Navigation Links
Erg gene key to blood stem cell 'self-renewal'
Date:2/16/2011

r function of adult blood stem cells. They decided to look at blood stem cells in a developing embryo, a time when the cells are particularly active, to determine ERG's role in stem cell production and maintenance.

"We found that during development, ERG was not needed for the original blood stem cells to be made, or to produce mature blood cells," Dr Taoudi said. "But without ERG, these new blood stem cells rapidly decreased as they divided to produce more blood, so that they were almost completely exhausted by the time the mouse was born."

Further testing revealed that two other genes important in embryonic development, GATA2 and RUNX1, were controlled by ERG at the blood producing stage of development.

"These genes are called transcription factors, they are the 'switches' that turn on and off other genes," Dr Taoudi said. "Individually, these genes are not essential for regeneration, but if you lose both, the stem cells are quickly exhausted. This is a key part of the puzzle, but we will continue to work to find out how these genes directly control self-renewal, and the signals that actually tell the stem cell to regenerate."

Dr Taoudi said that although the finding had promise for the future therapeutic use of blood stem cells, there was still a lot of work to be done.

"We have found part of the pathway required for the expansion of blood stem cells under normal conditions, but from a translation perspective, we still need to establish whether increasing expression of these genes will actually lead to expansion in a culture dish," he said.


'/>"/>

Contact: Penny Fannin
fannin@wehi.edu.au
61-393-452-345
Walter and Eliza Hall Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Blood-clotting protein linked to cancer and septicemia
2. Conversion of brain tumor cells into blood vessels thwarts treatment efforts
3. Red blood cell hormone modulates the immune system
4. Common antibiotics and blood pressure medication may result in hospitalization
5. Blood pressure control system found in kidneys structural units
6. New method will triple amount of genetic information from newborn blood spot screenings
7. Biomedical breakthrough: Blood vessels for lab-grown tissues
8. Researchers investigate why a limited number of white blood cells are attracted to injured tissue
9. UTHealth studies cord blood stem cells for pediatric traumatic brain injury
10. High red blood cell folate levels linked to silenced tumor-suppressors
11. Cord blood cell transplantation provides improvement for severely brain-injured child
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Erg gene key to blood stem cell 'self-renewal'
(Date:9/30/2014)... have in common? Unlike most eukaryotic multicellular organisms ... these organisms are all polyploid, meaning they have three ... 3 and 4 sets of chromosomes, respectively, and strawberries ... fact most plant species are polyploid. Polyploidy, or genome ... only recently, with the development of molecular tools, has ...
(Date:9/30/2014)... Ecker, a Salk professor and Howard Hughes Medical ... have been named recipients in the 2014 round ... (NIH) through the BRAIN (Brain Research through Advancing ... The grant, announced September 30, provides more than ... over three years. , The BRAIN Initiative, launched ...
(Date:9/30/2014)... of Medicine reports positive results of a phase ... subset of lung cancer marked by rearrangement of the ... with advanced non-small cell lung cancer testing positive for ... with 3 complete responses and 33 partial responses. Median ... disease to resume its growth after being slowed by ...
Breaking Biology News(10 mins):Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 2Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 3Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 4Salk scientists receive $3 million for BRAIN Initiative grant 2NEJM: Crizotinib effective in Phase 1 trial against ROS1 lung cancer 2
... pollution is costing each person in Europe around 130 - ... Nitrogen Assessment (ENA) is launched at a conference today in ... from 21 countries and 89 organizations, estimates that the annual ... - 280 billion (70 -320 billion), more than double the ...
... COLUMBUS, Ohio Stress not only sends the human immune ... the trillions of bacteria that work and thrive inside our ... important because those bacteria play a significant role in triggering ... prepared to quickly spring into action in the face of ...
... DETROIT For nearly two decades following the 1991 Gulf War, ... conflict: an unexplainable cluster of symptoms including but not limited ... 2008 that a scientific panel from the U.S. Department of ... served in the Gulf War were suffering from combinations of ...
Cached Biology News:Excessive nitrogen harms the economy and environment -- first Europe-wide assessment published 2Stress wrecks intestinal bacteria, could keep immune system on idle 2WSU receives DOD grant to determine common genetic link among Gulf War Illness patients 2
(Date:10/1/2014)... (PRWEB) October 01, 2014 What: ... software solutions driven by Semantic Web technology, today announced ... in Washington, D.C. , Smart Data solutions provide ... users to rapidly discover, understand, analyze and manage diverse ... Cambridge Semantics, will present on building a “life sciences ...
(Date:10/1/2014)... , Oct. 1, 2014  Spherix Incorporated ... the fostering and monetization of intellectual property, announced ... against VTech and Uniden in the U.S. District ... Texas has been rescheduled for November ... October 2, 2014.  The Court Order setting the ...
(Date:10/1/2014)... CA (PRWEB) September 30, 2014 ... user-friendly, cost-effective tools to address sales, training and ... has developed innovative mobile applications to turn ... outlining the agency’s latest customized mobile app creations, ... http://www.studiopmg.com/work . , In partnership with Toyota, StudioPMG ...
(Date:10/1/2014)... The U.S. Department of Labor has awarded a ... part of the Trade Adjustment Assistance Community College and ... the Department of Labor and Department of Education. , ... Perez and Secretary of Education Arne Duncan announced the ... nearly 270 colleges across the country. , The ...
Breaking Biology Technology:Cambridge Semantics to Present ‘A Useful Approach to Big Data’ at 2014 Big Data Leaders Forum 2Markman Hearing Date for VTech and Uniden Litigation Now Set for November 10, 2014 2Digital Agency Studio PMG Launches New Case Studies on Website 2U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 2U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 3U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 4
... 1, 2011 Elsevier, a world-leading provider ... today announced the availability of Elsevier Urban & ... the life and health sciences, on SciVerse ScienceDirect ... under the renowned German imprint Urban & Fischer, contain ...
... researchers at the University of Toronto have developed the ... This result enables a flexible form factor, not to ... which currently relies on rigid glass. The ... Nature Photonics . OLEDs provide high-contrast and ...
... Moore,s Law, hardly a law but undeniably a persistent trend, ... transistors that fit on a chip roughly doubles. It,s why ... players to movie cameras, from tablets to supercomputers grow ... expensive. Whether the trend can continue until it runs up ...
Cached Biology Technology:Elsevier Announces Availability of Urban & Fischer Journal Archives on SciVerse ScienceDirect 2University of Toronto researchers create world's most efficient flexible OLED on plastic 2A SHARP new microscope for the next generation of biochips 2A SHARP new microscope for the next generation of biochips 3A SHARP new microscope for the next generation of biochips 4
Goat polyclonal to JIK ( Abpromise for all tested applications). Antigen: Synthetic peptide: HKKDHVFIRDEAGHGD, corresponding to amino acids 396-411 of Human JIK. Entrez Gene ID: 51347 Swi...
Mouse monoclonal [SPM325] to Xanthine Oxidase, prediluted ( Abpromise for all tested applications). Antigen: C terminal 358 amino acid fragment of human xanthine oxidase. Entrez Gene ID: 749...
Rab1A...
Drugs and NO-drug Rat Anti-conjugated Acetyl Salicylic Acid Polyclonal Antibody...
Biology Products: