Navigation Links
Europe is joining forces against neglected parasitic diseases
Date:3/4/2014

The project involves 10 European partners, 5 Brazilian partners (who operate in the region where the diseases are endemic) and 2 Australian partners. They will all be meeting on 17 and 18 March at the Institute of Genetics and Molecular and Cellular Biology (Inserm / CNRS / University of Strasbourg Joint Research Unit), to get the project started.

Schistosomiasis, leishmaniasis, Chagas disease and malaria are regarded as neglected diseases because the effort and funds put into developing new treatment and control methods have not been commensurate with their catastrophic human impact. They affect people in developing countries, essentially in Africa, the Middle East, South America and eastern Asia, in tropical and sub-tropical regions. Around one billion people are regularly exposed to these diseases, which cause almost one million deaths every year.

At present, there is no vaccine against these parasites. Furthermore, the efficacy of existing treatments is limited, either by the side effects or by the current or potential development of resistance. Consequently, the A-PARADDISE consortium, which is coordinated by Inserm and headed by Raymond Pierce - Director of Research at the Centre for Infection and Immunity in Lille - is focusing on developing new drugs against these parasitoses.

The A-PARADDISE project will use a methodology that has already been tried and tested during a previous project of a similar scale (SEtTReND), which aimed to develop drugs against schistosomiasis. The researchers investigated histone-modifying enzymes (HME), which determine the structure of the parasite's chromosomes. It was demonstrated that some HME inhibitors induce cell death, which makes them toxic to this parasite. This research provided the proof of concept that HMEs act on the schistosomiasis parasite, and has led to the development of a bank of candidate compounds which can rapidly be tested against other human parasites.

Thanks t
'/>"/>

Contact: Raymond Pierce
Raymond.Pierce@pasteur-lille.fr
33-320-877-783
INSERM (Institut national de la sant et de la recherche mdicale)
Source:Eurekalert

Page: 1 2

Related biology news :

1. European flood risk could double by 2050
2. Researchers shed new light on the genetic history of the European beaver
3. European Union launches Nordic climate innovation center
4. Unique new dataset CLIMBER: Climatic niche characteristics of the butterflies in Europe
5. Are invasive plants a problem in Europe? Controversial views among invasion biologists
6. Scandinavia joins European Unions main climate innovation initiative
7. Blue eyes and dark skin, thats how the European hunter-gatherer looked
8. European epilepsy consortium identifies new gene for severe childhood epilepsy
9. Meloidogyne mali: A new invasive plant parasitic nematode in Europe
10. Aspartame passes stiff review by European Food Safety Authority
11. Europes rarest orchid rediscovered on lost world volcano in the Azores
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/12/2015)... As the digital payment services ... advanced biometrics technology is accelerating beyond expectations.  While the ... using their credit cards, the digital currency, mobile payment ... services led by companies in the space such as ... (NASDAQ: GOOG ), Apple Inc. (NASDAQ: AAPL ...
(Date:8/12/2015)... 12, 2015  Synaptics Inc. (NASDAQ: SYNA ... today announced that four of its fingerprint ID ... officially been named FIDO Certified™ by the Fast ... certification, Synaptics, Natural ID™ fingerprint solutions are fully ... (UAF) standard and are interoperable among other products ...
(Date:8/10/2015)... TELTOW, Germany , August 10, 2015 ... a world leader in Eye Tracking Technology for more ... OEM Eye Tracking Platform for integration into all consumer ... reference designs for seamless integration of eye tracking into ... HMDs and augmented reality smart glasses. Omnivision,s leading sensor ...
Breaking Biology News(10 mins):Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 2Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 4Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 5Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 6Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 2Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 3SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 2SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 3
... of Marine Geology and Geophysics at the University of Miami ... off the fall semester with the inauguration of sophisticated equipment ... manner. Stable isotopes are used by biogeochemists to help ... using small organisms found in sediment cores. ...
... October issue of Infection Control and Hospital Epidemiology, ... uses a famous case of international intrigue and murder to ... while treating patients with radiation poisoning. The study ... Litvinenko, the Russian dissident and former KGB operative who died ...
... delivered directly to a particularly stubborn type of breast ... of recurrence and helps increase the effectiveness of some ... MD Anderson Cancer Center reported in the Sept. 13 ... and mouse studies, scientists found the gene mutation BikDD ...
Cached Biology News:'Clumps' of opportunities for cutting edge science 2Polonium poisoning case sheds light on infection control practices 2Gene therapy kills breast cancer stem cells, boosts chemotherapy 2Gene therapy kills breast cancer stem cells, boosts chemotherapy 3
(Date:8/31/2015)... 31, 2015 Research and Markets ( http://www.researchandmarkets.com/research/cbgl72/middle_east_and ... East & Africa Biomedical Sensors Market - Growth, Trends ... The Middle East ... billion by 2018 at a CAGR of 3.26% over ... bring Biomedical sensors that are adaptable to the genetic ...
(Date:8/31/2015)... Aug. 31, 2015 /PRNewswire/ - Portage Biotech Inc. ("Portage" ... PBT.U), is pleased to announce that its wholly owned ... lead candidate, PPL-003, to an Investigational New Drug (IND) ... and uveitis.  PPL recently completed a study in a ... solution achieved highly significant efficacy and a more rapid ...
(Date:8/31/2015)... -- US-Australian drug discovery company, Novogen Limited (ASX: NRT; ... scientific review has identified high value opportunities for ... patient need. Novogen is moving as quickly as ... entering into Phase 1 clinical trials with our ... Officer, Iain Ross , said that following ...
(Date:8/31/2015)... SOUTH SAN FRANCISCO, Calif. , Aug. 31, 2015 ... on the discovery and development of novel cancer immunotherapies, ... , M.D., Ph.D., as Chief Executive Officer and ... Drs. Wong and Ho join an experienced management team ... company: Jordan Fridman , Ph.D., Chief Scientific Officer; ...
Breaking Biology Technology:Middle East & Africa Biomedical Sensors Market Report 2015 - Growth, Trends & Forecasts to 2020 2Portage's PPL will advance its lead candidate PPL-003 to an IND for dry eye disease and uveitis 2Portage's PPL will advance its lead candidate PPL-003 to an IND for dry eye disease and uveitis 3Novogen Announces The Outcome Of A Comprehensive Science Review 2Novogen Announces The Outcome Of A Comprehensive Science Review 3Novogen Announces The Outcome Of A Comprehensive Science Review 4Novogen Announces The Outcome Of A Comprehensive Science Review 5Novogen Announces The Outcome Of A Comprehensive Science Review 6FLX Bio Announces Senior Management Hires and Initiation of Phase 1 Trial of FLX925 2FLX Bio Announces Senior Management Hires and Initiation of Phase 1 Trial of FLX925 3FLX Bio Announces Senior Management Hires and Initiation of Phase 1 Trial of FLX925 4
... ... to provide online tutorial suite, Quick Reference Cards, and other training and outreach programs. ... Seattle, WA (PRWEB) April 13, ... has partnered with OpenHelixTM to provide comprehensive training and outreach programs for its ...
... Researchers at Uppsala University have developed a new method ... Hopes are strong that the method represents an important ... new diagnostic tests. The new method, which ... should enable studies of the effects of genetic variation ...
... ... Deliver Results Faster with New User Interface and Improved Support for Complex Experiments. ... (PRWEB) April 12, ... life science research, today announced Genedata Screener® 8. Developed over the past year to ...
Cached Biology Technology:RCSB PDB Teams with OpenHelix to Announce Free Tutorial and Training Materials 2RCSB PDB Teams with OpenHelix to Announce Free Tutorial and Training Materials 3Mutations directly identifiable in active genes 2Genedata Screener 8 Advancing Analysis of HCS, HTS and Time Series Data Debuts at SBS 16th Annual Conference 2Genedata Screener 8 Advancing Analysis of HCS, HTS and Time Series Data Debuts at SBS 16th Annual Conference 3Genedata Screener 8 Advancing Analysis of HCS, HTS and Time Series Data Debuts at SBS 16th Annual Conference 4
... Kits are designed for ultra-sensitive detection ... or PVDF membranes. Since all necessary ... primary antibodies), the WesternBreeze Kits save ... protocol and getting your final results. ...
Carbonate-Bicarbonate Buffer Capsules. For use in coating ELISA plates. Dissolve contents of 1 capsule in 100 ml deionized water to yield 0.05 M carbonate-bicarbonate buffer, pH 9.6....
... Adhesion Molecule The L1CAM ... involved in three distinct conditions: 1) HSAS ... MASA (mental retardation, aphasia, shuffling gait, adductus ... Immunogen: Homogenous suspension of ...
...
Biology Products: