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Essential protein for the formation of new blood vessels identified
Date:1/17/2012

uld not migrate in a group."

The meaning of this discovery became clear in further experiments: the role of Raf-1 is to bring the new adherens junctions a kinase they need for the remodeling of the cytoskeleton. This means that Raf-1 is fine-tuning the bonds between the migrating cells by causing the local remodeling of the cell's cytoskeleton.

As the process of angiogenic sprouting is necessary for the growth of tumors, this new discovery may one day be applied to produce cancer therapies to target Raf-1 and the other parts of this control mechanism, thereby disrupting the environment of the tumor.


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Contact: Reiner Wimmer
reiner.wimmer@univie.ac.at
University of Vienna
Source:Eurekalert  

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