Navigation Links
Estrogen hormone reveals protective ability after traumatic brain injury
Date:4/22/2012

SAN DIEGO With more than 1.7 million people sustaining a traumatic brain injury each year, the need to identify processes to limit inflammation and subsequent damage is critical. Approximately 275,000 people are hospitalized annually with traumatic brain injury, leaving 85,000 with long-term disabilities and taking the lives of more than 50,000. More than 5 million people live with disabilities caused by traumatic brain injuries, often the result of car accidents and falls. Direct and indirect costs exceed $75 billion.

Dr. Joshua Gatson, Assistant Professor of Surgery at the University of Texas Southwestern Medical Center in Dallas, investigates biomarkers and novel therapies for traumatic brain injury. His previous work has shown that estrone, one of the three naturally occurring estrogen hormones in the body, has shown some promise in reducing inflammation and cell death in the brain. His latest study is the first to demonstrate estrone provides those anti-inflammatory and antioxidant capabilities after traumatic brain injury. It is likewise the first to reveal the cellular pathways that are involved. His findings will be presented April 22, 2012 during Experimental Biology 2012 in San Diego, CA.

The study, conducted in male rats, compared 0.5 mg of estrone to a placebo, both given 30 minutes after the injury. It demonstrated that estrone is involved in promoting brain-derived neurotrophic factor (BDNF), which promotes cell survival. "BDNF, one of the main growth factors that regulates repair following injury, is actually increased following treatment with estrone after brain injury," said Gatson, who administered the injections within 30 minutes of the injury. "So if you give this drug shortly after injury, it is thought to increase repair mechanisms."

Most research involving protective capabilities of estrogen have focused instead on estradiol, one of the other two types of estrogen hormones, Dr. Gatson noted, so this finding indicates a fresh avenue for future study.


'/>"/>

Contact: Suzanne Price
sprice@nutrition.org
619-525-6213
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. New estrogen receptor found to be key player in tamoxifen resistance
2. Estrogen-dependent switch tempers killing activity of immune cells
3. Supplement blocks the initiation of breast cell mutations by estrogens
4. Gallbladder cancer may be linked to estrogens, says UH team
5. UC research: Rabbits food brings luck in decreasing estrogen levels in wastewater
6. PET scans reveal estrogen-producing hotspots in human brain
7. Infant estrogen levels tracked through diaper research
8. New report: Dont blame the pill for estrogen in drinking water
9. Estrogen alone is effective for reducing breast cancer risk
10. Estrogen may help precancerous cells spread in oral cavity
11. UT researchers link algae to harmful estrogen-like compound in water
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/23/2017)... help is being enlisted in what,s thought to be the biggest study ... body –and are believed to affect health.  ... The Microbiome Immunity Project is the largest study to date of ... goal is to help advance scientific knowledge of the role of these ... The Microbiome ...
(Date:6/30/2017)... June 30, 2017 Today, American Trucking ... supplier of face and eye tracking software, became ... provider program. "Artificial intelligence and ... to monitor a driver,s attentiveness levels while on ... able to detect fatigue and prevent potential accidents, ...
(Date:5/23/2017)... Italy , May 23, 2017  Hunova, the first robotic gym ... trunk, has been officially launched in Genoa, Italy . ... Europe and the USA . The technology ... on the market by the IIT spin-off Movendo Technology thanks to a ... the Multimedia News Release, please click: ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... 2017 , ... Personal eye wash is a basic first aid supply for any work environment, ... eye do you rinse first if a dangerous substance enters both eyes? It’s one less ... with its unique dual eye piece. , “Whether its dirt and debris, or an acid ...
(Date:10/11/2017)... ... ... Disappearing forests and increased emissions are the main causes of the evolving ... those living in larger cities are affected by air pollution related diseases. , That ... countries globally - decided to take action. , “I knew I had to take ...
(Date:10/10/2017)... ... October 10, 2017 , ... For the second time in ... STEM Mentoring Award. Representatives of the FirstHand program travelled to Washington, D.C. Tuesday, ... , US2020’s mission is to change the trajectory of STEM education in America ...
(Date:10/10/2017)... ... 2017 , ... The Pittcon Program Committee is pleased to ... who have made outstanding contributions to analytical chemistry and applied spectroscopy. Each award ... conference and exposition for laboratory science, which will be held February 26-March 1, ...
Breaking Biology Technology: