Navigation Links
Epigenetic changes don't last
Date:9/20/2011

common ancestor. They produced for each individual a complete map of methylated cytosines in the genome, the so-called methylome.

"For each line, we were able to look at about 14 million cytosines," said Claude Becker, a member of the Tbingen team. On average, every plant had almost 3 million methylated cytosines. The vast majority of these were the same in all lines, but about 6 percent had changed since the lines had become separated. At these positions, at least one of the individuals was different, with either methylation gained or lost relative to the ancestor. Each of the lines had about 30,000 such epimutations, which was 1,000 times more than DNA mutations.

With 30,000 epimutations after 30 generations, the geneticists had expected that 1,000 epimutations occurred in each generation. When they directly compared parents and their immediate offspring, they were surprised to find that the epimutation rate was three to four times as high. The scientists concluded that many epimutations are apparently not stable and return to their original state after a few generations. Thus, averaging the mutation rate over many generations is misleading. Becker's colleague Jrg Hagmann therefore cautions not to overestimate the importance of DNA methylation during evolution: "Our experiments show that methylation changes are often reversible". In other words: New epimutations are often not maintained over the long term. "Only when selection wins out over reversion can these epimutations affect evolution," says Hagmann. A new epimutation thus must have a strong evolutionary advantage so that it can become established before being lost again. Because reverse mutations do not necessarily happen in the next generation, it is still possible that epigenetic differences contribute to inheritance of traits between parents and their children or grandparents and their grandchildren.

Another difference to ordinary mutations is that epimutations do not occur ra
'/>"/>

Contact: Detlef Weigel
detlef.weigel@tuebingen.mpg.de
49-707-160-11411
Max-Planck-Gesellschaft
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. CSHL scientists discover a new way in which epigenetic information is inherited
2. CSHL researchers map changing epigenetic modifications that enable transposons to run amok
3. Growth of new brain cells requires epigenetic switch
4. Ali Shilatifard and colleagues aim to clarify the definition of epigenetics
5. New nucleotide could revolutionize epigenetics
6. New piece found in the puzzle of epigenetics
7. Scientists take early steps toward mapping epigenetic variability
8. Epigenetics could help researchers determine any risks associated with low-dose radiation
9. Genomes of identical twins reveal epigenetic changes that may play role in lupus
10. UBC geneticist reveals molecular view of key epigenetic regulator
11. Epigenetic concepts offer new approach to degenerative disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Epigenetic changes don't last
(Date:7/11/2014)... under the normal circumstances, astrocytes participate in ... environment, and exhibit therapeutic and repairing effects ... studies have found that nerve cells differentiated ... have reduced viability, which produces influences on ... Kailuan General Hospital, Hebei United University, China ...
(Date:7/11/2014)... Using spider toxins to study the proteins that let ... say they have stumbled upon a biological tactic that ... insect plagues in a safe and environmentally responsible way. ... be lethal for one species and harmless for a ... target specific pests without harming beneficial species like bees. ...
(Date:7/10/2014)... 2014  The American Academy of Forensic Sciences ... and Technology (NIST) and the Department of Justice ... forensic science expert members to the Forensic Science ... of the NIST,s Organization of Scientific Area Committees ... appointments made to the new FSSB that has ...
Breaking Biology News(10 mins):Potent spider toxin 'electrocutes' German, not American, cockroaches 2Potent spider toxin 'electrocutes' German, not American, cockroaches 3Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 2Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 3
... have tracked a cell-to-cell signaling pathway that designates the ... mice. The scientists succeeded in activating this signal more ... ear. Patches of sensory structures began growing in spots ... contained tufted cells, called hair cells, which respond to ...
... UK researchers, funded by the Biotechnology and Biological Sciences ... coverage of the wheat genome. The release is a ... significant contribution to efforts to support global food security ... The genome sequences released comprise five read-throughs of a ...
... of breeding stallions meaning the horses are less ... that has caused multi-million-dollar losses in the equine industry, ... progress in solving the problem by using an approach ... subfertility without causing stallions the angst of providing testicular ...
Cached Biology News:Tuning into cell signals that tell where sensory organs will form inside the ear 2Tuning into cell signals that tell where sensory organs will form inside the ear 3UK researchers release draft sequence coverage of wheat genome 2UK researchers release draft sequence coverage of wheat genome 3Texas A&M research produces tools to study stallions' subfertility 2
(Date:7/10/2014)... Unraveling life’s mysteries can intrigue, amaze, ... Family purchased a DNA test to unravel ... with a lifetime of memories, sharing, and closeness. In ... DNA genuinely brought the family closer together. , ... genetic history and prior to taking the genetic ...
(Date:7/10/2014)... OMICS Group’s 5th International conference and exhibition ... at Double Tree by Hilton Beijing, China is all ... & Bioanalytical research methods only to facilitate improved living ... Dr. Srinubabu Gedela, MD of OMICS Group Inc has ... one in bringing a unique and international mix of ...
(Date:7/10/2014)... Senior supply chain management executives from over 50 ... of “Reducing Cost, Lead Time, & Defects in the ... the partnership of the Bio Supply Management Alliance ( ... SCMI) of the University of San Diego in ... Institute of Peace and Justice in San Diego, Devendra ...
(Date:7/10/2014)... 2014 On July 9 Prime ... presented Russia,s first national "Industry" ... Company is developing a unique project called MabNext ... a number of innovative drugs based on monoclonal antibodies ... took place at the International Exhibition "Innoprom 2014" in ...
Breaking Biology Technology:Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2
... Feb. 5 Memory Pharmaceuticals,Corp. (Nasdaq: MEMY ... Chief,Executive Officer, will provide a company update at ... Tuesday, February 12, 2008 at 10:15 a.m. ET ... Interested parties may access the live webcast of ...
... 5 ViroPharma Incorporated,(Nasdaq: VPHM ) today ... operating officer of ViroPharma, will present at the ... on Monday, February 11, 2008. The,conference is being ... ViroPharma,s presentation will be webcast live for investors ...
... Feb. 5 Physicians Reference,Laboratory ("PRL") announced today that ... to date. Under the marketed,name COMPLeTe Care HPV, the ... high risk types of HPV which can lead to,cervical ... common form of female,cancer with an incidence of over ...
Cached Biology Technology:Physicians Reference Laboratory Announces New Diagnostic for Women's Health 2
Normal human serum, single donor...
... Beacon Designer designs oligos for SYBR ... beacon, NASBA and FRET assays. Highly specific ... found by automatically interpreting BLAST search results. ... secondary structures identified by connecting to the ...
Agar, 5 lb. Bacteriological.Moisture: < 10%, ash: < 6.5%. Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
Request Info...
Biology Products: