Navigation Links
Erg gene key to blood stem cell 'self-renewal'
Date:2/16/2011

r function of adult blood stem cells. They decided to look at blood stem cells in a developing embryo, a time when the cells are particularly active, to determine ERG's role in stem cell production and maintenance.

"We found that during development, ERG was not needed for the original blood stem cells to be made, or to produce mature blood cells," Dr Taoudi said. "But without ERG, these new blood stem cells rapidly decreased as they divided to produce more blood, so that they were almost completely exhausted by the time the mouse was born."

Further testing revealed that two other genes important in embryonic development, GATA2 and RUNX1, were controlled by ERG at the blood producing stage of development.

"These genes are called transcription factors, they are the 'switches' that turn on and off other genes," Dr Taoudi said. "Individually, these genes are not essential for regeneration, but if you lose both, the stem cells are quickly exhausted. This is a key part of the puzzle, but we will continue to work to find out how these genes directly control self-renewal, and the signals that actually tell the stem cell to regenerate."

Dr Taoudi said that although the finding had promise for the future therapeutic use of blood stem cells, there was still a lot of work to be done.

"We have found part of the pathway required for the expansion of blood stem cells under normal conditions, but from a translation perspective, we still need to establish whether increasing expression of these genes will actually lead to expansion in a culture dish," he said.


'/>"/>

Contact: Penny Fannin
fannin@wehi.edu.au
61-393-452-345
Walter and Eliza Hall Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Blood-clotting protein linked to cancer and septicemia
2. Conversion of brain tumor cells into blood vessels thwarts treatment efforts
3. Red blood cell hormone modulates the immune system
4. Common antibiotics and blood pressure medication may result in hospitalization
5. Blood pressure control system found in kidneys structural units
6. New method will triple amount of genetic information from newborn blood spot screenings
7. Biomedical breakthrough: Blood vessels for lab-grown tissues
8. Researchers investigate why a limited number of white blood cells are attracted to injured tissue
9. UTHealth studies cord blood stem cells for pediatric traumatic brain injury
10. High red blood cell folate levels linked to silenced tumor-suppressors
11. Cord blood cell transplantation provides improvement for severely brain-injured child
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Erg gene key to blood stem cell 'self-renewal'
(Date:1/22/2015)... Jan. 16, 2015  A man-made form of insulin delivered ... mental capabilities in adults with mild cognitive impairment and ... by researchers at Wake Forest Baptist Medical Center. ... amnesic mild cognitive impairment (MCI) or mild to moderate ...
(Date:1/22/2015)... Jan. 21, 2015  Analyst Report Issued by Small Cap IR. ... showed that planet-wide, transactions at merchants on the leading payment ... number of credit, debit, and prepaid cards reached 6.54 billion.  ... of fraudulent card usage in 2012, and credit and debit ...
(Date:1/22/2015)... EyeLock, Inc. , a market leader of iris-based identity authentication ... to the new role of Senior Vice President of Mobile ... mobile platforms and wearable solutions for EyeLock,s technologies. Gerber brings ... semiconductor industry to his role at EyeLock, with expertise in ...
Breaking Biology News(10 mins):Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 3$4.80 Near Term Price Target with "Buy" given by CapRock Research for NXT-ID, Inc. (NASDAQ: NXTD) issued by Small Cap IR 2EyeLock Names Steve Gerber as Senior Vice President of Mobile and Wearables 2
... scientists has analyzed 29 esparto fields from Guadalajara to ... an efficient early warning system against desertification in these ... Ecology magazine. In order to ... United Nations as the "degradation of the land into ...
... available in German . , Berlin, 2 ... Earth,s multi-trillion dollar ecosystems - from forests and mangroves to ... in countering climate change and climate-proofing vulnerable economies. This ... update by The Economics of Ecosystems and Biodiversity (TEEB), a ...
... The Cold Facts about Melting Glaciers ... response to a warming climate. During the past 50 years, ... thickness) of three glaciers: Alaska,s Gulkana and Wolverine Glaciers and ... in North America and among the longest in the world. ...
Cached Biology News:Perennial vegetation, an indicator of desertification in Spain 2Perennial vegetation, an indicator of desertification in Spain 3Time to tap climate change-combating potential of the world's ecosystems 2Time to tap climate change-combating potential of the world's ecosystems 3Time to tap climate change-combating potential of the world's ecosystems 4Time to tap climate change-combating potential of the world's ecosystems 5USGS science picks 2USGS science picks 3USGS science picks 4USGS science picks 5USGS science picks 6USGS science picks 7USGS science picks 8USGS science picks 9
(Date:1/22/2015)... Dr. Greg Leyer of UAS Labs recently ... Supplements Pre-Conference seminar on probiotics in San Diego, CA. ... education conference for health care professionals. This year’s pre-conference seminar ... probiotics in health. Dr. Leyer spoke about the emerging topics ...
(Date:1/22/2015)... 22, 2015   Cypher Genomics, Inc., the ... SQNM ), the leading molecular diagnostics ... generation noninvasive prenatal tests (NIPT). Through this agreement, ... Mantis™, to advance analysis of clinically-relevant fetal sub-chromosomal ...
(Date:12/24/2014)...  United Therapeutics Corporation (NASDAQ: UTHR ) announced ... has submitted a pre-market approval application to the U.S. ... Medtronic,s SynchroMed ® II implantable drug infusion system ... Therapeutics, Remodulin ® (treprostinil) Injection delivered intravenously to ...
(Date:12/24/2014)... GMO corn cases filed across the United ... process of being consolidated in a Kansas federal court for ... MIR 162 Corn Litigation, MDL No. 2591 in the U.S. ... the Syngenta GMO corn multidistrict litigation (MDL) has been handed ...
Breaking Biology Technology:Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2
... , ,My youngest brother once took a job selling encyclopedias ... about making a daily quota, cooking communal dinners and sleeping ... weeks of this, my brother caught a ride back to ... environmentally friendly household products, which he first had to buy ...
... API Software announced on Monday that for ... top time and attendance application in the KLAS ... rankings API received the highest possible distinction in customer satisfaction, ... in terms of detail and business indicators and demonstrating an ...
... invest $125,000 to help create a technology transfer project ... on Monday. , ,The Racine County Economic Development ... and Innovation will organize the project, which will ... analog is the Wisconsin Alumni Research Foundation, which handles ...
Cached Biology Technology:Beware the cold-call job interview 2Beware the cold-call job interview 3Beware the cold-call job interview 4Beware the cold-call job interview 5API Software best in health-care customer satisfaction, says KLAS report 2
Rabbit polyclonal to Phosphothreonine-X-Phosphotyrosine (HRP) ( Abpromise for all tested applications)....
PE Rat anti-Hu CD267 Storage Temperature: Refrigerate(2 to 8C)...
WD-repeat protein 4...
... Cultured human omental ... obese but otherwise healthy ... availability of diabetic cells. ... information. Support media also ...
Biology Products: