Navigation Links
Eurofins' scientists discover genetic differences between 'identical' twins
Date:12/10/2013

Ebersberg, Germany, December 10, 2013 - Eurofins Scientific (EUFI.PA), a European leader in Genomics Services, Forensics and Paternity Testing, announces a milestone in genetic and forensic research. A multidisciplinary Eurofins team in the Eurofins flagship Genomics laboratory in Ebersberg, Germany, has successfully completed a research project to genetically discriminate "identical" monozygotic twins.

So far there have been only theoretical considerations against the experimental finding and dogma that monozygotic twins are genetically fully identical. Statistically, around 6 of 1,000 males are identical twins. Up to now, forensic DNA fingerprinting testing could not be used in crime or paternity cases involving identical twins, as there was no possibility of genetically discriminating between them. Such cases are regularly discussed in the World's press, including murder, child custody and heritage cases.

Forensic laboratories around the world had accepted these analytical restrictions, but Eurofins scientists wanted to push these limits of DNA testing. They used the unique combination of leading forensics and genomics labs available at Eurofins to reach this milestone.

Technically, the Eurofins scientists applied Eurofins' ultra-deep next generation sequencing and associated bioinformatics techniques. They sequenced DNA from sperm samples of two twins and from a blood sample of the child of one twin. Bioinformatics analysis revealed five mutations, so called Single Nucleotide Polymorphisms (SNPs) present in the twin father and the child, but not in the twin uncle. The SNPs were confirmed by classical Sanger sequencing. The results give experimental evidence for the hypothesis that rare mutations will occur early after or before the human blastocyst has split into two, the origin of twins, and that such mutations will be carried on into somatic tissue and the germ line.

The genetic differences found and the method used provide a solution to solve forensic and paternity cases involving monozygotic twins as originator of DNA traces in crime, or as alleged fathers. Eurofins is the first to offer such a test.

The peer-reviewed study "Finding the needle in the haystack: Differentiating "identical" twins in paternity testing and forensics by ultra-deep next generation sequencing" is published in the renowned journal Forensic Science International: Genetics, Available online 8 November 2013, ISSN 1872-4973, http://dx.doi.org/10.1016/j.fsigen.2013.10.015.

Bruno Poddevin, Senior Vice-President of the Genomic Services division and head of the Forensics laboratory at Eurofins, comments: "Eurofins scientists are the first to proof that monozygotic twins are genetically not absolutely identical. As the only provider worldwide Eurofins can now offer DNA forensic and paternity testing to discriminate identical twins to authorities, courts and individuals. Our leading genomic and forensic services team has provided the basis for reaching this milestone. As the first provider of next generation sequencing services in Europe, Eurofins also has proprietary, long expertise in the professional handling and analysis of the enormous amount of data involved in such a project. The dataset in this project equaled a total of 241 human genomes, resulting from up to 94 fold genomic coverage of the involved three individuals.


'/>"/>

Contact: Dr. Georg Gradl
georggradl@eurofins.com
49-809-282-89945
Eurofins MWG Operon
Source:Eurekalert

Related biology news :

1. Eurofins MWG Operon and Floragenex close co-marketing agreement for RAD discovery and RAD genotyping
2. Eurofins MWG Operon and Queen Mary, University Of London commence genome sequencing analysis of Ash
3. Eurofins MWG Operon reinforces NGS capability with Illumina HiSeq 2500 and Illumina MiSeq
4. Oregon scientists offer new insights on controlling nanoparticle stability
5. Argonne scientists Rajh, Soderholm and Segre named AAAS Fellows
6. Deep Carbon Observatory scientists discover quick recipe for producing hydrogen
7. Stanford scientists probe abandoned mine for clues about permanent CO2 sequestration
8. A*STAR scientists discover novel hormone essential for heart development
9. Scientists unearth secrets of Périgord truffles, the culinary black diamond
10. Top scientists to present at Epigenetic Control and Cellular Plasticity symposium
11. Salk scientists crack riddle of important drug target
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/20/2017)... , July 20, 2017 Delta (NYSE: DAL ... board any Delta aircraft at Reagan Washington National Airport (DCA). ... Delta launches biometrics to ... Delta,s biometric ... Sky Club is now integrated into the boarding process to allow ...
(Date:6/30/2017)... Today, American Trucking Associations announced Seeing ... and eye tracking software, became the newest member ... "Artificial intelligence and advanced sensing algorithms ... driver,s attentiveness levels while on the road.  Drivers ... fatigue and prevent potential accidents, which could lead ...
(Date:6/23/2017)... ITHACA, N.Y. , June 23, 2017 ... a leader in dairy research, today announced a new ... help reduce the chances that the global milk supply ... this dairy project, Cornell University has become the newest ... Food Supply Chain, a food safety initiative that includes ...
Breaking Biology News(10 mins):
(Date:7/24/2017)... Jersey (PRWEB) , ... July 24, 2017 , ... ... firms across the US and Canada who have proven their superior service quality ... Inavero identified Spearhead Staffing as an industry leader based on service quality ratings ...
(Date:7/24/2017)... ... July 24, 2017 , ... ... announced that the stock market news outlet had initiated coverage on Interpace ... that screens and identifies exposure, progression and risk analysis from specific cancers ...
(Date:7/20/2017)... Calif. (PRWEB) , ... July 20, 2017 , ... ... James G. Fujimoto, Ph.D ., the Elihu Thomson Professor of Electrical Engineering and ... Vision Research Award winner. Presented annually, the award recognizes an individual who ...
(Date:7/20/2017)... ... July 20, 2017 , ... Resoundant, Inc. ... and imaging centers around the U.S. that offer MR Elastography for liver fibrosis ... to needle biopsy for staging liver fibrosis assessment. , “MRE:connect was created in ...
Breaking Biology Technology: