Navigation Links
Essential protein for the formation of new blood vessels identified
Date:1/17/2012

This release is available in German.

New research explains how cells regulate their bonds during the development of new blood vessels. For the first time, the role of the protein Raf-1 in determining the strength of the bond between cells has been shown. Manuela Baccarini's group at the Max F. Perutz Laboratories, a joint venture of the University of Vienna and the Medical University of Vienna, shows if Raf-1 is not present, the cells cannot stick together and the formation of new blood vessels is inhibited. This discovery may one day lead to new approaches to cancer treatment.

Angiogenic sprouting, the process by which new blood vessels grow from existing vessels, is a double-edged sword. It enables the cardiovascular system to develop in the embryo, and is vital for tissue regeneration in adults. But it also supplies growing tumors with nutrients and oxygen.

Angiogenesis is an example of collective cellular migration. Cells move as a group, held together by connections called adherens junctions. For the cells to move, they have to make and break these connections continuously. If the junctions are too stiff, they will not be able to move at all, but if they are too weak, the groups of cells will break apart. How this mechanism is controlled was unknown.

The mechanism has now been uncovered by Manuela Baccarini's group at the Max F. Perutz Laboratories, a joint venture of the University of Vienna and the Medical University of Vienna, who investigate cell signaling. They have established a crucial role for Raf-1, a multi-purpose signal transducer, in this process.

"The real breakthrough came when we were able to use video microscopy on the developing vessels in vitro," explains the paper's first author Reiner Wimmer. "We realized that the cells without Raf-1 were actively migrating, but only as single cells. They could not migrate in a group."

The meaning of this discovery became clear in further experiments: the role of Raf-1 is to bring the new adherens junctions a kinase they need for the remodeling of the cytoskeleton. This means that Raf-1 is fine-tuning the bonds between the migrating cells by causing the local remodeling of the cell's cytoskeleton.

As the process of angiogenic sprouting is necessary for the growth of tumors, this new discovery may one day be applied to produce cancer therapies to target Raf-1 and the other parts of this control mechanism, thereby disrupting the environment of the tumor.


'/>"/>

Contact: Reiner Wimmer
reiner.wimmer@univie.ac.at
University of Vienna
Source:Eurekalert  

Related biology news :

1. Researchers find an essential gene for forming ears of corn
2. Rethinking who should be considered essential during a pandemic flu outbreak
3. New lab manual focuses on essential methods for purifying and characterizing proteins
4. New edition available for essential virology reference
5. New guide to tropical seedlings: Essential to climate change research
6. Mystery E. coli genes essential for survival of many species
7. Essential nutrient found in eggs may help lower risk of neural tube defects
8. Loss of tumor supressor gene essential to transforming benign nerve tumors into cancers
9. New research examining essential drugs, emerging botanicals supported by USP Awards
10. Researchers pin down long-elusive protein thats essential to life as we know it
11. Registered dietitians play essential role in management of gastric bypass patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Essential protein for the formation of new blood vessels identified
(Date:4/11/2017)... , April 11, 2017 NXT-ID, ... security technology company, announces the appointment of independent Directors Mr. ... to its Board of Directors, furthering the company,s corporate ... ... NXT-ID, we look forward to their guidance and benefiting from ...
(Date:4/4/2017)... --  EyeLock LLC , a leader of iris-based identity ... and Trademark Office (USPTO) has issued U.S. Patent No. ... iris image with a face image acquired in sequence ... th issued patent. "The issuance ... multi-modal biometric capabilities that have recently come to market ...
(Date:3/29/2017)... -- higi, the health IT company that operates the largest ... , today announced a Series B investment from BlueCross ... new investment and acquisition accelerates higi,s strategy to create ... health activities through the collection and workflow integration of ... and secures data today on behalf of over 36 ...
Breaking Biology News(10 mins):
(Date:4/19/2017)... SOUTH SAN FRANCISCO, Calif. , April 19, ... VCYT ) today announced that it ... after close of market on Wednesday, May 3, 2017. ... call and webcast at 4:30 p.m. Eastern Time to discuss ... The live webcast and subsequent replay may ...
(Date:4/18/2017)... ... April 18, 2017 , ... METTLER TOLEDO Process ... concentration levels and vice-versa. , One of the key applications for the measurement ... control or monitoring. The principle of this analytical method is based on pure ...
(Date:4/18/2017)... ... April 18, 2017 , ... For a historic seventh consecutive ... the VaxCorps vaccine consortium, were named one of the top two Clinical Research Sites ... of this category; winning the award four times previously, and first runner up the ...
(Date:4/18/2017)... ... April 18, 2017 , ... Cancer ... Boguski has been appointed to the role of Chief Medical Officer (CMO) – ... , “Dr. Boguski is widely considered a visionary leader in precision medicine, and ...
Breaking Biology Technology: