Navigation Links
Eribulin mesylate demonstrated anti-tumor activity in patients with advanced breast cancer
Date:5/30/2008

ine patients met the key inclusion criteria. In patients who received a median of four cycles of eribulin mesylate, Overall Response Rate (ORR) by Independent Review (IR) was 9.3% (all Partial Responses (PR); 95% confidence interval [CI]: 6.1%-13.4%). Investigator-assessed ORR was 14.1% (1 CR; 95% CI: 10.2%-18.9%). Nearly half (46.5%) the patients had stable disease (SD) after treatment with eribulin mesylate. The clinical benefit rate (CBR, defined as CR+PR+SD 6 months) was 17.1% (95% CI: 12.8%-22.1%).

The median duration of response was 4.2 months (126 days, range: 42 -258 days; 95% CI: 86-147). Median progression-free survival (PFS) was 2.6 months (79 days, range: 1*-397 days), and the median overall survival (OS) rate was 10.3 months (315 days, range: 19-604 days; 95% CI: 279-350). The six-month PFS and OS rates were 16.0% (95% CI: 8.6-17.0) and 72.3%, respectively (95% CI: 66.9-77.6).

The safety analysis included all 291 patients who received treatment with eribulin mesylate. Patients with up to Grade 2 peripheral neuropathy were included in the study. The most frequently reported Grade 3 (severe) or Grade 4 (disabling or life- threatening) adverse events were neutropenia (a decrease in the number of granular white blood cells, 54%); febrile neutropenia, 5.5%, leukopenia (low white blood cell count, 14%), and weakness/fatigue (10%; no Grade 4 events). Grade 3 peripheral neuropathy (a functional disturbance or damage to nerves outside the brain and spinal cord) was reported in 5.5% of patients. No Grade 4 peripheral neuropathy events were reported. No correlation was seen between Grade 2 peripheral neuropathy and deterioration.

"In this study, eribulin mesylate appeared to have an acceptable tolerability profile, particularly with regard to the low incidence of peripheral neuropathy," noted Vahdat. "None of the reported cases of neuropathy were disabling, suggesting that eribulin mesylate, if approved, may be a useful addit
'/>"/>

Contact: Judee Shuler
201-746-2241
Eisai Inc.
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UM coral scientist Peter Glynn wins award for scholarly activity
2. Blood pressure drug telmisartan shows powerful activity against stroke
3. Cold Spring Harbor Protocols highlights a method that captures cell growth and activity
4. CAPHOSOL relieves oral mucositis and improves quality-of-life in cancer patients
5. Cell-based therapy shows promise in patients with Parkinsons disease
6. Scientists test device to track medication adherence in patients with HIV/AIDS
7. Three Dimensional Visualization of Right Ventricle Provides Important Information for Treatment of Patients with Tetralogy of Fallot, According to a Study in The American Journal of Cardiology
8. New chemotherapy combo produces side effects, but no extra efficacy, in early breast cancer patients
9. Pregnant patients lose out in breast cancer treatment; a new approach is needed
10. Mental stress reduces blood flow to the heart in patients with gene variation
11. 2 new therapies show promise for cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2014)... Miami could know as early as 2020 how high ... to a team of researchers including Florida International University ... the National Science Foundation,s (NSF) Florida Coastal Everglades Long-Term ... LTER sites in ecosystems from coral reefs to deserts, ... conclude that sea level rise is one of the ...
(Date:4/15/2014)... UC San Diego have succeeded in visualizing the ... for growth and resistance to drought. The achievement ... determine how the hormone helps plants respond to ... continuing increase in the atmosphere,s carbon dioxide, or ... in the April 15 issue of the scientific ...
(Date:4/15/2014)... found a less invasive way to extract single ... how the mouth,s natural defenses ward off infection ... cells (white blood cells known as "leukocytes") to ... reject foreign tissues, such as in failed organ ... preventing such health issues as oral cancers, cardiovascular ...
Breaking Biology News(10 mins):Long-term predictions for Miami sea level rise could be available relatively soon 2Biologists develop nanosensors to visualize movements and distribution of plant hormone 2New method isolates immune cells for researchers to study how they ward off oral diseases 2
... Foundation announced that it will provide $200,000 in 2009 to ... treatment for Rett Syndrome. The study will be carried ... Boston Children,s Hospital, led by Dr. Omar Khwaja MD, PhD ... to be tested in Rett syndrome patients. Investigators will ...
... 2009 CryoLife, Inc. (NYSE: CRY) Elite cardiovascular surgeons ... week for the two-day Ross Summit to review and discuss ... Ross Procedure and to practice the technical nuances required to ... is a type of specialized aortic valve surgery in which ...
... 21, 2009 -- Investigators at Burnham Institute for ... for the enzyme caspase-3 (an enzyme that proteolytically ... called N-terminomics, Guy Salvesen, Ph.D., professor and director ... of Burnham,s NCI-designated Cancer Center, and colleagues determined ...
Cached Biology News:IRSF announces funding of first clinical trial with disease-modifying therapy for Rett syndrome 2Growing outcomes evidence spurs renewed interest in unique heart valve procedure 2How proteins talk to each other 2
(Date:1/15/2014)... 2014 The Microcompetition with Foreign DNA ... disease. One of these latent viruses is the Epstein ... rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a chronic ... by the theory, a study found that RA patients ... (1). , What is Microcompetition? , Dr. Hanan ...
(Date:1/15/2014)... Sunnyvale, CA (PRWEB) January 15, 2014 ... of high throughput research solutions, today announced that ... companies, has received delivery of Freeslate’s CM ... form screening. , Lupin, headquartered in Mumbai, ... quality, affordable generic and branded formulations and Active ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 Date: Friday, ... p.m. , Location: Warrington Country Club, 1360 Almshouse Road, ... Foundation, the only national nonprofit organization solely dedicated to ... quality of life for those affected worldwide, will host ... Warrington Country Club in Warrington, Pa. , Each ...
(Date:1/14/2014)... , Jan. 14, 2014  3D Communications, a leading provider ... major scientific, regulatory, business, and media events in ... , today announced its former associate Virginia Cox , ... office. Virginia Cox re-joins ... Commissioner for the Office of External Affairs at the U.S. ...
Breaking Biology Technology:Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2Former FDA Associate Commissioner Returns To 3D Communications 2
... Standard Networks announced Tuesday a new platform-independent Java ... MOVEit DMZ servers over firewall-friendly HTTPS encrypted connections. , ... for specific platforms, including a Windows API and a ... and secure FTP access. , ,The Java offering is ...
... the Midwest Tel Net consortium have selected Occam ... and high-speed data to the companies' rural residential and ... are Hillsboro Telephone Co. Inc., LaValle Telephone Cooperative and ... was the first local carrier in Wisconsin to ...
... University's new "living laboratory" of teaching technology will ... Madison-based Sonic Foundry, Inc. , to automatically ... company announced Monday. , ,The laboratory, termed the ... with data for making informed investment decisions across ...
Cached Biology Technology:Three Midwest Tel Net members select Occam's platform to increase service 2Ohio State's educational tech lab to use Sonic Foundry system 2
Sheep polyclonal to Salmonella Shoreditch ( Abpromise for all tested applications). Antigen: Native Salmonella shoreditch (Group D2)....
Rabbit polyclonal to ZA20D3 ( Abpromise for all tested applications). entrezGeneID: 54469 SwissProtID: Q6FIF0...
... Rabbit polyclonal to Oct6 ( Abpromise ... Synthetic peptide conjugated to KLH derived from ... (Note: the amino acid sequence is proprietary) ... .) Entrez Gene ID: ...
ATP-binding cassette sub-family D member 4 (Peroxisomal membrane protein 69) (PMP69) (Peroxisomal membrane protein 1-like) (PXMP1-L) (P70R). [Source:Uniprot/SWISSPROT;Acc:O14678] Antigen: Recombi...
Biology Products: