Navigation Links
Epigenetic regulation by the MMB/dREAM complex

In the March 1 issue of G&D, Dr. Joseph Lipsick (Stanford University) and colleagues demonstrate that proteins encoded by the Myb oncogene and the RB tumor suppressor gene function together in the Drosophila MMB/dREAM complex to epigenetically regulate mitotic cell cycle progression.

Drosophila MMB/dREAM includes proteins encoded by the Myb oncogene and the RB and Mip130/Lin-9 tumor suppressor genes, as well as the E2F2 protein which itself binds to the RB protein. While the complex has been previously shown to regulate progression of cell cycle, this paper is the first demonstration of epigenetic regulation of gene expression by Myb and E2F2-RB via the MMB/dREAM complex.

Dr. Lipsick and colleagues found that Myb and E2F2-RB epigenetically regulate expression of the Polo kinase, a key component of cell cycle progression. Using a GFP-Polo reporter gene construct, the researchers were able to monitor Polo gene expression at the level of a single-cell in Drosophila larval imaginal wing discs. They found that flies deficient in both Myb and E2F2 or both Myb and Mip130 displayed variegated patterns of GFP-Polo expression in the same tissue. Furthermore, these patterns of expression were stably inherited through successive rounds of cell division.

Our studies imply that disruptions of the Myb and RB pathways that occur in most human cancers are likely to cause similar epigenetic changes in gene expression. The use of the model organism Drosophila was key to our work because of the powerful experimental tools, the absence of genetic redundancy, and the very well characterized developmental biology in this system.


Contact: Heather Cosel-Pieper
Cold Spring Harbor Laboratory

Page: 1

Related biology news :

1. Environmental epigenetics has potential for preventing and treating disease
2. Einstein researcher receives NIH grant to explore epigenetic regulation of the human genome
3. Human embryonic stem cells remain embryonic because of epigenetic factors
4. UD leads $5.3-million research project on rice epigenetics
5. UD leads $5.3-million research project on rice epigenetics
6. NOAA proposes federal regulations to protect black abalone
7. Stanford researchers publish review of US medical device regulation
8. Physician-scientist urges improved drug regulation to ensure heart safety of non-heart drugs
9. Mechanism for regulation of growth and differentiation of adult muscle stem cells is revealed
10. Regulation of TATA-less promoters
11. The importance of gene regulation for common human disease
Post Your Comments:
(Date:10/29/2015)... 29, 2015  Connected health pioneer, Joseph C. ... of technology-enabled health and wellness, and the business opportunities ... The Internet of Healthy Things . Long ... even existed, Dr. Kvedar, vice president, Connected Health, Partners ... delivery, moving care from the hospital or doctor,s office ...
(Date:10/29/2015)... 2015 Today, LifeBEAM , a ... 2XU, a global leader in technical performance sports ... with advanced bio-sensing technology. The hat will allow ... key biometrics to improve overall training performance. As ... will bring together the most advanced technology, extensive ...
(Date:10/27/2015)... -- Munich, Germany , October ... automatically maps data from mobile eye tracking videos created ... that they can be quantitatively analyzed with SMI,s analysis ... , October 28-29, 2015. SMI,s Automated Semantic Gaze ... tracking videos created with SMI,s Eye Tracking Glasses ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... Nov. 24, 2015  Asia-Pacific (APAC) holds the ... (CRO) market. The trend of outsourcing to low-cost ... but higher volume share for the region in ... however, margins in the CRO industry will improve. ... ( ), finds that the market ...
(Date:11/24/2015)... -- Cepheid (NASDAQ: CPHD ) today announced that ... and invited investors to participate via webcast. ... 1, 2015 at 11.00 a.m. Eastern Time --> ... 1, 2015 at 11.00 a.m. Eastern Time --> ... NY      Tuesday, December 1, 2015 at 11.00 ...
(Date:11/24/2015)... 24, 2015 /CNW/ - iCo Therapeutics ("iCo" or "the ... results for the quarter ended September 30, 2015. ... dollars and presented under International Financial Reporting Standards ... ," said Andrew Rae , President & ... are not only value enriching for this clinical ...
(Date:11/24/2015)... ... 24, 2015 , ... International Society for Pharmaceutical Engineering (ISPE) ... annual events for pharmaceutical manufacturing: 2015 Annual Meeting. The conference took place in ... largest number of attendees in more than a decade. , “The 2015 ...
Breaking Biology Technology: