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Europe's most common genetic disease is a liver disorder
Date:2/6/2008

e blood stream and reduces iron uptake in the intestine.

HFE influences hepcidin expression through a series of intermediate molecules, but when the HFE gene is mutated the result is that less hepcidin is produced. This in turn means iron uptake in the intestine cannot be limited as effectively and an overload develops, says Martina Muckenthaler, professor at the University of Heidelberg.

The research is a landmark for the joint Molecular Medicine Partnership Unit of EMBL and the University of Heidelberg. The Unit is dedicated to elucidating the molecular mechanisms of a range of different diseases, among which disorders of iron metabolism constitute a central focus.


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Contact: Anna-Lynn Wegener
wegener@embl.de
49-622-138-7452
European Molecular Biology Laboratory
Source:Eurekalert

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