Navigation Links
Epigenetic regulation required to ensure correct number of chromosomes
Date:2/16/2014

Abnormal number of chromosomes is often associated with cancer development. In a new study published in the journal Nature Structural and Molecular Biology researchers at Karolinska Institutet in Sweden have shown that a subtle epigenetic change plays an important role in the correct segregation of chromosomes.

Normally when a cell divides, the chromosomes are segregated equally to two daughter cells. However, tumour cells frequently have either too few or too many chromosomes, leading to the incorrect expression of a number of genes. When a cell is about to divide, the cell division machinery takes hold of chromosomes by the centromere so that they may be pulled apart and one copy of each given to the daughter cells.

In the current study, researchers have shown that an epigenetic process, involving the attachment of a small protein to the histone H2B (called H2Bub1), facilitates an important structural change of the centromere immediately prior to cell division. It was previously shown that enzymes that modify histone H2B in this way also play a role in protecting against cancer. This was previously linked to defects in chromosomal repair.

"Our study confirms this role for H2Bub1, but we are extending it to include another mechanism that directly leads to the incorrect number of chromosomes in cells," says Peter Svensson at the Department of Biosciences and Nutrition, one of the researchers who conducted the study.

The researchers behind the new study say that the fact that this mechanism is highly similar in human cells and yeast cells suggests that it plays a key role in ensuring proper chromosome distribution following each cell division. The research has been funded by the Swedish Research Council, and the Swedish Cancer Society.


'/>"/>

Contact: Press Office, Karolinska Institutet
pressinfo@ki.se
46-852-486-077
Karolinska Institutet
Source:Eurekalert

Page: 1

Related biology news :

1. Epigenetic signatures direct the repair potential of reprogrammed cells
2. Epigenetics and epidemiology -- hip, hype and science
3. Not by DNA alone: How the epigenetics revolution is fostering new medicines
4. Scientists discover an epigenetic cause of osteoarthritis
5. Sick from stress? Blame your mom… and epigenetics
6. Epigenetic causes of prostate cancer
7. Scientists uncover mechanism by which plants inherit epigenetic modifications
8. Study finds epigenetics, not genetics, underlies homosexuality
9. More than 3,000 epigenetic switches control daily liver cycles
10. Researchers identify new components of the epigenetic code for honey bee development
11. Epigenetics shapes fate of brain vs. brawn castes in carpenter ants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... -- Research and Markets has announced the addition of ... their offering. The report forecasts ... grow at a CAGR of 12.28% during the period 2016-2020. ... market analysis with inputs from industry experts. The report covers the ... report also includes a discussion of the key vendors operating in ...
(Date:6/22/2016)... June 22, 2016   Acuant , ... verification solutions, has partnered with RightCrowd ® ... for Visitor Management, Self-Service Kiosks and Continuous ... that add functional enhancements to existing physical ... and venues with an automated ID verification ...
(Date:6/21/2016)... 2016 NuData Security announced today that Randy ... principal product architect and that Jon Cunningham ... development. Both will report directly to Christopher ... reflect NuData,s strategic growth in its product and ... demand and customer focus values. ...
Breaking Biology News(10 mins):
(Date:12/7/2016)... ... 07, 2016 , ... A new study published in the ... treated, advanced pancreatic cancer, liquid biopsies are not yet an adequate substitute for ... blood sampling may improve the value of a blood-based test.” The study was ...
(Date:12/7/2016)... Corp. ("Zenith" or the "Company") announces webcast details for a ... and Special Meeting. The Zenith Annual and ... 15, 2016 at Mount Royal University, ... Gate SW, Calgary, Alberta , commencing at ... circular, containing the matters to be considered at the meeting, ...
(Date:12/7/2016)... , Dec. 7, 2016  Vyriad Inc. announced ... to the company,s Board of Directors. "We ... we build our business and develop our oncolytic viruses ... therapy," said Stephen Russell , MD, PhD, CEO ... , share our vision and passion for making a ...
(Date:12/7/2016)... 7, 2016 Regen BioPharma Inc. (OTCQB: ... of Molecular Sciences a team of scientists in ... have demonstrated that expression of NR2F6 in patients with early ... NR2F6 in patient,s cervical cancer tissue as well as in ... "This is an interesting study and the first that I ...
Breaking Biology Technology: