Navigation Links
Esophageal cancer risk lower than expected for patients with GERD
Date:12/9/2010

ANN ARBOR, Mich. The risk of esophageal cancer among patients who suffer from gastroesophageal reflux disease (GERD) is not as high as many may think, according to new research from University of Michigan gastroenterologists.

GERD is considered a relative risk for developing esophageal adenocarcinoma, but the absolute risk is not known, says Joel Rubenstein, M.D., M.Sc., an investigator with the Department of Veterans Affairs Center for Clinical Management Research in Ann Arbor and Assistant Professor in the University of Michigan's Department of Internal Medicine.

"Since GERD is incredibly common, many people may be worried about their increased risk for developing cancer due to GERD. This study's results help put that risk into perspective and may help physicians decide when screening to prevent cancer is needed," says Rubenstein.

Rubenstein and his co-authors set out to estimate the incidence of new cases of esophageal adenocarcinoma in the large population of people with GERD symptoms.

The research published in the American Journal of Gastroenterology this week found:

  • Women with GERD likely have a low rate of esophageal adenocarcinoma, similar to the rate of breast cancer in men.
  • The rate of esophageal adenocarcinoma in white men who are 60 years old with weekly GERD is just one-third of their rate of colorectal cancer or 34.6 per 100,000 patients per year.
  • The rate of esophageal adenocarcinoma in younger white men with GERD is less than one-third of their incidence of colorectal cancer.

GERD is characterized by symptoms that result from repeated or prolonged exposure of the lining of the esophagus to acidic contents from the stomach and occurs when the lower esophageal sphincter does not seal off the esophagus from the stomach.

The two most frequently reported symptoms of GERD are heartburn and regurgitation, which is characterized by the effortless flow of fluid rising up the chest toward the mouth. Some estimates say up to 1 in 4 people in U.S. suffer from GERD.

Rubenstein concluded that screening for esophageal adenocarcinoma should not be performed in men younger than age 50 or in women because of the very low incidences of the cancer, regardless of the frequency of GERD symptoms. However, in white men with weekly GERD over the age of 60, the incidence of esophageal adenocarcinoma is substantial and may warrant screening.

"Our study does not say who should be screened or the effectiveness of the screening. But we can say that for a 60-year-old man with GERD, screening for colon cancer is more important than screening for esophageal adenocarcinoma," Rubenstein says.

"We hope this study can help physicians recognize the absolute risk of esophageal adenocarcinoma in patients with GERD within the context of the risk of more familiar cancers, and make it easier to communicate these risks to patients, guiding them in rational decisions about screening procedures."

He cautioned however, that if patients are experiencing alarm symptoms such as trouble swallowing, unintentional weight loss, or vomiting, they should seek medical care immediately, as these symptoms could be due to a cancer already present in the esophagus.


'/>"/>

Contact: Mary F. Masson
mfmasson@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Related biology news :

1. University of Saskatchewan and Canadian Synchrotron researchers shed light on esophageal disease
2. Genetic predictors of esophageal cancer identified
3. H. Pylori bacteria may help prevent some esophageal cancers
4. Estrogen alone is effective for reducing breast cancer risk
5. George W. Sledge, Jr., M.D., honored for international contributions to breast cancer research
6. VCU Massey discovery could lead to breakthrough for non-small cell lung cancer
7. SomaLogic researchers describe revolutionary new approach to protein analysis and application to early diagnosis of lung cancer
8. MU cancer scientists form new company with international pharmaceutical firm
9. Scientists propose new international cancer effort akin to Human Genome Project
10. U of I scientists develop tool to trace metabolism of cancer-fighting tomato compounds
11. New strategies for cancer drug development urgently needed
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2017)... May 16, 2017  Veratad Technologies, LLC ( www.veratad.com ... age and identity verification solutions, announced today they will ... 2017, May 15 thru May 17, 2017, in ... International Trade Center. Identity impacts the ... in today,s quickly evolving digital world, defining identity is ...
(Date:5/6/2017)... SINGAPORE , May 5, 2017 ... has just announced a new breakthrough in biometric ... that exploits quantum mechanical properties to perform ... new smart semiconductor material created by Ram Group ... across finance, entertainment, transportation, supply chains and security. ...
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
Breaking Biology News(10 mins):
(Date:9/17/2017)... ... 17, 2017 , ... GeneOne Life Science, Inc. announces that ... Safety (KMFDS) for an Investigational New Drug application for a Phase I/IIa study ... The study in Korea represents the second clinical trial for GLS-5300. , ...
(Date:9/14/2017)... ... September 14, 2017 , ... DrugDev ... biotech at the third annual DrugDev Summit, November 7-8, 2017 in Philadelphia, PA. ... most progressive clinical research leaders for best practice case studies, keynote presentations, lively ...
(Date:9/14/2017)... ... September 14, 2017 , ... AxioMed is pleased to ... Dr. Steven Yang completed the procedure on a 35-year-old female patient suffering from ... disc at level L5-S1. The patient failed conservative treatments prior to undergoing surgery. ...
(Date:9/14/2017)... ... September 14, 2017 , ... Cambridge Semantics , the ... that its Anzo Smart Data Lake has been named a KMWorld Trend-Setting ... that help organizations succeed in surpassing their knowledge management goals. KMWorld searches for ...
Breaking Biology Technology: