Navigation Links
Erasing the signs of aging in cells is now a reality
Date:11/3/2011

Inserm's AVENIR "Genomic plasticity and aging" team, directed by Jean-Marc Lemaitre, Inserm researcher at the Functional Genomics Institute (Inserm/CNRS/Universit de Montpellier 1 and 2), has recently succeeded in rejuvenating cells from elderly donors (aged over 100). These old cells were reprogrammed in vitro to induced pluripotent stem cells (iPSC) and to rejuvenated and human embryonic stem cells (hESC): cells of all types can again be differentiated after this genuine "rejuvenation" therapy. The results represent significant progress for research into iPSC cells and a further step forwards for regenerative medicine.

The results are published in the Genes & Development Journal dated 1 November 2011.

Human embryonic stem cells (hESC) are undifferentiated multiple-function cells. They can divide and form all types of differentiated adult cells in the body (neurones, cardiac cells, skin cells, liver cells, etc...)

Since 2007, a handful of research teams across the world have been capable of reprogramming human adult cells into induced pluripotent cells (iPSC), which have similar characteristics and potential to human embryonic stem cells (hESC). This kind of reprogramming makes it possible to reform all human cell types without the ethical restrictions related to using embryonic stem cells.

Until now, research results demonstrated that senescence (the final stage of cellular aging) was an obstacle blocking the use of this technique for therapeutic applications in elderly patients.

Today, Inserm researcher Jean-Marc Lemaitre and his team have overcome this obstacle. The researchers have successfully rejuvenated cells from elderly donors, some over 100 years old, thus demonstrating the reversibility of the cellular aging process.

To achieve this, they used an adapted strategy that consisted of reprogramming cells using a specific "cocktail" of six genetic factors, while erasing signs of aging. The research
'/>"/>

Contact: Juliette Hardy
presse@inserm.fr
INSERM (Institut national de la sant et de la recherche mdicale)
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. bioMETRX, Inc. Signs Deal To Acquire Controlling Interest in Biometric Solutions, LLC
2. Unifying the animate and the inanimate designs of nature
3. University of Miami engineer designs stretchable electronics with a twist
4. Engineering technology pinpoints earliest signs of animal life
5. La Jolla Institute signs exclusive license agreement with Medimmune on major asthma discovery
6. UK robot sub searches for signs of melting 60 km into an Antarctic ice shelf cavity
7. Ben-Gurion University of the Negev signs collaborative contract with Bayer CropScience
8. WARF signs license agreement with Pfizer for human embryonic stem cells
9. Web-based program designs more efficient farm terrace layouts
10. University has grand designs to build a house of straw
11. New DNA test uses nanotechnology to find early signs of cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... have hit on a novel method to help ... and most effective treatment possible., Kidney stones represent ... developing world. If left untreated, apart from being ... and other complications. In many patients treated successfully, ... more effective pathological approach to diagnosis and treatment ...
(Date:4/17/2014)... meeting painted a stark warning on the possible effects ... greenhouse effect 32 times that of carbon dioxide. Now ... substances act as fully regenerable electron acceptors which helps ... wetlands instead of being released to the atmosphere. However, ... it may enter into a vicious cycle to release ...
(Date:4/17/2014)... Indiana University researchers have detected new early-warning signs of ... discovery could have far-reaching implications for the diagnosis and ... over 25 million Americans. , "We had not expected ... such early stages," said Ann Elsner, professor and associate ... author of the study. "We set out to study ...
Breaking Biology News(10 mins):Methane climate change risk suggested by proof of redox cycling of humic substances 2New technique detects microscopic diabetes-related eye damage 2New technique detects microscopic diabetes-related eye damage 3
... who contract gastroenteritis from drinking water contaminated with ... high blood pressure, kidney problems and heart disease in later ... Medical Journal . The findings underline the importance of ... for regular monitoring for those affected. It is estimated ...
... Physical activity promotes changes in the brain that ... of Alzheimer,s disease, according to a new study done ... Carson Smith, an assistant professor of health sciences, included ... gene for Alzheimer,s disease, and other healthy older adults ...
... Va. Since the Civil War, the stethoscope has been ... average doctor may be toting another valuable diagnostic tool: a ... professor of internal medicine at Eastern Virginia Medical School, believes ... years they will become commonplace," he predicts. Dr. Levitov, ...
Cached Biology News:E coli infection linked to long-term health problems 2Study shows importance of exercise for those at special risk for Alzheimer's 2Author predicts widespread acceptance of pocket-sized ultrasound machines 2
(Date:1/15/2014)... 2014 AudioNotch is the internet's leading ... the treatment of tinnitus. Patients listen to sound therapy ... a period of weeks to months, their tinnitus volume decreases. ... forms: Notched Music and Notched White Noise. Now, AudioNotch is ...
(Date:1/14/2014)... 2014 Carahsoft and CDS Federal Services ... 2014 at 2pm EST (11am PST), “Natural Language Processing: ... on how technology can turn raw, heterogeneous data into ... agencies. The online webinar will last approximately one hour. ...
(Date:1/14/2014)... Jan. 14, 2014 As pet owners drew up their lists ... them wrote: "Take better care of my furry companion." Nowadays there ... and top-brand carrying cases to take the little canine or feline ... feel compelled to buy some pricey toys at the pet store. ...
(Date:1/14/2014)... BETHESDA, Md. , Jan. 14, 2014  Organovo ... institutes from the National Institutes of Health (NIH) to ... more effective treatments to patients on a faster timeline. ... Translational Sciences (NCATS) and the National Eye Institute (NEI) ...
Breaking Biology Technology:Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3
... SOUTH SAN FRANCISCO, Calif., Aug. 2, 2011 Rigel Pharmaceuticals, Inc. ... the second quarter and six months ended June 30, 2011. ... a net loss of $21.5 million, or $0.37 per basic ... million, or $0.52 and $0.51 per basic and diluted share, ...
... familiar examples of the five human senses vision, ... in common: when exposed to a sustained change in ... changes without continuing to compare each new change with ... as sensory adaptation, has been recognized by scientists for ...
... that allow us to watch videos, store pictures, and edit ... of "0" and "1" digital data, that is, bits and ... write, store, and retrieve digital information as efficiently as possible. ... by writing information on a thin magnetic layer, where magnetic ...
Cached Biology Technology:Rigel Announces Second Quarter 2011 Financial Results 2Rigel Announces Second Quarter 2011 Financial Results 3Rigel Announces Second Quarter 2011 Financial Results 4Rigel Announces Second Quarter 2011 Financial Results 5Microbial study reveals sophisticated sensory response 2Microbial study reveals sophisticated sensory response 3The art of magnetic writing 2