Navigation Links
European-wide study confirms benefits of D-penicillamine and trientine for Wilson disease
Date:3/31/2011

Results from the first ever European-wide retrospective analysis presented today at the International Liver CongressTM have shown both D-penicillamine and trientine continue to be effective treatments, providing positive survival rates in patients with Wilson disease free from a liver transplant.

Wilson disease is a rare genetic storage disorder in which copper is not excreted by the body effectively, leading to excess copper build up, liver failure and damage to the brain (neurological problems). Worldwide the condition, affects approximately one in 30,000 people. If not treated, Wilson disease can be chronically debilitating and life threatening. While current guidelines recommend the use of chelating agents (D-penicillamine, trientine) as first line therapy of symptomatic patients, optimal treatment regimens are yet to be established.

In this retrospective multicentre cohort study the long-term outcomes of treatment with D-penicillamine and trientine were reviewed in 347 patients with the condition. Changes of medication were common in both groups and resulted in a total of 467 analysed treatments (D-penicillamine, n=326, trientine n=141). Following an average follow-up of 16.5 years, both treatments provided a similar and excellent survival rate and prevented disease progression with the need for liver transplantation in over 98% of patients.

Daniele Prati, EASL's Scientific Committee Member and Press Committee Chairman commented: "Not only does this study show that both treatments are effective options for patients with this rare and often debilitating condition, but it is also encouraging to see how European countries can work together and exchange data which is extremely valuable to guide best practice and evaluate existing treatment regimens. Research on rare liver diseases presents remarkable interest."

"To date, a very limited number of drugs for these conditions are marketed, leaving the majority of rare diseases w
'/>"/>

Contact: Dimple Natali
easlpressoffice@cohnwolfe.com
44-790-013-8904
European Association for the Study of the Liver
Source:Eurekalert

0

GOOD

Page: 1 2

Related biology news :

1. UC Riverside researcher receives $9 million USDA grant to study potato and tomato disease
2. New study shows you can have your candy and eat it too -- without adverse health effects
3. Study: Emissions trading doesnt cause pollution hot spots
4. Butterfly study reveals traits and genes associated with establishment of new populations
5. Study shows hunger hitting closer to home
6. Most states unclear about storage, use of babies blood samples, new study finds
7. GPS study shows wolves more reliant on a cattle diet
8. Russian boreal forests undergoing vegetation change, study shows
9. Spicing up your love life possible, study finds
10. Study finds weight training safe for pregnant women
11. Study predicts large regional changes in farmland area
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... year, carrying more than 284 million tons of cargo, transit ... in toll fees for the Panama Canal Authority. Each time ... water are used from Gatun Lake, which is also a ... the isthmus. , However, the advent of very large ... ships at sea, has demanded change. The Panama Canal is ...
(Date:5/23/2013)... unnecessarily undergo surgery or harsh treatments because science ... aggressive forms of the disease. Researchers at Case ... are developing technology that allows patients to safely ... treatments or take drastic measures. , The project ... professor of biomedical engineering at Case Western Reserve ...
(Date:5/23/2013)... the team reveal the interplay of brain chemicals which ... Wellcome Trust and BBSRC. , By changing the ... perceptual abilities. While these changes can affect the strength ... fidelity of that response. , Lead author ... communicate with others, you can make yourself better heard ...
Breaking Biology News(10 mins):Reforestation study shows trade-offs between water, carbon and timber 2Reforestation study shows trade-offs between water, carbon and timber 3Using big data to identify prostate cancers and best treatments 2Using big data to identify prostate cancers and best treatments 3
... PHILADELPHIA Researchers at Kaiser Permanente have found that patients ... in situ or DCIS) who have higher mammographic density may ... the breast opposite to the one with the initial cancer. ... Epidemiology, Biomarkers & Prevention , a journal of the American ...
... discovery of a hormone acting like molecular glue could hold ... plants cope with environmental stress. The study, which is ... reveals how the plant hormone jasmonate binds two proteins together ... chemistry. The study also identifies the receptor,s crystal structure to ...
... Climbers of high peaks such as Mount Kilimanjaro are at ... ignore AMS warning signs, which can progress to more serious ... altitude sickness by becoming acclimatized to increased altitudes before an ... High Altitude Medicine & Biology , a peer-reviewed journal ...
Cached Biology News:Breast density linked to increased risk of subsequent breast cancer 2Hormone acting as 'molecular glue' could boost plant immune systems 2
(Date:5/23/2013)... The New Jersey chapter of the largest organization ... (BDPA), is hosting its 10th annual Families in Technology ... will encourage students and their parents to explore the ... many of the industries’ finest teachers. Held from 9 ... of Technology, the event will include workshops, instruction and ...
(Date:5/23/2013)... DIEGO , May 23, 2013  Verenium Corporation ... company focused on the development and commercialization of high-performance ... , Chief Financial Officer, will present at two upcoming ... Mr. Black will present at the Second Annual Marcum ... the Grand Hyatt Hotel in New York City.  The ...
(Date:5/23/2013)... , May 23, 2013 Pusan ... Inc., a private biotherapeutics and contract research company ... products for cancer, announced today a publication reporting ... treated with the oncolytic and immunotherapeutic vaccinia JX-594 ... research was published in the May 15 th ...
(Date:5/23/2013)... 23, 2013 African Ancestry ... for people of African descent, today announced new ... For people of all races, myDNAmix determines various ... distinct populations: Indigenous Americas (Native American), East Asia, ... , Originally launched in late 2011, ...
Breaking Biology Technology:Black Data Processing Associates (BDPA) New Jersey Hosts 10th Annual Families in Technology Day June 8, 2013 2Verenium To Present At Two Upcoming Conferences 2Verenium To Present At Two Upcoming Conferences 3Pusan National University Announces Science Translational Medicine Publication Highlighting Landmark Demonstration of Functional Anti-Cancer Antibody Induction in Patients Following JX-594 Treatment 2Pusan National University Announces Science Translational Medicine Publication Highlighting Landmark Demonstration of Functional Anti-Cancer Antibody Induction in Patients Following JX-594 Treatment 3AfricanAncestry.com Rolls Out Improved MyDNAMix Admixture Test for People of all Races; Enhancements Increase Accuracy in Estimation of Ancestral Makeup 2AfricanAncestry.com Rolls Out Improved MyDNAMix Admixture Test for People of all Races; Enhancements Increase Accuracy in Estimation of Ancestral Makeup 3
... Grove Heights, Minn The two- and three-port Gigabit ... made only for the Apple G5 platform have arrived ... announced Monday. , ,"There are many multiple platform configurations ... Corky Seeber, Small Tree's president. "Having a single networking ...
... MADISON - Ohio State University's new "living laboratory" ... media-presentation system developed by Madison-based Sonic Foundry, ... view instructors' presentations, the company announced Monday. , ... to provide Ohio State with data for making ...
... Firstlogic, Inc. announced Thursday it has gained ... with the United States Postal Service 's National ... latest version of Firstlogic's product Mover I.D. has been ... NCOALink is designed to help organizations keep mailing lists ...
Cached Biology Technology:Small-Tree extends G5 networking platform to G4, Windows and Linux 2Ohio State's educational tech lab to use Sonic Foundry system 2
... water bath, with a comprehensive array of ... water baths with seamless, splash-water protected keypad ... MULTI-DISPLAY (LED) indicating up to 6 temperature ... Advanced MICROPROCESSOR technology with PID temperature control ...
... The new TC-412 thermal cycler, flexible on ... TC-412 is a high performance, high sample throughput ... Features: , Flexible block format: The truly ... be exchanged in a matter of seconds without ...
Preparation Note: by a modification of the procedure of C.W. Hancher et al., Biotechnol. Bioeng. 11, 1055 (1969) Assay: ~ 20 A 260 /mg Solubility: water 10 mg/mL, clear, light-yellow Suitab tst...
A collection of 42 spots with normal tissues from different organs of C57 mice, rat and human....
Biology Products: