Navigation Links
Epigenetic regulation required to ensure correct number of chromosomes
Date:2/16/2014

Abnormal number of chromosomes is often associated with cancer development. In a new study published in the journal Nature Structural and Molecular Biology researchers at Karolinska Institutet in Sweden have shown that a subtle epigenetic change plays an important role in the correct segregation of chromosomes.

Normally when a cell divides, the chromosomes are segregated equally to two daughter cells. However, tumour cells frequently have either too few or too many chromosomes, leading to the incorrect expression of a number of genes. When a cell is about to divide, the cell division machinery takes hold of chromosomes by the centromere so that they may be pulled apart and one copy of each given to the daughter cells.

In the current study, researchers have shown that an epigenetic process, involving the attachment of a small protein to the histone H2B (called H2Bub1), facilitates an important structural change of the centromere immediately prior to cell division. It was previously shown that enzymes that modify histone H2B in this way also play a role in protecting against cancer. This was previously linked to defects in chromosomal repair.

"Our study confirms this role for H2Bub1, but we are extending it to include another mechanism that directly leads to the incorrect number of chromosomes in cells," says Peter Svensson at the Department of Biosciences and Nutrition, one of the researchers who conducted the study.

The researchers behind the new study say that the fact that this mechanism is highly similar in human cells and yeast cells suggests that it plays a key role in ensuring proper chromosome distribution following each cell division. The research has been funded by the Swedish Research Council, and the Swedish Cancer Society.


'/>"/>

Contact: Press Office, Karolinska Institutet
pressinfo@ki.se
46-852-486-077
Karolinska Institutet
Source:Eurekalert

Page: 1

Related biology news :

1. Epigenetic signatures direct the repair potential of reprogrammed cells
2. Epigenetics and epidemiology -- hip, hype and science
3. Not by DNA alone: How the epigenetics revolution is fostering new medicines
4. Scientists discover an epigenetic cause of osteoarthritis
5. Sick from stress? Blame your mom… and epigenetics
6. Epigenetic causes of prostate cancer
7. Scientists uncover mechanism by which plants inherit epigenetic modifications
8. Study finds epigenetics, not genetics, underlies homosexuality
9. More than 3,000 epigenetic switches control daily liver cycles
10. Researchers identify new components of the epigenetic code for honey bee development
11. Epigenetics shapes fate of brain vs. brawn castes in carpenter ants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... You,ve been here before: you desperately need to sign into ... key or the answer to your secret question. What,s your ... Today, Hoyos Labs , a digital infrastructure security ... an end to the frustration that comes with usernames, passwords ... a user,s smartphone to acquire his or her biometrics to ...
(Date:12/10/2014)... 2014  Wake Forest Baptist Medical Center today announced plans ... of Medicine. Funding for this $50 million capital project ... be publicly launched next summer. The ... 60 series R.J. Reynolds Tobacco Company complex, adjacent to ... immediately with plans to be ready to welcome medical ...
(Date:12/10/2014)... Research and Markets ( http://www.researchandmarkets.com/research/xclcvw/biometrics_market ... "Biometrics Market in Japan 2014-2018" report to ... The integration of biometrics and ... and upgradation of the driver,s license is one ... Besides the aforementioned projects, biometrics is being used ...
Breaking Biology News(10 mins):The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2
... can substantially move California toward its ambitious energy goals, ... allocation of feedstocks and the success of energy efficiency ... "California Energy Future: the Potential for Biofuels," a report ... co-authored by Energy Biosciences Institute scientists Heather Youngs and ...
... University of Southampton have proposed an answer to the long-running ... The Earth, with its core-driven magnetic field, oceans of liquid ... complex system in the known Universe. Life arose on Earth ... would appear that despite planetary scale calamities such as the ...
... microorganism Methanosarcina acetivorans lives off everything it ... of energy, is not yet clear. Scientists at the ... and the USA have identified a protein that might ... in detail and found both similarities and differences to ...
Cached Biology News:Biofuels will play integral role in California's energy future, says new EBI study 2Biofuels will play integral role in California's energy future, says new EBI study 3New study proposes solution to long-running debate as to how stable the Earth system is 2How Archaea might find their food 2
(Date:12/22/2014)... N.C. , Dec. 22, 2014  Alternative ... announced that it has signed a letter of ... that has developed and patented a nanotechnology-based development ... diagnostics products that enable rapid on-site collection and ... use/abuse and health issues in an immediate, non-invasive ...
(Date:12/22/2014)... ITRA Global, one of the largest organizations dedicated ... has further expanded its global reach with the affiliation ... Australia, reports Mylinda Vick, CCIM, Chairman of the ITRA ... ACORPP (Australian Corporate Property and Projects) , is a ... to a wide range of clients in the private ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... Decision Resources Group finds that the Latin ... percent compound annual growth rate through 2023. This is ... the increasing adoption of dental implants. Growing aesthetic consciousness ... spur demand for dental biomaterials because they can improve ... Other key findings from Decision Resources Group,s ...
Breaking Biology Technology:ALNE Announces Intention To Acquire BioTechPharma 2ITRA Global Continues International Expansion in Perth and Brisbane, Australia 2BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 2Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 3
... two new papers, Rice University researchers report using ultracentrifugation ... species. One team, led by Rice Professor Junichiro ... has made a small but significant step toward the ... on highly conductive quantum nanowire. The other, led ...
... , , ... Corp. (TSX:RVX) announced today that it will host a live teleconference and ... Eastern/ 11:00 am Mountain time . The purpose of the teleconference ... slide presentation followed by a question and answer session regarding the impact ...
... GUANGZHOU, China , May 10 /PRNewswire-Asia/ -- China Medicine Corporation,(OTC ... of Western pharmaceuticals, traditional Chinese medicine,products, other nutraceuticals, medical devices, and ... 9:00 a.m. Eastern,Time on Thursday, May 13, 2010 to ... , , ...
Cached Biology Technology:Nano parfait a treat for scientists 2Nano parfait a treat for scientists 3Resverlogix Notice of Conference Call & Webcast for Year End Update 2China Medicine Announces Conference Call to Discuss First Quarter 2010 Results 2
... an imaging based plate reader for ... throughput screening which can utilize both ... light sources and cameras in the ... in photon detection technology. It ...
...
... and supplies, for 10 chips, provides ... perform high-sensitivity RNA analysis (picogram levels) ... automated electrophoresis system. Supplied are 1,250 ... HighSens stain, 20 microliters RNA ladder, ...
... solid. PROTECT FROM LIGHT. PACKAGED UNDER ... that acts as a selective, reversible ... (IC 50 = 4 μM ... and PTP1B 298 , respectively). ...
Biology Products: