Navigation Links
'Epigenetic' concepts offer new approach to degenerative disease
Date:4/28/2010

eristic of cancer development.

The good news for cancer and perhaps many other health problems is that "HDAC inhibitors" can stop this degenerative process, and some of them have already been identified in common foods. Examples include sulforaphane in broccoli, indole-3-carbinol in cruciferous vegetables, and organosulfur compounds in vegetables like garlic and onions. Butyrate, a compound produced in the intestine when dietary fiber is fermented, is an HDAC inhibitor, and it provides one possible explanation for why higher intake of dietary fiber might help prevent cancer.

"Metabolism seems to be a key factor, too, generating the active HDAC inhibitor at the site of action," Dashwood said. "In cancer cells, tumor suppressors such as p21 and p53 often become epigenetically silenced. HDAC inhibitors can help turn them on again, and trick the cancer cell into committing suicide via apoptosis.

"We already know some of the things people can do to help prevent cancer with certain dietary or lifestyle approaches," Dashwood said. "Now we're hoping to more fully understand the molecular processes going on, including at the epigenetic level. This should open the door for new approaches to disease prevention or treatment through diet, as well as in complementing conventional drug therapies."

Dashwood, who is also head of LPI's Cancer Chemoprotection Program, will be presenting some of this research in a talk titled "Metabolism as a key to HDAC inhibition by dietary constituents," at the American Society for Biochemistry and Molecular Biology's annual meeting. The talk will take place in Anaheim Convention Center Ballroom E on Wednesday, April 28 at 1:30 pm PST.

OSU scientists recently received an $8.5 million grant from the National Cancer Institute to explore these issues, making the LPI program one of the leaders in the nation on diet, epigenetics, and cancer prevention. The positive findings of laboratory research are alread
'/>"/>

Contact: Nicole Kresge
nkresge@asbmb.org
202-316-5447
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UD leads $5.3-million research project on rice epigenetics
2. UD leads $5.3-million research project on rice epigenetics
3. Human embryonic stem cells remain embryonic because of epigenetic factors
4. Einstein researcher receives NIH grant to explore epigenetic regulation of the human genome
5. Environmental epigenetics has potential for preventing and treating disease
6. Epigenetic regulation by the MMB/dREAM complex
7. Epigenetic changes discovered in major psychosis
8. Scientists clarify a mechanism of epigenetic inheritance
9. Epigenetic research uncovers new targets for modification enzymes
10. The epigenetics of increasing weight through the generations
11. CSHL scientists discover a new way in which epigenetic information is inherited
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... Warwick research finds , Gamblers show the same ... research has shown. , Researchers, led by Dr Elliot ... conducted tests that found that both human gamblers and ... than low-value rewards. , Published in Biology Letters ... the important role that memories of previous biggest wins ...
(Date:8/26/2014)... colony of harmful bacteria, biofilms make the treatment ... a biofilm pose a significant health risk due ... and biofilm-protected bacteria account for some 80 percent ... 50 to 1,000 times more resistant to antibiotics ... may have stumbled onto a magic bullet," said ...
(Date:8/26/2014)... years, increasing pressure from policymakers, consumers, and suppliers ... go beyond reducing the pollutants they emit from ... Today companies must also assess environmental performance at ... of primary materials to the use and recycling ... rise to the discipline known as life cycle ...
Breaking Biology News(10 mins):Gamblers are greedy bird-brains, University of Warwick research finds 2Breakthrough antibacterial approach could resolve serious skin infections 2Breakthrough antibacterial approach could resolve serious skin infections 3Yale journal explores advances in sustainable manufacturing 2
... dams already in question, scientists are reporting that millions ... an important contribution to the greenhouse gases linked to ... than previously believed bubbles out of the water behind ... & Technology . Andreas Maeck and colleagues point ...
... Mice and rats have long since been a standard animal ... of four years on average and high incidence of cancer. ... social tiny African subterranean rodent has a maximum lifespan exceeding ... so far, not a single incident of cancer has been ...
... Inc. released today a white paper detailing BioNimbus, a new ... of a package while it is moving through a 3D ... parts of something a person is viewing, and measure biological ... science of optical, neural and biometric measurement. "We ...
Cached Biology News:The naked mole-rat's secret to staying cancer free 2If you see a puppy on a package, are you more likely to buy it? 2
(Date:8/27/2014)... Palm Beach County, Florida (PRWEB) August 27, 2014 ... & Company Inc. (SCI) is announcing the creation ... board’s priority is to take the SCI’s philosophy ... insuring the company’s research and development actions are ... interpretations. , This new Scientific Advisory Board provides ...
(Date:8/27/2014)... City, OR (PRWEB) August 27, 2014 ... Report, “Consolidation continues to reshape the look and feel ... nutrition. Consumer demand for higher-quality ingredients will push for ... North American market have experienced strong market growth in ... ethical attributes in their food and cosmetics to fit ...
(Date:8/27/2014)... Hunting Valley, Ohio (PRWEB) August 27, 2014 ... five students from Cleveland's University School ... at Case Western Reserve University’s School of ... program provides students with an unparalleled professional experience ... with the School of Medicine faculty and students ...
(Date:8/26/2014)... WA (PRWEB) August 26, 2014 ... for next-generation wearable technology, and inspiration for the ... at this year’s brighter, busier SPIE Optics ... Convention Center. More than 4,400 international scientists, engineers, ... courses, an exhibition, and industry sessions sponsored by ...
Breaking Biology Technology:New Sancilio & Company, Inc. Scientific Board 2New Sancilio & Company, Inc. Scientific Board 3Daring to be Different Raw Materials & Ingredient Supply Shortage Fuels Vital Force™ Technology New Ingredient Enhancements 2Daring to be Different Raw Materials & Ingredient Supply Shortage Fuels Vital Force™ Technology New Ingredient Enhancements 3Students at Cleveland's University School Conduct Biomedical Research at Case Western Reserve University’s School of Medicine 2Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 2Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 3Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 4
... against deadly bacteria. However, how the step from gene to ... To date, B. Pseudomallei, a bacterium suitable for ... in the human body for many years without being detected ... and spread throughout the body, resulting in the patient dying ...
... Apparao Rao and his team are researching nano-scale cantilevers that ... chemicals or gases in the air. Put them into a ... chemical alerts in battle, in industry, in health care and ... devices to do this work has been something we,ve only ...
... 23, 2008 -- Peregrine Pharmaceuticals, Inc. (NASDAQ: PPHM) ... Medicine that supports the broad anti-viral potential ... showing that its PS-targeting drug bavituximab can cure ... , Bavituximab is in clinical trials for ...
Cached Biology Technology:Clemson researchers advance nanoscale electromechanical sensors 2Nature Medicine study shows Peregrine's bavituximab can cure lethal virus infections 2Nature Medicine study shows Peregrine's bavituximab can cure lethal virus infections 3
Human peripheral blood CD19+ B cells, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Monocytes, B Cells, NK Cells and Stem Cells...
Umbilical cord blood CD14+ Monocytes, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood Monocytes, B Cells and NK Cells...
Umbilical cord blood basophils, For immunohistochemistry (IHC)...
Human peripheral blood neutrophils, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Granulocytes...
Biology Products: