Navigation Links
'Epigenetic' concepts offer new approach to degenerative disease
Date:4/28/2010

eristic of cancer development.

The good news for cancer and perhaps many other health problems is that "HDAC inhibitors" can stop this degenerative process, and some of them have already been identified in common foods. Examples include sulforaphane in broccoli, indole-3-carbinol in cruciferous vegetables, and organosulfur compounds in vegetables like garlic and onions. Butyrate, a compound produced in the intestine when dietary fiber is fermented, is an HDAC inhibitor, and it provides one possible explanation for why higher intake of dietary fiber might help prevent cancer.

"Metabolism seems to be a key factor, too, generating the active HDAC inhibitor at the site of action," Dashwood said. "In cancer cells, tumor suppressors such as p21 and p53 often become epigenetically silenced. HDAC inhibitors can help turn them on again, and trick the cancer cell into committing suicide via apoptosis.

"We already know some of the things people can do to help prevent cancer with certain dietary or lifestyle approaches," Dashwood said. "Now we're hoping to more fully understand the molecular processes going on, including at the epigenetic level. This should open the door for new approaches to disease prevention or treatment through diet, as well as in complementing conventional drug therapies."

Dashwood, who is also head of LPI's Cancer Chemoprotection Program, will be presenting some of this research in a talk titled "Metabolism as a key to HDAC inhibition by dietary constituents," at the American Society for Biochemistry and Molecular Biology's annual meeting. The talk will take place in Anaheim Convention Center Ballroom E on Wednesday, April 28 at 1:30 pm PST.

OSU scientists recently received an $8.5 million grant from the National Cancer Institute to explore these issues, making the LPI program one of the leaders in the nation on diet, epigenetics, and cancer prevention. The positive findings of laboratory research are alread
'/>"/>

Contact: Nicole Kresge
nkresge@asbmb.org
202-316-5447
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UD leads $5.3-million research project on rice epigenetics
2. UD leads $5.3-million research project on rice epigenetics
3. Human embryonic stem cells remain embryonic because of epigenetic factors
4. Einstein researcher receives NIH grant to explore epigenetic regulation of the human genome
5. Environmental epigenetics has potential for preventing and treating disease
6. Epigenetic regulation by the MMB/dREAM complex
7. Epigenetic changes discovered in major psychosis
8. Scientists clarify a mechanism of epigenetic inheritance
9. Epigenetic research uncovers new targets for modification enzymes
10. The epigenetics of increasing weight through the generations
11. CSHL scientists discover a new way in which epigenetic information is inherited
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... to assess the pandemic risk from strains of influenza ... not allow ourselves to become complacent that the most ... of scientists. , Influenza pandemics arise when a new ... develop widespread immunity – spreads in the human population. ... 100 years, the worst of which – the 1918 ...
(Date:10/15/2014)... Gutenberg University Mainz (JGU) as a full member, ... maintain a significant nationwide standing in the field ... Johannes Gutenberg University Mainz as a full member ... national and international competition for the best minds ... be proud that Mainz University has been recognized ...
(Date:10/15/2014)... have linked increased resistance to bacterial pneumonia in female ... hormone estrogen. , Females are naturally more resistant to ... scientists has shown that increased resistance to bacterial pneumonia ... oxide synthase 3 (NOS3). They also show that this ... female sex hormone estrogen. , The team, lead by ...
Breaking Biology News(10 mins):Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 3
... seen the story in the news before. Whether it,s the death ... in August, or of an elderly woman gardening in the middle ... condition for which there is no treatment beyond submersion in ice ... to a normal temperature. But, in a new ...
... of what living cells do is carried out by "molecular ... carry out some biological function. How the minute steps of ... a favorite target for creationists. In a study published ... a team of scientists from the University of Chicago and ...
... warmest since global climate has been measured, and while ... plant communities that reflect this warming trend, no study ... until now. With the publication of "Continent-wide ... Advance Online Publication (AOP) in Nature Climate Change ...
Cached Biology News:'Couch potato pill' might stop heat stroke too 2'Couch potato pill' might stop heat stroke too 3Evolution of complexity recreated using 'molecular time travel' 2Evolution of complexity recreated using 'molecular time travel' 3Evolution of complexity recreated using 'molecular time travel' 4European mountain vegetation shows effects of warmer climate 2
(Date:10/22/2014)... BOSTON , Oct. 22, 2014  Actavis ... specialty pharmaceutical company, and Rhythm, a biopharmaceutical company, today ... to acquire Rhythm,s wholly owned subsidiary, Rhythm Health, Inc., ... for the treatment of diabetic gastroparesis and other GI ... successful Phase 2 trial of relamorelin for the treatment ...
(Date:10/22/2014)... WriteResult, LLC – a premier provider ... with a team of researchers from Yale University’s School ... Collaborative to provide electronic questionnaire data collection through use ... started in May, aims to evaluate the impact of ... to and participation in urban agriculture to impact their ...
(Date:10/22/2014)... ROCKVILLE, Md. , Oct. 22, 2014   ... company developing novel pathogen-specific therapies for serious infections and ... Office has issued a Notice of Allowance for a ... product in its C. difficile program, SYN-004. This ... to SYN-004 in the U.S. and adds to the ...
(Date:10/20/2014)... 20, 2014 The report “Pharmacy ... Systems, Packaging and Labeling Systems, Table-top Counters) by ... Global Forecasts & Trends to 2019” analyzes and ... in North America, Europe, Asia-Pacific, and the Rest ... tables and 30 figures spread through 300 pages ...
Breaking Biology Technology:Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 2Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 3Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 4Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 5myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 2myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 3Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 2Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 3Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 4Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 2Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 3Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 4
... CHESTER, Pa., April 1, 2008 VWR International,LLC, ... that it,has acquired Jencons (Scientific) Limited, a UK ... the UK,s largest suppliers of laboratory equipment,and consumables ... company also has,operations in Ireland, Kenya and North ...
... and MONTREAL, April 1 /PRNewswire-FirstCall/ - AEterna,Zentaris ... a global biopharmaceutical company,focused on endocrine therapy ... a leading Canadian specialty pharmaceutical company, announced ... the transactions under their,previously announced purchase and ...
... 1, 2008 Piedmont Heart Institute (PHI),expands its ... practice, Cardiology of Georgia, P.C. (COG), through a ... With eight,locations including Buckhead, Canton, Fayetteville and North ... the Piedmont Heart Institute and an,important addition to ...
Cached Biology Technology:VWR International, LLC Acquires Jencons (Scientific) Ltd, UK 2AEterna Zentaris and Paladin Labs Complete Sale and Purchase of Miltefosine Rights 2AEterna Zentaris and Paladin Labs Complete Sale and Purchase of Miltefosine Rights 3Piedmont Heart Institute Welcomes Cardiology of Georgia 2Piedmont Heart Institute Welcomes Cardiology of Georgia 3Piedmont Heart Institute Welcomes Cardiology of Georgia 4