"We showed that the mutation does change the function of NPAS3, with potentially harmful effects in neurons," he says. "The next step is to figure out exactly how the genetic disruption alters neuronal function, and how these abnormal neurons influence the broader function of the brain."

Nucifora and his team are now working to create a mouse with the NPAS3 mutation. "If this mutation in NPAS3 is indeed important for human disease, then we should detect abnormalities in the neurons of mice with mutant NPAS3, and the mice should have impairments in learning, memory and social behavior," he says.


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Contact: Stephanie Desmon
sdesmon1@jhmi.edu
410-955-8665
Johns Hopkins Medicine
Source:Eurekalert

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