Navigation Links
Even healthy pregnant women need to worry about oral bacteria
Date:5/10/2010

Even healthy pregnant women can be at risk for pregnancy problems caused by oral bacteria. Researchers from Case Western Reserve University began to understand which bacteria from the 700 species living in the mouth are responsible for the growing health problem of preterm and stillbirths.

Yiping Han from the department of periodontics in the CWRU School of Dental Medicine led the study, which found several new bacteria originating in the mouth travel through the blood to cause an inflammatory reaction in the placenta and eventually cause a range of health issues from miscarriages to stillbirths.

The findings were reported this month in Infection and Immunity.

Pregnant women with or without mild oral health problems have baffled researchers as to why oral bacteria have shown up in the placenta or amniotic fluids of premature or stillbirths.

The researchers found that after injecting the tails of pregnant mice with saliva from healthy people and dental plaque from those with periodontal disease, oral bacteria continued to grow in the placentas after it had left the blood 24 hours later.

Prior to Han's work in connecting oral bacteria to the problems in pregnancy, it was thought that infections were transmitted through the vaginal tract.

Information from Han's previous studies over the past decade shows that oral bacteria can be transported through the blood when there is a cut in the mouth's lining or an oral health problem like gingivitis or periodontitis which breaks down the defenses in the mouth's lining that protect bacteria from entering the bloodstream.

According to Han, this suggests that even healthy pregnant women should be concerned that normally occurring bacteria in the mouth can enter the blood stream and make their way into the placenta's immune-free environment to ignite an inflammatory reaction that can lead to premature or stillbirths.

"We found many bacteria did locate to the placenta, but they were not the most famous periodontal pathogens," said Han. "In fact, many of the bacteria were the kind that are found in healthy people's mouths." These include Streptococcus, Leptotricia, Fusobacterium nucleautm, Veillenella, among others.

The researchers are finding that many of the bacteria found in the placentas cannot be grown in the lab, which has been the gold standard. They are identified through DNA cloning techniques that match the bacteria in the placenta with the bacteria found in the mouth. This DNA fingerprinting allows researchers to trace the origin of the bacteria.

Hans notes that as long as these bacteria stay in the mouth, they cause very little problems. However in the uterus, they stimulate the inflammatory response that leads to cervical and membrane weaknesses and ruptures and uterine contractions.

In several case studies, Han said the mothers did not have a pronounced periodontal disease or periodontitis. The mothers did have a form a pregnancy-associated gingivitis, which resulted from changes in the hormones, and disappears after the birth of the baby.

"The normal healthy woman is under risk," Han said. "People should be concerned about it. This is what the experiment is showing."

She added, "We need to know which bacteria colonize in the placenta and design therapies for better treatments."

These are the kinds of bacteria that are with us all our lives, and only cause disease when the opportunity arises, Han said.

She added, "What is happening with the oral bacteria colonizing in the placenta happens with other diseases that triggers an inflammatory response."

During CWRU Research ShowCASE 2010, Yann Fardini, one of the paper's researchers, received honors for his presentation on the research.


'/>"/>

Contact: Susan Griffith
susan.griffith@case.edu
216-368-1004
Case Western Reserve University
Source:Eurekalert

Related biology news :

1. Creating new healthy ingredients by innovative milling techniques and processes for cereal grains
2. New biotech advance to add heart healthy omega-3s to US diet
3. Americans want Uncle Sams help putting healthy foods on their dinner table
4. Bacterial balance that keeps us healthy
5. Participaton important for healthy marine parks
6. Scientists identify critical enzyme in healthy heart function
7. Play yourself healthy
8. Enzyme necessary for development of healthy immune system
9. Vermicompost from pig manure grows healthy hibiscus
10. How nutrition affects healthy aging
11. New neuroimaging analysis technique identifies impact of Alzheimers disease gene in healthy brains
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/3/2016)... 4, 2016 --> --> ... M (105.0), up 1,187% compared with fourth quarter of 2014. ... 517.6 M (loss: 30.0). Earnings per share increased to SEK ... 537.4 M (neg: 74.7). , --> ... to SEK 2,900.5 M (233.6), up 1,142% compared with 2014. ...
(Date:2/2/2016)... Feb. 2, 2016 This BCC Research ... market by reviewing the recent advances in high ... drive the field forward. Includes forecast through 2019. ... the challenges and opportunities that exist in the ... solution developers, as well as IT and bioinformatics ...
(Date:2/1/2016)... 2016 Rising sales of consumer ... touchfree intuitive gesture control market size ... of consumer electronics coupled with new technological advancements to ... size through 2020   --> ... technological advancements to drive global touchfree intuitive gesture control ...
Breaking Biology News(10 mins):
(Date:2/9/2016)... ... 09, 2016 , ... Clinovo , the cloud-based eClinical ... Data Capture (EDC) system ClinCaptureand its new Contract Research Organization (CRO) Partner Program ... in San Mateo, California on February 10th and 11th. Watch 2-min video ...
(Date:2/9/2016)... ... 09, 2016 , ... PharmApprove announced today the ... Organization for Rare Disorders (NORD). Dorman will lead PharmApprove efforts to work with ... the drug regulatory review process. , “Adding Diane Dorman is just the latest ...
(Date:2/9/2016)... 2016 Three-Year Initiative Supports Next Generation ... Part in Life-Changing Camp Experiences ... positively affect the lives of children born with rare diseases, as ... SHPG ) is announcing a new initiative designed to positively affect ... the future of rare disease care. --> To mark ...
(Date:2/8/2016)... Should antibiotic bone cement products be used ... infection after standard total hip or knee replacement surgery? ... have been fielding a lot lately. "Antibiotic ... --> "Antibiotic Bone Cement: Fighting ... --> While there isn,t a simple answer, ECRI ...
Breaking Biology Technology: