Navigation Links
Epigenetics could help researchers determine any risks associated with low-dose radiation
Date:2/1/2010

There remains a lack of consensus amongst the medical and scientific communities about any cancer risk from low level radiation, particularly low-dose radiation delivered from computed tomography (CT) scans. However, the study of epigenetics may play a role in determining whether or not future trends of diseases can in fact be linked to utilization of CT, according to an article in the February issue of the Journal of the American College of Radiology (JACR).

The term epigenetics refers to changes in the phenotype (appearance) or gene expression caused by mechanisms other than changes in the underlying DNA sequence. These changes may remain through cell divisions for the remainder of the cell's life and may also last for multiple generations.

"Radiation safety is, without a doubt, a large concern for practicing radiologists today," said Shella Farooki, MD, author of the article and radiologist and director of research for Columbus Radiology Corp in Columbus, OH. "However, the current focus does not account for the possibility of harm to future generations from radiation delivered today. I believe that it is equally, if not more important, to consider potential harm to the patient's offspring and their offspring's offspring," she said.

"The effects of ionizing radiation have been demonstrated in neighboring cells (non-targeted radiation), known as the bystander effect. In addition, ionizing radiation effects have been shown to span generations, resulting in heritable defects in mice. However, we need to bridge the gap between understanding the epigenome functionality and radiation exposure before assuming anything," said Farooki.

"In 2008, the National Institutes of Health (NIH) announced that $190 million had been earmarked for epigenetics research over the next five years," she said. In announcing the funding, government officials noted that epigenetics had the potential to explain mechanisms of aging, human development, and the origins of cancer, heart disease, mental illness, as well as other conditions.

"Epigenetics may ultimately turn out to have a greater role in health and disease and treatment of genetics itself; and given this knowledge, one wonders if future trends in diseases will be linked to today's utilization of CT," said Farooki.

"Clearly, long term epidemiological studies are needed to answer this question, but in the meantime, we are faced with the continued struggle of radiation risk versus benefit," she said.


'/>"/>

Contact: Heather Curry
hcurry@acr-arrs.org
703-390-9822
American College of Radiology / American Roentgen Ray Society
Source:Eurekalert

Related biology news :

1. UD leads $5.3-million research project on rice epigenetics
2. UD leads $5.3-million research project on rice epigenetics
3. Environmental epigenetics has potential for preventing and treating disease
4. The epigenetics of increasing weight through the generations
5. Ali Shilatifard and colleagues aim to clarify the definition of epigenetics
6. New nucleotide could revolutionize epigenetics
7. New piece found in the puzzle of epigenetics
8. Newly created cancer stem cells could aid breast cancer research
9. Obesity and lack of exercise could enhance the risk of pancreatic cancer
10. Finding that 1-in-a-billion that could lead to disease
11. 60 second test could help early diagnosis of common brain diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2016)... June 2, 2016   The Weather Company , an ... Ads, an industry-first capability in which consumers will be able ... to ask questions via voice or text and receive relevant ... Marketers have long sought an advertising solution ... can be personal, relevant and valuable; and can scale across ...
(Date:6/1/2016)... 2016 Favorable Government Initiatives Coupled ... Criminal Identification to Boost Global Biometrics System Market Through ... Research report, " Global Biometrics Market By Type, ... Opportunities, 2011 - 2021", the global biometrics market is ... account of growing security concerns across various end use ...
(Date:5/20/2016)... May 20, 2016  VoiceIt is excited to ... VoicePass. By working together, VoiceIt and ... VoiceIt and VoicePass take slightly different approaches to ... both security and usability. ... this new partnership. "This marketing and ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... Hill, N.C. (PRWEB) , ... June 27, 2016 ... ... U.S. commercial operations for Amgen, will join the faculty of the University ... serve as adjunct professor of strategy and entrepreneurship at UNC Kenan-Flagler, with a ...
(Date:6/27/2016)... , June 27, 2016   Ginkgo Bioworks , ... industrial engineering, was today awarded as one of ... of the world,s most innovative companies. Ginkgo Bioworks ... for the real world in the nutrition, health ... work directly with customers including Fortune 500 companies ...
(Date:6/24/2016)... , June 24, 2016 Epic ... sensitively detects cancers susceptible to PARP inhibitors by ... tumor cells (CTCs). The new test has already ... therapeutics in multiple cancer types. Over ... DNA damage response pathways, including PARP, ATM, ATR, ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Researchers at ... most commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings are the ... read it now. , Diagnostic biomarkers are signposts in the blood, lung fluid ...
Breaking Biology Technology: