Navigation Links
Eurofins' scientists discover genetic differences between 'identical' twins
Date:12/10/2013

Ebersberg, Germany, December 10, 2013 - Eurofins Scientific (EUFI.PA), a European leader in Genomics Services, Forensics and Paternity Testing, announces a milestone in genetic and forensic research. A multidisciplinary Eurofins team in the Eurofins flagship Genomics laboratory in Ebersberg, Germany, has successfully completed a research project to genetically discriminate "identical" monozygotic twins.

So far there have been only theoretical considerations against the experimental finding and dogma that monozygotic twins are genetically fully identical. Statistically, around 6 of 1,000 males are identical twins. Up to now, forensic DNA fingerprinting testing could not be used in crime or paternity cases involving identical twins, as there was no possibility of genetically discriminating between them. Such cases are regularly discussed in the World's press, including murder, child custody and heritage cases.

Forensic laboratories around the world had accepted these analytical restrictions, but Eurofins scientists wanted to push these limits of DNA testing. They used the unique combination of leading forensics and genomics labs available at Eurofins to reach this milestone.

Technically, the Eurofins scientists applied Eurofins' ultra-deep next generation sequencing and associated bioinformatics techniques. They sequenced DNA from sperm samples of two twins and from a blood sample of the child of one twin. Bioinformatics analysis revealed five mutations, so called Single Nucleotide Polymorphisms (SNPs) present in the twin father and the child, but not in the twin uncle. The SNPs were confirmed by classical Sanger sequencing. The results give experimental evidence for the hypothesis that rare mutations will occur early after or before the human blastocyst has split into two, the origin of twins, and that such mutations will be carried on into somatic tissue and the germ line.

The genetic differences found and the method used provide a solution to solve forensic and paternity cases involving monozygotic twins as originator of DNA traces in crime, or as alleged fathers. Eurofins is the first to offer such a test.

The peer-reviewed study "Finding the needle in the haystack: Differentiating "identical" twins in paternity testing and forensics by ultra-deep next generation sequencing" is published in the renowned journal Forensic Science International: Genetics, Available online 8 November 2013, ISSN 1872-4973, http://dx.doi.org/10.1016/j.fsigen.2013.10.015.

Bruno Poddevin, Senior Vice-President of the Genomic Services division and head of the Forensics laboratory at Eurofins, comments: "Eurofins scientists are the first to proof that monozygotic twins are genetically not absolutely identical. As the only provider worldwide Eurofins can now offer DNA forensic and paternity testing to discriminate identical twins to authorities, courts and individuals. Our leading genomic and forensic services team has provided the basis for reaching this milestone. As the first provider of next generation sequencing services in Europe, Eurofins also has proprietary, long expertise in the professional handling and analysis of the enormous amount of data involved in such a project. The dataset in this project equaled a total of 241 human genomes, resulting from up to 94 fold genomic coverage of the involved three individuals.


'/>"/>

Contact: Dr. Georg Gradl
georggradl@eurofins.com
49-809-282-89945
Eurofins MWG Operon
Source:Eurekalert

Related biology news :

1. Eurofins MWG Operon and Floragenex close co-marketing agreement for RAD discovery and RAD genotyping
2. Eurofins MWG Operon and Queen Mary, University Of London commence genome sequencing analysis of Ash
3. Eurofins MWG Operon reinforces NGS capability with Illumina HiSeq 2500 and Illumina MiSeq
4. Oregon scientists offer new insights on controlling nanoparticle stability
5. Argonne scientists Rajh, Soderholm and Segre named AAAS Fellows
6. Deep Carbon Observatory scientists discover quick recipe for producing hydrogen
7. Stanford scientists probe abandoned mine for clues about permanent CO2 sequestration
8. A*STAR scientists discover novel hormone essential for heart development
9. Scientists unearth secrets of Périgord truffles, the culinary black diamond
10. Top scientists to present at Epigenetic Control and Cellular Plasticity symposium
11. Salk scientists crack riddle of important drug target
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/7/2016)... -- Syngrafii Inc. and San Antonio Credit Union (SACU) ... Syngrafii,s patented LongPen™ eSignature "Wet" solution into SACU,s ... in greater convenience for SACU members and operational ... document workflow and compliance requirements. Logo ... Highlights: ...
(Date:6/2/2016)... LONDON , June 2, 2016 ... has awarded the 44 million US Dollar project, ... Security Embossed Vehicle Plates including Personalization, Enrolment, and IT Infrastructure ... world leader in the production and implementation of Identity Management ... in January, however Decatur was selected ...
(Date:6/2/2016)... , June 2, 2016 Perimeter ... Platforms, Unmanned Systems, Physical Infrastructure, Support & Other Service  ... visiongain offers comprehensive analysis of the global ... market will generate revenues of $17.98 billion in 2016. ... DVTEL Inc, a leader in software and hardware technologies ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 2016 On Wednesday, June 22, 2016, ... 0.22%; the Dow Jones Industrial Average edged 0.27% lower to ... down 0.17%. Stock-Callers.com has initiated coverage on the following equities: ... (NASDAQ: NKTR ), Aralez Pharmaceuticals Inc. (NASDAQ: ... BIND ). Learn more about these stocks by accessing their ...
(Date:6/23/2016)... 23, 2016 ReportsnReports.com adds ... to its pharmaceuticals section with historic and forecast ... much more. Complete report on the ... profiling 15 companies and supported with 261 tables ... . The Global Cell Culture ...
(Date:6/22/2016)... ... June 22, 2016 , ... Quantitative Radiology Solutions, the ... current participant in the Phase 1 Ventures program, is leveraging regional and federal ... Radiology Solutions helps physicians make better treatment decisions by quantifying medical imaging using ...
(Date:6/22/2016)... Fla. and ALBANY, N.Y. ... Sciences Corporation (Teewinot) and Albany Molecular Research, Inc. ... AMRI has licensed Teewinot,s technology to produce and ... analytical standard. The CBCA analytical standard is manufactured ... involve the expression of cannabinoid biosynthetic genes in ...
Breaking Biology Technology: