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Evaluating evolutionary rates could shed light into functions of uncharacterized genes
Date:2/8/2013

essary DNA sequences.

"A key question is: How important is that gene at that time?" he said. "If a species encounters a new challenge in its environment, the genes associated with it might have to evolve through subsequent generations in order to adapt that important pathway and ensure species survival."

By tracking those complementary rate changes, it could be possible to identify which genes participate in the same important pathways, providing clues to their function.

"In the future, a researcher studying a particular disease process might be able to plug in a couple of known genes in a database of evolutionary rate changes to find others that have a parallel history," Dr. Clark said. "That could provide new insight into the workings of the biological pathway of interest."


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Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

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