Navigation Links
European Research Council supports search for regulators of tissue damage
Date:1/27/2012

There is more to fighting infection than just clearing the body of pathogens. As important as resisting infection, is limiting damage to the host's tissue caused, very frequently, by toxins produced by pathogens or by components of the host immune response that clears those pathogens. Indeed, it is the damage inflicted to different tissues and organs that, if uncontrolled, can lead to the lethal outcome of some infectious diseases.

The in-built capacity that an infected individual has to limit the extent of tissue damage caused by different pathogens, a phenomenon known as 'tolerance to infection', has fascinated Miguel Soares, a group Leader at the Instituto Gulbenkian de Cincia (IGC) in Portugal, for several years. Now, the European Research Council (ERC) has awarded his team an Advanced Grant of just over 2,2 million Euros, to investigate the mechanisms involved in this protective response. This line of research should identify and pave the way to the development of new therapeutic interventions, to quell the clinical outcome of various diseases.

Miguel Soares and his research team have already identified a restricted number of mechanisms, regulated by specific genetic programmes that control tissue damage in response to different types of infection. They have shown that these protective mechanisms are active for example against severe forms of malaria and severe sepsis. The researchers believe, however, that other protective mechanisms controlled by groups of so-called "protective genetic programmes" can act in a similar manner in the context of different diseases. Their aim is to identify these protective mechanisms, and describe how the genetic programs act, so that these may be targeted to treat a whole range of infectious diseases.

Says Miguel Soares, "Infectious diseases such as malaria and severe sepsis remain medical challenges today, acting as major killers across the globe. Our data suggest that one of the reasons for
'/>"/>

Contact: Ana Godinho
agodinho@igc.gulbenkian.pt
351-214-407-959
Instituto Gulbenkian de Ciencia
Source:Eurekalert  

Page: 1 2

Related biology news :

1. European Geosciences Union General Assembly, April 22-27, 2012, Vienna, Austria
2. Cell Therapeutics, Inc. Expects That the European Medicines Agencys (EMA) Committee for Medicinal Products for Human Use (CHMP) May Issue an Opinion on the Marketing Authorization Application ("MAA") on Pixuvri™ in Mid-February
3. European mountain vegetation shows effects of warmer climate
4. DTU is participating in a European network on measurement of greenhouse gases
5. Register now for the European Congress on Osteoporosis & Osteoarthritis in Bordeaux
6. UK invests £75 million in European research infrastructure to support knowledge-based economy
7. EMBO awards Installation Grants to 7 European scientists
8. How does a plant survive with few mates or pollinators? A European herb has figured out its own way
9. New European project launched to address shortcomings in climate data
10. Misleading morphology: 3 European parasitoid wasp species are seasonal forms of just 1
11. Genomatix to partner in $41 million European epigenomics consortium
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
European Research Council supports search for regulators of tissue damage
(Date:9/18/2014)... celebrated tonight at the third annual Golden Goose Award ... premature infants and in paving the way for the ... supported by the National Science Foundation, the National Institutes ... be honored at a ceremony at the Library of ... of Congress will be on hand to help present ...
(Date:9/18/2014)... of the fish world, are the ideal animal in ... They,ve moved from the ocean into tens of thousands ... time changing their skeleton to adapt to the new ... of sticklebacks now have turned up one of the ... simple change in that gene,s regulation in a freshwater ...
(Date:9/17/2014)... were instrumental in the creation of the Santa Ana ... the fire threat potential of the powerful, hot, dry ... an inferno. The index was introduced Sept. 17 by ... San Diego Gas and Electric. , The index includes ... will be used to help fire agencies and other ...
Breaking Biology News(10 mins):3rd annual Golden Goose award ceremony honors 8 researchers; Unusual work had big results 2Counting fish teeth reveals regulatory DNA changes behind rapid evolution, adaptation 2Counting fish teeth reveals regulatory DNA changes behind rapid evolution, adaptation 3UCLA scientists play key role in developing new Santa Ana Wildfire Threat Index 2
... 15, 2011 -- Sing it with us: What lives in the ... new species of mushroom almost as strange as its cartoon namesake. ... Francisco State University researcher Dennis Desjardin, suggests that even some of ... be identified. Shaped like a sea sponge, S. squarepantsii ...
... research papers that have been recently published in ... (GRL), Journal of Geophysical Research-Atmospheres (JGR-D), ... Geophysical Research-Oceans (JGR-C). In this release:, ... Surge in North Atlantic hurricanes due to better detectors, ...
... press conference on Monday 11 July at University of Edinburgh ... the world meet next month in Edinburgh (11-15 July) to ... the first time in over 20 years, the Scientific Committee ... Symposium of Antarctic Earth Sciences (ISAES) in the UK. ...
Cached Biology News:'SpongeBob' mushroom discovered in the forests of Borneo 2'SpongeBob' mushroom discovered in the forests of Borneo 3AGU journal highlights -- June 15, 2011 2AGU journal highlights -- June 15, 2011 3AGU journal highlights -- June 15, 2011 4AGU journal highlights -- June 15, 2011 5AGU journal highlights -- June 15, 2011 6AGU journal highlights -- June 15, 2011 7AGU journal highlights -- June 15, 2011 8AGU journal highlights -- June 15, 2011 9AGU journal highlights -- June 15, 2011 10AGU journal highlights -- June 15, 2011 11AGU journal highlights -- June 15, 2011 12
(Date:9/18/2014)... LOUIS , Sept. 18, 2014  U.S. biotech ... by signing an exclusive license for technology developed by ... control gene expression in plants, including for applications in ... The technology was developed under the ... officer at Kultevat and former president of the Danforth ...
(Date:9/18/2014)...  Neogen Corporation (Nasdaq: NEOG ) announced ... with Merck Animal Health to market Neogen,s Igenity ® ... Dairy Heifer Program consists of genomic tests that offer ... of replacement dairy heifers. The genomic tests can be ... an excellent tool in the decision-making process for breeding ...
(Date:9/18/2014)... YARDLEY , Pennsylvanie, 18 septembre 2014 ... Lyon en 1974, a été ... à compléter les évaluations cliniques traditionnelles par ... Reported Outcomes) et sur les impacts économiques ... http://photos.prnewswire.com/prnh/20140618/119365 A cours ...
(Date:9/18/2014)... OMICS Group International invites researchers, authors and ... ‘Open Access Week’ by actively contributing their research ... Journals from 20-26th October, 2014. , Pharmaceutical ... accelerating with a tremendous speed to provide improved ... industry is gearing with innovation and technological revolution ...
Breaking Biology Technology:Kultevat obtains license of gene switch technology 2Merck Animal Health to market Neogen's dairy genomic program 21974 - 2014 - Mapi fête ses 40 ans 2Pharma and Omics Journals to Address Global Challenges during Open Access Week 2Pharma and Omics Journals to Address Global Challenges during Open Access Week 3
... University of Wisconsin-Madison faculty have created a new dual-degree ... students how to apply such knowledge to problems in ... and aggression," says Clark Miller, a professor of science ... the new program. "Or what about brain mechanisms that ...
... agricultural equipment manufacturer Gehl Co. has developed a ... boom functions using a compact, wireless remote control pendant from ... The hand-held pendant can be used to raise, lower, extend ... , ,"Our goal was to add a new dimension ...
... -- Thomas Record, a biophysical chemist at the University ... Society Fellows by the Biophysical Society, a 7,000-member U.S. ... professor of chemistry and biochemistry, Record hopes that the ... students and extramural funding for his research. , ,A ...
Cached Biology Technology:UW offers new program in neuroscience and public policy 2
...
Agarose for baculovirus plaque assays which allow optimal growth of plated insect cells....
BD BaculoGold Max-XP Insect Cell Medium 1 Liter...
Mycoplasma and virus tested...
Biology Products: