Navigation Links
Everest expedition suggests nitric oxide benefits for intensive care patients
Date:10/6/2011

The latest results from an expedition to Mount Everest that looked at the body's response to low oxygen levels suggest that drugs or procedures that promote the body's production of a chemical compound called nitric oxide (NO) could improve the recovery of critically ill patients in intensive care.

Oxygen is required by all larger organisms, including humans, to survive. Many critically ill patients suffer from a shortage of oxygen (a condition known as 'hypoxia'), which can be life-threatening. NO is produced by virtually every cell and organ in the body where it serves many important functions including the regulation of blood pressure, learning and memory formation, and protecting us from infectious diseases.

This work, the product of collaboration between scientists at UCL and the University of Warwick, made use of blood samples and results collected during the 2007 Caudwell Xtreme Everest (CXE) expedition. The results show that NO production and activity are elevated in people who live at near sea-level altitudes ('lowlanders') that ascend to altitude, leading to changes in blood flow in the smallest blood vessels.

Published today in Scientific Reports, the new open access journal from Nature Publishing Group, the paper suggests that interventions to alter NO production some of which already exist in the form of drugs or gas may benefit critically ill patients in whom oxygen availability is limited.

This is the first time such effects have been documented in a larger group of lowlanders and is consistent with earlier data from residents of the Tibetan plateau ('highlanders') showing their normal NO levels to be much elevated compared to people living near sea-level. Doctors believe increased NO may be beneficial for people, particularly patients with low levels of oxygen in their blood, because it increases the body's ability to tolerate and adapt to a low oxygen supply.

The paper is based on expe
'/>"/>

Contact: Kate Cox
kate.cox@warwick.ac.uk
44-247-615-0483
University of Warwick
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scientists climb Mt. Everest to explain how hearts adapt and recover from low oxygen
2. A wild and woolly discovery: FSU scientists Tibetan expedition ends with prehistoric find
3. Meltzone 2011: CCNY expedition to track life and death of supraglacial lake
4. Woods Hole Oceanographic Institution leads expedition to measure radioactive contaminants in Pacific
5. California Academy of Sciences launches scientific expedition to the Philippines
6. Malaspina 2010, the biggest ever expedition on global change, sets sail
7. Highlight of the Polarstern expedition
8. Malaspina expedition 2010
9. Expedition to Mid-Cayman Rise identifies unusual variety of deep sea vents
10. British scientific expedition discovers worlds deepest known undersea volcanic vents
11. Expedition heads for worlds deepest undersea volcanoes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/14/2015)... YORK , May 14, 2015 /PRNewswire/ ... in identity verification and online remote proctoring, ... a software-as-a-service (SaaS) company and creator of ... customers of the two companies will benefit ... in Canvas. As a fully ...
(Date:5/11/2015)... , May 11, 2015 Curemark LLC, ... the start of a new Phase III double blind, ... its novel formulation, CM-AT, on all children ages 3-8 ... its FDA Phase III double blinded clinical trial for ... low levels of the digestive enzyme chymotrypsin. This new ...
(Date:5/7/2015)... , May 7, 2015 ... fingerprint sensors, FPC1022 and FPC1035, FPC,s smallest touch ... FPC1035 are mainly considered for integration on the ... gives smartphone OEMs increased possibilities to integrate touch ... decreased size also improves possibilities for module manufacturers ...
Breaking Biology News(10 mins):Verificient and Instructure Announce Alliance Partnership to Provide Online Proctoring for K-12 and Higher Education Institutions 2Curemark, LLC, Launches New Phase III Trial in Expanded Population of Children with Autism 2FPC Introduces its Smallest Touch Fingerprint Sensors to Date 2
... nutrients that can negatively impact aquatic ecosystems and human ... streams and aquifers across the Nation since the early ... U.S. Geological Survey. "This USGS report provides the ... phosphorus in our streams and groundwater," said Marcia McNutt, ...
... since victory gardens helped World War II era Americans ... gardens been as necessary and popular as they are ... of the produce grown there becomes increasingly important. ... and vegetables for family consumption and planning ahead for ...
... report by the International Osteoporosis Foundation (IOF) show alarming ... in the Russian Federation and many other countries in ... press conference in St. Petersburg at the IOF Summit ... Osteoporosis, a disease of the bone which leaves ...
Cached Biology News:Elevated nitrogen and phosphorus still widespread in much of the nation's streams and groundwater 2Elevated nitrogen and phosphorus still widespread in much of the nation's streams and groundwater 3Urban gardeners beware: There may be lead in your soil and food 2High death and disability rates due to fractures in Russia, Central Asia and Eastern Europe 2
(Date:6/2/2015)... , June 02, 2015 Research ... of Jain PharmaBiotech,s new report "Biomarkers - ... This report follows the broad definition ... be objectively measured and evaluated as an indicator ... as pharmacological responses to a therapeutic intervention. Tests ...
(Date:6/2/2015)... June 2, 2015   Y-Prime, Inc ., ... BIO Exhibition 2015 in Philadelphia ... largest biotechnology gathering, allows influential decision makers from ... they can evaluate emerging technologies such as YPrime. ... in the design, implementation and management of Interactive ...
(Date:6/2/2015)... June 2, 2015  RXi Pharmaceuticals Corporation ... focused on discovering and developing innovative therapies ... ophthalmology, today announced that Dr. Pamela Pavco ... at the 23 rd World Congress ... will include in-depth presentations by world-class clinicians ...
(Date:6/2/2015)... , June 2, 2015 ... the global antibiotic resistance problem  MGB ... class of anti-infectives, to address the major global ... has developed a stable intravenous (IV) formulation of MGB-BP-3, ... resistant Gram-positive hospital-acquired infections.  The intravenous formulation ...
Breaking Biology Technology:Global Biomarkers Market Report 2015 - Technologies, Markets and Companies Analysis and Forecasts 2014-2024 2Global Biomarkers Market Report 2015 - Technologies, Markets and Companies Analysis and Forecasts 2014-2024 3YPrime at BIO Exhibition in Philadelphia and DIA in Washington DC during the month of June 2RXi Pharmaceuticals to Present at the 23rd World Congress of Dermatology 2RXi Pharmaceuticals to Present at the 23rd World Congress of Dermatology 3RXi Pharmaceuticals to Present at the 23rd World Congress of Dermatology 4MGB Biopharma Succeeds in Developing an IV Formulation of MGB-BP-3 for the Treatment of Systemic Susceptible and Resistant Gram-Positive Hospital-Acquired Infections 2MGB Biopharma Succeeds in Developing an IV Formulation of MGB-BP-3 for the Treatment of Systemic Susceptible and Resistant Gram-Positive Hospital-Acquired Infections 3
... ... TSX Exchange Symbol: RVX, CALGARY, July 9 /PRNewswire-FirstCall/ - ... RVX-208 has been selected as one of the top 10 ... an,independent committee assembled by Windhover Information, a leading,provider of business ...
... ... - Aggressive acquisition ... Worldwide Clinical,Trials, Inc.("WCT"), formed by Dr. Neal R. Cutler and a team ... research organization with the announcement that it has closed the,acquisition of MediQuest, ...
... ImQuest Life Sciences announced,today the successful acquisition of ... the mechanism of action of their dual-acting,pyrimidinedione HIV ... Innovative Research (SBIR) award will allow ImQuest,scientist to ... HIV. IQP-0410 has been determined to primarily inhibit ...
Cached Biology Technology:Industry Leaders Select Resverlogix's RVX-208 2Industry Leaders Select Resverlogix's RVX-208 3Worldwide Clinical Trials Emerges as Leading Global Contract Research Organization 2Worldwide Clinical Trials Emerges as Leading Global Contract Research Organization 3ImQuest Awarded SBIR Grant to Define the Mechanism of Action of Their Lead Anti-HIV Therapeutic Compound IQP-0410 2
4-Hydroxy-3-nitrophenylacetyl hapten is conjugated to KLH (Keyhole Limpet Hemocyanin) lysine through amide bonds....
4-Hydroxy-3-nitrophenylacetyl hapten is conjugated to SSA (Sheep serum albumin) lysine through amide bonds. This product is homologous to NP-BSA....
...
Human Aminopeptidase P2/XPNPEP2 Affinity Purified PAb ENTREZ GeneID: 7512...
Biology Products: