Navigation Links
Erasing the signs of aging in cells is now a reality
Date:11/3/2011

Inserm's AVENIR "Genomic plasticity and aging" team, directed by Jean-Marc Lemaitre, Inserm researcher at the Functional Genomics Institute (Inserm/CNRS/Universit de Montpellier 1 and 2), has recently succeeded in rejuvenating cells from elderly donors (aged over 100). These old cells were reprogrammed in vitro to induced pluripotent stem cells (iPSC) and to rejuvenated and human embryonic stem cells (hESC): cells of all types can again be differentiated after this genuine "rejuvenation" therapy. The results represent significant progress for research into iPSC cells and a further step forwards for regenerative medicine.

The results are published in the Genes & Development Journal dated 1 November 2011.

Human embryonic stem cells (hESC) are undifferentiated multiple-function cells. They can divide and form all types of differentiated adult cells in the body (neurones, cardiac cells, skin cells, liver cells, etc...)

Since 2007, a handful of research teams across the world have been capable of reprogramming human adult cells into induced pluripotent cells (iPSC), which have similar characteristics and potential to human embryonic stem cells (hESC). This kind of reprogramming makes it possible to reform all human cell types without the ethical restrictions related to using embryonic stem cells.

Until now, research results demonstrated that senescence (the final stage of cellular aging) was an obstacle blocking the use of this technique for therapeutic applications in elderly patients.

Today, Inserm researcher Jean-Marc Lemaitre and his team have overcome this obstacle. The researchers have successfully rejuvenated cells from elderly donors, some over 100 years old, thus demonstrating the reversibility of the cellular aging process.

To achieve this, they used an adapted strategy that consisted of reprogramming cells using a specific "cocktail" of six genetic factors, while erasing signs of aging. The research
'/>"/>

Contact: Juliette Hardy
presse@inserm.fr
INSERM (Institut national de la sant et de la recherche mdicale)
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. bioMETRX, Inc. Signs Deal To Acquire Controlling Interest in Biometric Solutions, LLC
2. Unifying the animate and the inanimate designs of nature
3. University of Miami engineer designs stretchable electronics with a twist
4. Engineering technology pinpoints earliest signs of animal life
5. La Jolla Institute signs exclusive license agreement with Medimmune on major asthma discovery
6. UK robot sub searches for signs of melting 60 km into an Antarctic ice shelf cavity
7. Ben-Gurion University of the Negev signs collaborative contract with Bayer CropScience
8. WARF signs license agreement with Pfizer for human embryonic stem cells
9. Web-based program designs more efficient farm terrace layouts
10. University has grand designs to build a house of straw
11. New DNA test uses nanotechnology to find early signs of cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/17/2015)... MedNet Solutions , a global ... management systems, is pleased to announce that company ... in Clinical Trials Southeast conference – March 24-25 ... forum for MedNet to showcase iMedNet , ... eClinical technology platform. We strongly encourage ...
(Date:3/12/2015)... , March 12, 2015 The mascots ... Brenner Children,s Hospital, part of Wake Forest Baptist Medical ... initiative for the 2015 ACC Men,s Basketball Tournament. Young ... with them and getting their autographs. Brenner ... Baptist. It is the only children,s hospital in northwest ...
(Date:3/10/2015)... YORK , March 10, 2015  Continuing its ... the Unexpected, Hammacher Schlemmer introduces The Eye Scanning ... identity before granting access to secure websites or sensitive ... to verify travelers at international borders, the device has ... distinctive pattern points of the iris, converting them into ...
Breaking Biology News(10 mins):Connect With MedNet Solutions At Outsourcing In Clinical Trials Southeast 2Hammacher Schlemmer Introduces The Eye Scanning Password Authenticator 2
... deploy a deflector shield to evade enemy attack, tumor cells ... their own to fend off treatments aimed at killing them. ... their armor. , The cells churn out an enzyme that ... damage from radiation or chemotherapy and promotes tumor cell survival. ...
... of antibodies against the Epstein-Barr virus, the virus that ... develop multiple sclerosis 15 to 20 years later, according ... in the June 2006 print issue of Archives of ... long suspected that external factors may influence the risk ...
... new way of looking beneath the ocean surface that ... , A remote sensor system developed by Associate Professor ... MIT, Northeastern University and the Naval Research Laboratory, allows ... well as small schools, over a 10,000-square-kilometer area - ...
Cached Biology News:Molecular force field helps cancer cells defend against attack 2Molecular force field helps cancer cells defend against attack 3Big hips, big belly? It's in your genes, Joslin-led study shows 2One fish, two fish: New MIT sensor improves fish counts 2
(Date:3/30/2015)... N.J. , March 30, 2015  Naldemedine, ... under development by Shionogi & Co., Ltd., met ... III study (COMPOSE I) for the treatment of ... non-cancer pain receiving opioid therapy. Study results showed ... statistically significantly improved the frequency of spontaneous bowel ...
(Date:3/29/2015)... IRVING, Texas , March 29, 2015 /PRNewswire/ ... two studies in which Caris Molecular Intelligence®, the ... molecular similarities and differences between several rare and ... treatment strategies that have the potential to improve ... Poster Session B at the Society of Gynecologic ...
(Date:3/29/2015)... As a symbol of its commitment ... pharmaceutical manufacturing clients, Whitehouse Laboratories is excited to announce ... Race Team for the 2015 race season. Success on ... a strong sense of precision and attention to detail. ... in the quality control testing laboratory. Sponsorship of the ...
(Date:3/27/2015)... , 27. März 2015  Peter Walter ... Biomedical Science für seine bahnbrechende Arbeit ausgewählt, ... Zellkompartimenten transportiert werden, sowie für die Entschlüsselung ... Reaktion auf Stress nutzen, der mit der ... ist Professor für Biochemie an der University ...
Breaking Biology Technology:Shionogi & Co., Ltd. Announces That Naldemedine Meets Primary Endpoint In A Phase 3 Study For The Treatment Of Opioid-Induced Constipation 2Shionogi & Co., Ltd. Announces That Naldemedine Meets Primary Endpoint In A Phase 3 Study For The Treatment Of Opioid-Induced Constipation 3Caris Molecular Intelligence Facilitates Comparison of Biomarker Profiles to Inform Targeted Treatment Strategies in Distinct Gynecological Cancers 2Caris Molecular Intelligence Facilitates Comparison of Biomarker Profiles to Inform Targeted Treatment Strategies in Distinct Gynecological Cancers 3Caris Molecular Intelligence Facilitates Comparison of Biomarker Profiles to Inform Targeted Treatment Strategies in Distinct Gynecological Cancers 4Whitehouse Laboratories Reaffirms Commitment to Speedy Results – Renews Sponsorship of Berkenstock Racing Team 2Deutschstämmiger Zellbiologe Peter Walter gewinnt den Vilcek Prize in Biomedical Science 2015 2Deutschstämmiger Zellbiologe Peter Walter gewinnt den Vilcek Prize in Biomedical Science 2015 3Deutschstämmiger Zellbiologe Peter Walter gewinnt den Vilcek Prize in Biomedical Science 2015 4
... Conn. Two major steps toward putting quantum computers into ... a qubit onto wires and transmitting the signal to a ... team of scientists at Yale. The accomplishments are reported in ... on which it is highlighted as the cover along with ...
... (Nasdaq: PRXL ), a leading global ... of the acquisition,of Taiwan-based APEX International Clinical ... release. In conjunction with the acquisition and ... its forward-looking,financial guidance for the first quarter ...
... 26 Today at the Clinton Global,Initiative ... a,ground-breaking vaccine to eliminate epidemic meningitis in ... developed by the Meningitis,Vaccine Project, a partnership ... produced by Serum Institute of India Limited ...
Cached Biology Technology:Yale scientists make 2 giant steps in advancement of quantum computing 2Yale scientists make 2 giant steps in advancement of quantum computing 3PAREXEL International Updates Financial Guidance in Conjunction with the Acquisition of APEX International Clinical Research Co., Ltd. and Other Factors 2PAREXEL International Updates Financial Guidance in Conjunction with the Acquisition of APEX International Clinical Research Co., Ltd. and Other Factors 3PAREXEL International Updates Financial Guidance in Conjunction with the Acquisition of APEX International Clinical Research Co., Ltd. and Other Factors 4PATH, World Health Organization, and Partners Introduce Meningitis Vaccine in Burkina Faso 2PATH, World Health Organization, and Partners Introduce Meningitis Vaccine in Burkina Faso 3
... to offer the ATTO-TAG series of ... primary amines. Developed by Novotny and ... reagents are similar to the important ... anthracene-2,3-dicarboxaldehyde, all of which are also ...
Troponin I Immunogen: Full length native protein (purified) (Human). Storage: -20 C, Avoid Freeze/Thaw Cycles...
Corticoliberin...
...
Biology Products: