Navigation Links
Epigenetic regulation by the MMB/dREAM complex
Date:3/5/2008

In the March 1 issue of G&D, Dr. Joseph Lipsick (Stanford University) and colleagues demonstrate that proteins encoded by the Myb oncogene and the RB tumor suppressor gene function together in the Drosophila MMB/dREAM complex to epigenetically regulate mitotic cell cycle progression.

Drosophila MMB/dREAM includes proteins encoded by the Myb oncogene and the RB and Mip130/Lin-9 tumor suppressor genes, as well as the E2F2 protein which itself binds to the RB protein. While the complex has been previously shown to regulate progression of cell cycle, this paper is the first demonstration of epigenetic regulation of gene expression by Myb and E2F2-RB via the MMB/dREAM complex.

Dr. Lipsick and colleagues found that Myb and E2F2-RB epigenetically regulate expression of the Polo kinase, a key component of cell cycle progression. Using a GFP-Polo reporter gene construct, the researchers were able to monitor Polo gene expression at the level of a single-cell in Drosophila larval imaginal wing discs. They found that flies deficient in both Myb and E2F2 or both Myb and Mip130 displayed variegated patterns of GFP-Polo expression in the same tissue. Furthermore, these patterns of expression were stably inherited through successive rounds of cell division.

Our studies imply that disruptions of the Myb and RB pathways that occur in most human cancers are likely to cause similar epigenetic changes in gene expression. The use of the model organism Drosophila was key to our work because of the powerful experimental tools, the absence of genetic redundancy, and the very well characterized developmental biology in this system.


'/>"/>

Contact: Heather Cosel-Pieper
coselpie@cshl.edu
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1

Related biology news :

1. Environmental epigenetics has potential for preventing and treating disease
2. Einstein researcher receives NIH grant to explore epigenetic regulation of the human genome
3. Human embryonic stem cells remain embryonic because of epigenetic factors
4. UD leads $5.3-million research project on rice epigenetics
5. UD leads $5.3-million research project on rice epigenetics
6. NOAA proposes federal regulations to protect black abalone
7. Stanford researchers publish review of US medical device regulation
8. Physician-scientist urges improved drug regulation to ensure heart safety of non-heart drugs
9. Mechanism for regulation of growth and differentiation of adult muscle stem cells is revealed
10. Regulation of TATA-less promoters
11. The importance of gene regulation for common human disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/4/2017)... 2017  GCE Solutions, a global clinical research organization (CRO), announces ... solution on October 4, 2017. Shadow is designed to assist medical ... policy 0070 of the European Medicines Agency (EMA) in meeting the ... ... ...
(Date:7/20/2017)... 20, 2017 Delta (NYSE: DAL ) customers now ... aircraft at Reagan Washington National Airport (DCA). ... Delta launches biometrics to board aircraft at ... Delta,s biometric boarding pass experience ... is now integrated into the boarding process to allow eligible Delta SkyMiles ...
(Date:6/14/2017)... (NYSE: IBM ) is introducing several innovative partner startups ... collaboration between startups and global businesses, taking place in ... nine startups will showcase the solutions they have built with ... France is one of the ... percent increase in the number of startups created between 2012 ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... ... conjugate (ADC) therapeutics, today confirmed licensing rights that give it exclusive global ... technology developed in collaboration with Children’s Hospital Los Angeles (CHLA). Additionally, ...
(Date:10/10/2017)... SomaGenics announced the receipt of a Phase ... (Single Cell), expected to be the first commercially available ... from single cells using NGS methods. The NIH,s recent ... development of approaches to analyze the heterogeneity of cell ... for measuring levels of mRNAs in individual cells have ...
(Date:10/9/2017)... (PRWEB) , ... October 09, 2017 , ... The award-winning ... to broadcast first quarter 2018. American Farmer airs Tuesdays at 8:30aET on RFD-TV. ... is faced with the challenge of how to continue to feed a growing nation. ...
(Date:10/7/2017)... Arizona (PRWEB) , ... October ... ... 15 years’ experience providing advanced instruments and applications consulting for microscopy and ... in-house expertise in application consulting, Nanoscience Analytical offers a broad range of ...
Breaking Biology Technology: