Navigation Links
Epigenetic causes of prostate cancer
Date:9/5/2012

This press release is available in German.

In about half of all prostate tumours, there are two genetic areas that are fused with one another. When this is not the case, the exact way cancer cells originate in prostate tumours was not clear until now. Scientists at the Max Planck Institute for Molecular Genetics in Berlin, in cooperation with a team of international researchers, were able to show that the genesis of this fusion-negative prostate cancer has epigenetic causes: methyl groups are distributed differently over the DNA in the cancer cells than in healthy cells. Thanks to this knowledge, physicians may be able to achieve greater specificity in treating prostate tumours in future. In addition, the aberrant DNA methylations can be used as a potential biomarker for identifying prostate cancer.

About half of all cases of prostate cancer originate through fusion of two genetic areas. As a result, the ERG gene is activated in these fusion-positive cells and prostate cells propagate, leading to tumourigenesis. Fusion-positive prostate cancer can be treated with PARP1 inhibitors that turn off the repair system of the tumour cells.

However, it has not been clear how prostate tumours without a fused ERG gene acquire their tumourigenic potential. Now, a team of Max Planck scientists headed by Michal-Ruth Schweiger from the Department of Vertebrate Genomics have investigated the global DNA methylation pattern i.e. at which locations the DNA possesses methyl groups in fusion-negative tumours. They have discovered that, compared to fusion-positive tumours, the fusion-negative tumours display more aberrant DNA methylations, which are most likely causative for the malignant transformation of prostate cells.

Moreover, the scientists found large amounts of the enzyme EZH2 in the cells of the tumours. This histone methyltransferase couples
'/>"/>

Contact: Dr. Michal-Ruth Schweiger
mschweig@molgen.mpg.de
49-308-413-1339
Max-Planck-Gesellschaft
Source:Eurekalert

Page: 1 2

Related biology news :

1. Sick from stress? Blame your mom… and epigenetics
2. Scientists discover an epigenetic cause of osteoarthritis
3. Not by DNA alone: How the epigenetics revolution is fostering new medicines
4. Epigenetics and epidemiology -- hip, hype and science
5. Epigenetic signatures direct the repair potential of reprogrammed cells
6. Too much protein HUWE1 causes intellectual disability
7. Vitamin B12 deficiency: Tracing the causes
8. Vitamin B12 deficiency: Tracking the genetic causes
9. Warming causes more extreme shifts of the Southern Hemispheres largest rain band
10. Massachusetts Eye and Ear researchers discover elusive gene that causes a form of blindness from birth
11. Study points to causes of high dolphin deaths in Gulf of Mexico
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/16/2014)... challenged conventional thinking on how the bowel lining develops ... how bowel cancer starts. , The researchers produced evidence ... the ,crypts, that are a feature of the bowel ... bowel cancer development, a controversial finding as scientists are ... 3D imaging technologies, Dr Chin Wee Tan and Professor ...
(Date:10/16/2014)... severe respiratory tract infections and worldwide claims the ... VIB and Ghent University have succeeded in developing ... virus infection. , Xavier Saelens (VIB/UGent): "We ... way for the development of a novel approach ... suffering in numerous small children and elderly people." ...
(Date:10/16/2014)... 16, 2014 NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile commerce ... including Wocket™, the Smart Wallet, at the 13 th ... a leading global conference on the intersection of technology ... Mark Anderson , founder and publisher of the Strategic ...
Breaking Biology News(10 mins):Cryptic clues drive new theory of bowel cancer development 2New perspectives for development of an RSV vaccine 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 3
... blood and marrow transplant physician Naynesh Kamani, ... a new national clinical trial of unrelated donor marrow ... sickle cell disease . Children,s National will join more ... II clinical trial of this treatment. If successful, the ...
... the "air pollution danger zone," according to new research ... researchers have found that more than 30 percent of ... quarter mile, of major highways that consistently serve as ... shown that proximity to major highwaysand thus environmental pollutants, ...
... bees industriously bring pollen and nectar to the hive, ... of pesticides, according to Penn State researchers. Add the ... structure of the hive, and bee researchers see a ... approach may mitigate at least some beeswax contamination. ...
Cached Biology News:Children's national co-leads nationwide study of landmark sickle cell treatment 2Many US public schools in 'air pollution danger zone' 2Many US public schools in 'air pollution danger zone' 3Pesticide build-up could lead to poor honey bee health 2Pesticide build-up could lead to poor honey bee health 3Pesticide build-up could lead to poor honey bee health 4
(Date:10/18/2014)... Asia-Pacific Liquid Crystal on Silicon (LCoS) display market report ... analysis and forecast of revenue. This market was valued ... reach $380.0 million by 2018, at a CAGR of ... TOC of the Asia-Pacific LCoS display market report, to ... also provides a glimpse of the segmentation of the ...
(Date:10/18/2014)... October 18, 2014 According to a ... & Well Type - Global Trends & Forecasts up ... $31 billion in 2011. This value is expected to ... by 2017, with 10% CAGR during the same period. ... fracturing production market in terms of hydraulic horse power ...
(Date:10/17/2014)... Air Force Office of Scientific Research grant to examine ... that will provide clues for predicting fatigue in aircraft ... said the new technology and process would be better ... wing., "We,ll be able to determine metal fatigue at ... this scale," Huang said. "Certain patterns of surface roughness ...
(Date:10/17/2014)... 17, 2014 For the seventh ... as published in today’s print issue of Science ... Top Employers Survey polled employees in the biotechnology, ... best employers. Rankings were determined based on ... rate their companies on 23 characteristics, including financial ...
Breaking Biology Technology:The Asia-Pacific Liquid Crystal on Silicon (LCoS) display market is expected to reach $380.0 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Liquid Crystal on Silicon (LCoS) display market is expected to reach $380.0 million by 2018 - New Report by MicroMarket Monitor 3Hydraulic Fracturing Market Projected To Reach $64 Billion by 2017 - New Report by MarketsandMarkets 2Hydraulic Fracturing Market Projected To Reach $64 Billion by 2017 - New Report by MarketsandMarkets 3Hydraulic Fracturing Market Projected To Reach $64 Billion by 2017 - New Report by MarketsandMarkets 4UT Arlington project to detect possible damages in aircraft parts early in process 2DuPont Named Top Employer by Science Magazine 2DuPont Named Top Employer by Science Magazine 3
... Jan. 14 /PRNewswire-FirstCall/ - Medical International Technology Inc. (MDLH.OB) ... it has received clearance by FINRA to be traded on the ... for trading on the OTC Bulletin Board at the opening of ... , This is very positive news for all existing and future ...
... ... Education and Local Youth by establishing Five College Scholarships. The first is a ... studies at NoVA. The company will also sponsor four scholarships for community-active, graduating ... ...
... , WILMINGTON, Del. , and FLORHAM PARK, N.J. , ... BASF Plant Science announced they have reached an agreement on a patent ... suit against each other in U.S. Federal Court in the District of ... biotechnology traits, including traits that provide tolerance to ALS herbicides. , DuPont ...
Cached Biology Technology:MIT is pleased to announce that it has received clearance by FINRA to be listed on the OTC Bulletin Board "MDLH.OB" 2RiVIdium Inc. Creates Five Local Scholarships 2DuPont and BASF Announce Settlement 2DuPont and BASF Announce Settlement 3
Human TFPI Affinity Purified Polyclonal Ab Protein Family: Coagulation, Inflammation, Serine Protease Regulators...
TMB Slow Kinetic One Component HRP Microwell Substrate, 1 L...
Eppendorf tube holder, for Tube rack 175 x 12 mm, 100. Category: Chromatography Systems & Accessories, Systems....
Pooled normal sreum with 0.1% sodium azide as preservative...
Biology Products: