Navigation Links
Epigenetic changes shed light on biological mechanism of autism
Date:4/23/2013

Scientists from King's College London have identified patterns of epigenetic changes involved in autism spectrum disorder (ASD) by studying genetically identical twins who differ in autism traits. The study, published in Molecular Psychiatry, is the largest of its kind and may shed light on the biological mechanism by which environmental influences regulate the activity of certain genes and in turn contribute to the development of ASD and related behaviour traits.

ASD affects approximately 1 in 100 people in the UK and involves a spectrum of disorders which manifest themselves differently in different people. People with ASD have varying levels of impairment across three common areas: deficits in social interactions and understanding, repetitive behaviour and interests, and impairments in language and communication development.

Evidence from twin studies shows there is a strong genetic component to ASD and previous studies suggest that genes that direct brain development may be involved in the disorder. In approximately 70% of cases, when one identical twin has ASD, so does the other. However, in 30% of cases, identical twins differ for ASD. Because identical twins share the same genetic code, this suggests non-genetic, or epigenetic, factors may be involved.

Epigenetic changes affect the expression or activity of genes without changing the underlying DNA sequence they are believed to be one mechanism by which the environment can interact with the genome. Importantly, epigenetic changes are potentially reversible and may therefore provide targets for the development of new therapies.

The researchers studied an epigenetic mechanism called DNA methylation. DNA methylation acts to block the genetic sequences that drive gene expression, silencing gene activity. They examined DNA methylation at over 27,000 sites across the genome using samples taken from 50 identical twin pairs (100 individuals) from the UK Medical Researc
'/>"/>

Contact: Seil Collins
seil.collins@kcl.ac.uk
44-207-848-5377
King's College London
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Ludwig presents advancements in immunotherapy and epigenetics at the American Association for Cancer Research Annual Meeting
2. Ludwig advancements in immunotherapy and epigenetics top scientific program at AACR
3. Symposium highlights epigenetic effects of milk
4. Epigenetics studies take root in plants
5. Epigenetics mechanism may help explain effects of moms nutrition on her childrens health
6. Life experiences put their stamp on the next generation: New insights from epigenetics
7. Epigenetics shapes fate of brain vs. brawn castes in carpenter ants
8. Researchers identify new components of the epigenetic code for honey bee development
9. More than 3,000 epigenetic switches control daily liver cycles
10. Study finds epigenetics, not genetics, underlies homosexuality
11. Scientists uncover mechanism by which plants inherit epigenetic modifications
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/29/2014)... In popular culture, mathematics is often deemed inaccessible or ... ever more important role in our daily lives and ... new ideas often behind the scenes. , UC ... of Mathematics and an assistant professor of mechanical engineering, ... Some of his recent research published in the ...
(Date:9/29/2014)... Energy Joint Genome Institute (DOE JGI), a DOE ... 32 new projects have been selected for the ... lakes to Caribbean waters, and from plant root ... in forested watersheds, the CSP 2015 projects portfolio ... be extracted. , "These projects catalyze JGI,s ...
(Date:9/29/2014)... What can DNA from the skeleton of a man who ... tell us about ourselves as humans? A great deal when ... oldest in genetic terms found to-date in a region ... years ago. , The man,s maternal DNA, or ,mitochondrial ... prehistory and evolution. Mitochondrial DNA provided the first evidence that ...
Breaking Biology News(10 mins):At the interface of math and science 2At the interface of math and science 3At the interface of math and science 42015 DOE JGI's science portfolio delves deeper into the Earth's data mine 22015 DOE JGI's science portfolio delves deeper into the Earth's data mine 32015 DOE JGI's science portfolio delves deeper into the Earth's data mine 42015 DOE JGI's science portfolio delves deeper into the Earth's data mine 52015 DOE JGI's science portfolio delves deeper into the Earth's data mine 62015 DOE JGI's science portfolio delves deeper into the Earth's data mine 72015 DOE JGI's science portfolio delves deeper into the Earth's data mine 82015 DOE JGI's science portfolio delves deeper into the Earth's data mine 9Ancient human genome from southern Africa throws light on our origins 2Ancient human genome from southern Africa throws light on our origins 3
... finds that the illegal trade in the Roti Island snake-necked turtle, ... but extinct in the wild. Exotic pet enthusiasts in Europe, ... the turtle, often without realizing that they are contributing to its ... since 2001. , The report by TRAFFIC, the wildlife ...
... What makes dancers different than the rest of us? ... University of Jerusalem. , In a study published ... Psychology Prof. Richard P. Ebstein and his research ... consistent differences in two key genes from the general ...
... shown that this part of the brain is essential for ... for over 100 years that if a person suffers a ... suffers difficulties in speaking and with understanding language. However, because ... to test the abilities of such patients on other tasks, ...
Cached Biology News:Illegal trade is propelling rare turtle toward extinction, new report 2Are dancers genetically different than the rest of us? Yes, says Hebrew University researcher 2
(Date:9/30/2014)... September 30, 2014 Back in the 1970’s, ... square feet. per employee, which included space for circulation and ... says Jeff Howell, partner at Nidea Corporate Real Estate ... Toronto. “By the year 2000, however, 250 square feet ... that number come down to 175 to 225 square feet, ...
(Date:9/29/2014)... forefront of diagnostics today, with imaging techniques like ... and NMR (nuclear magnetic resonance) increasing steeply over ... image resolution and quality still limit these techniques ... solution is hyperpolarization, which involves injecting the patient ... following the distribution and fate of specific molecules ...
(Date:9/29/2014)... 2014 Research and Markets  has announced ... Product & Services, End-User , Application - Global Forecast ... The global oligonucleotide synthesis market is expected to ... 2014, growing at a CAGR of 9.8% from 2014 ... on the basis of products and services, applications, end ...
(Date:9/29/2014)... lithium batteries are efficient but involve a range ... alfalfa (lucerne seed) and pine resin and a ... up with a highly interesting alternative. Their study ... ChemSusChem . , ,We think our discovery ... solutions for the batteries of the future, says ...
Breaking Biology Technology:ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 2ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 3A safer approach for diagnostic medical imaging 2A safer approach for diagnostic medical imaging 3Oligonucleotide Synthesis (Diagnostics, PCR, QPCR, Gene Synthesis, NGS, DNA, RNAi) Market - Global Forecast to 2019 2Oligonucleotide Synthesis (Diagnostics, PCR, QPCR, Gene Synthesis, NGS, DNA, RNAi) Market - Global Forecast to 2019 3Smart, eco-friendly new battery to solve problems 2
... Sensitive, Robust, Homogenous,and Rapid Assay , Uses ... a broad range of tyrosine kinases , Requires no ... and in bulk packaging , , Introduction ... accelerated using High Efficiency Fluorescence Polarization (HEFP ) ...
... Kassinos, Irina Osetinsky and Jayne Hesley, Molecular Devices Corporation, 1311 Orleans ... Introduction , ... as tools for monitoring biological events in vivo. They can be ... and yeast, to plants and mammals. The fluorescent proteins are stable, ...
... , Abstract , ... of the FlashPlate as a high throughput screening (HTS) platform for ... coated FlashPlate (SMP103), using two DNA oligos. One of the oligos ... The oligos were preannealed to each other, to form a [ ...
Cached Biology Technology:TKXtra DataFile: Homogenous tyrosine kinase detection using High Efficiency Fluorescence Polarization 2TKXtra DataFile: Homogenous tyrosine kinase detection using High Efficiency Fluorescence Polarization 3measurement of green fluorescent proteins and a red fluorescent protein in live cells in the Analyst GT multimode reader 2measurement of green fluorescent proteins and a red fluorescent protein in live cells in the Analyst GT multimode reader 3measurement of green fluorescent proteins and a red fluorescent protein in live cells in the Analyst GT multimode reader 4measurement of green fluorescent proteins and a red fluorescent protein in live cells in the Analyst GT multimode reader 5Evaluation of FlashPlate in a Helicase Assay 2Evaluation of FlashPlate in a Helicase Assay 3
Shh Antibody Shipping Temperature: HOT Storage Temperature: -20C...
Anti-Cohesin (Scc1/Rad21) Monoclonal Antibody Research Focus: signal transduction Storage: -20C Shipping Temperature: +4C...
... Rabbit monoclonal [EP282Y] to Asparagine ... all tested applications). ... corresponding to residues in the ... Entrez GeneID: ...
Rabbit Anti-melatonin (different linkage) Polyclonal Antibody...
Biology Products: