Navigation Links
Epigenetic regulation by the MMB/dREAM complex
Date:3/5/2008

In the March 1 issue of G&D, Dr. Joseph Lipsick (Stanford University) and colleagues demonstrate that proteins encoded by the Myb oncogene and the RB tumor suppressor gene function together in the Drosophila MMB/dREAM complex to epigenetically regulate mitotic cell cycle progression.

Drosophila MMB/dREAM includes proteins encoded by the Myb oncogene and the RB and Mip130/Lin-9 tumor suppressor genes, as well as the E2F2 protein which itself binds to the RB protein. While the complex has been previously shown to regulate progression of cell cycle, this paper is the first demonstration of epigenetic regulation of gene expression by Myb and E2F2-RB via the MMB/dREAM complex.

Dr. Lipsick and colleagues found that Myb and E2F2-RB epigenetically regulate expression of the Polo kinase, a key component of cell cycle progression. Using a GFP-Polo reporter gene construct, the researchers were able to monitor Polo gene expression at the level of a single-cell in Drosophila larval imaginal wing discs. They found that flies deficient in both Myb and E2F2 or both Myb and Mip130 displayed variegated patterns of GFP-Polo expression in the same tissue. Furthermore, these patterns of expression were stably inherited through successive rounds of cell division.

Our studies imply that disruptions of the Myb and RB pathways that occur in most human cancers are likely to cause similar epigenetic changes in gene expression. The use of the model organism Drosophila was key to our work because of the powerful experimental tools, the absence of genetic redundancy, and the very well characterized developmental biology in this system.


'/>"/>

Contact: Heather Cosel-Pieper
coselpie@cshl.edu
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1

Related biology news :

1. Environmental epigenetics has potential for preventing and treating disease
2. Einstein researcher receives NIH grant to explore epigenetic regulation of the human genome
3. Human embryonic stem cells remain embryonic because of epigenetic factors
4. UD leads $5.3-million research project on rice epigenetics
5. UD leads $5.3-million research project on rice epigenetics
6. NOAA proposes federal regulations to protect black abalone
7. Stanford researchers publish review of US medical device regulation
8. Physician-scientist urges improved drug regulation to ensure heart safety of non-heart drugs
9. Mechanism for regulation of growth and differentiation of adult muscle stem cells is revealed
10. Regulation of TATA-less promoters
11. The importance of gene regulation for common human disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2017)... , May 16, 2017  Veratad Technologies, LLC ( ... online age and identity verification solutions, announced today they ... Conference 2017, May 15 thru May 17, 2017, in ... and International Trade Center. Identity impacts ... and in today,s quickly evolving digital world, defining identity ...
(Date:5/6/2017)... , May 5, 2017 RAM ... announced a new breakthrough in biometric authentication based ... quantum mechanical properties to perform biometric authentication. These new ... semiconductor material created by Ram Group and its ... entertainment, transportation, supply chains and security. Ram Group ...
(Date:4/19/2017)... , April 19, 2017 ... its vendor landscape is marked by the presence of ... is however held by five major players - 3M ... these companies accounted for nearly 61% of the global ... leading companies in the global military biometrics market boast ...
Breaking Biology News(10 mins):
(Date:9/20/2017)... ... September 20, 2017 , ... The ... Agronomic Services (Koch) to feature new innovations aimed at helping farmers solve the ... 2018. American Farmer airs Tuesdays at 8:30aET on RFD-TV. Check your local listings ...
(Date:9/20/2017)... ... September 20, 2017 , ... Diversity focused business accelerator, The Refinery , ... competition to uncover the top technology-driven, women-led startups in Boston, MA, New Haven/Hamden, CT, ... city’s entrepreneurial events going on that week – in Boston, it will be part ...
(Date:9/20/2017)... , ... September 20, 2017 , ... ... and Huron Digital Pathology , a provider of whole slide imaging solutions, ... Visions conference . The workshop, entitled “Successfully Deploying a Best-in-Class Strategy for Digital ...
(Date:9/20/2017)... ... ... From industry leaders, sports stars, and Hollywood icons to thousands of everyday, ... had lost all hope. Their stories are told here. , Chapter 13: ... “Neil takes readers on a riveting journey through the past, present and future of ...
Breaking Biology Technology: