Navigation Links
Epigenetic causes of prostate cancer
Date:9/5/2012

This press release is available in German.

In about half of all prostate tumours, there are two genetic areas that are fused with one another. When this is not the case, the exact way cancer cells originate in prostate tumours was not clear until now. Scientists at the Max Planck Institute for Molecular Genetics in Berlin, in cooperation with a team of international researchers, were able to show that the genesis of this fusion-negative prostate cancer has epigenetic causes: methyl groups are distributed differently over the DNA in the cancer cells than in healthy cells. Thanks to this knowledge, physicians may be able to achieve greater specificity in treating prostate tumours in future. In addition, the aberrant DNA methylations can be used as a potential biomarker for identifying prostate cancer.

About half of all cases of prostate cancer originate through fusion of two genetic areas. As a result, the ERG gene is activated in these fusion-positive cells and prostate cells propagate, leading to tumourigenesis. Fusion-positive prostate cancer can be treated with PARP1 inhibitors that turn off the repair system of the tumour cells.

However, it has not been clear how prostate tumours without a fused ERG gene acquire their tumourigenic potential. Now, a team of Max Planck scientists headed by Michal-Ruth Schweiger from the Department of Vertebrate Genomics have investigated the global DNA methylation pattern i.e. at which locations the DNA possesses methyl groups in fusion-negative tumours. They have discovered that, compared to fusion-positive tumours, the fusion-negative tumours display more aberrant DNA methylations, which are most likely causative for the malignant transformation of prostate cells.

Moreover, the scientists found large amounts of the enzyme EZH2 in the cells of the tumours. This histone methyltransferase couples
'/>"/>

Contact: Dr. Michal-Ruth Schweiger
mschweig@molgen.mpg.de
49-308-413-1339
Max-Planck-Gesellschaft
Source:Eurekalert

Page: 1 2

Related biology news :

1. Sick from stress? Blame your mom… and epigenetics
2. Scientists discover an epigenetic cause of osteoarthritis
3. Not by DNA alone: How the epigenetics revolution is fostering new medicines
4. Epigenetics and epidemiology -- hip, hype and science
5. Epigenetic signatures direct the repair potential of reprogrammed cells
6. Too much protein HUWE1 causes intellectual disability
7. Vitamin B12 deficiency: Tracing the causes
8. Vitamin B12 deficiency: Tracking the genetic causes
9. Warming causes more extreme shifts of the Southern Hemispheres largest rain band
10. Massachusetts Eye and Ear researchers discover elusive gene that causes a form of blindness from birth
11. Study points to causes of high dolphin deaths in Gulf of Mexico
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... the Wildlife Conservation Society shows that no-take zones ... species such as lobster, conch, and fish recover ... reef areas. , The reporttitled "Review of the ... research literature from no-take areas around the world. ... a recognized expert in marine protected areas and ...
(Date:7/11/2014)... Tenn., July 11, 2014--Researchers at the Department of ... R&D 100 awards, presented by R&D Magazine in ... , "These awards recognize the tremendous value of ... Moniz. "Research and development at the National Labs ... challenges and pursue the scientific and technological innovations ...
(Date:7/11/2014)... New South Wales, Australia when NASA,s Aqua satellite passed ... July 11 (12:35 p.m. local time/11:35 p.m. EDT on ... Wales (NSW), the Moderate Resolution Imaging Spectroradiometer (MODIS) aboard ... spotted smoke (light brown) from various fires. Actively burning ... red. , The New South Wales, Australia Government website ...
Breaking Biology News(10 mins):Belize's lobster, conch, and fish populations rebuild in no-take zones 2ORNL wins eight R&D 100s 2ORNL wins eight R&D 100s 3ORNL wins eight R&D 100s 4
... than 99 percent of all modern potato varieties planted ... grew in the lowlands of south-central Chile. How Chilean ... from Europe-has been the subject of a long, contentious ... have maintained that Chilean potatoes were the first to ...
... Management and Budget evaluates R&D programs at the U.S. ... that asks about many aspects of their research, including ... answers, and an "ineffective" rating can have serious adverse ... trouble meeting OMB,s requirements to measure and demonstrate efficiency, ...
... ON. January 29, 2007 A new study sheds ... pregnantor are exposed to second-hand smokeand an increased risk ... University have found a mechanism that explains why an ... a hypoxic episodeis dramatically compromised by exposure to nicotine ...
Cached Biology News:Using DNA, scientists hunt for the roots of the modern potato 2New research explains link between smoking and SIDS 2
(Date:7/13/2014)... 2014 2014 Deep Research Report on ... and in-depth study on the current state of the ... report provides a basic overview of the industry, including ... and Chinese domestic market analysis are provided with a ... the market. A comparison between the international and Chinese ...
(Date:7/12/2014)... York (PRWEB) July 12, 2014 ... for various reagents used in the life ... driving the life science reagents market towards ... include manufacturers and providers of life science ... Market Report: http://www.transparencymarketresearch.com/life-sciences-reagents-analytical-reagents.html . , The ...
(Date:7/11/2014)... PALM BEACH, Fla. , July 11, 2014 /PRNewswire-iReach/ ... variety of high-quality peptides that are used solely in ... To honor two successful years in business, Maxim Peptide, ... LLC, has just launched a new and updated website ... the research blog section has been updated with fascinating ...
(Date:7/11/2014)... , July 11, 2014 , ... part) in, into or from any jurisdiction where to do ... such jurisdiction.  Shire plc ("Shire" or the "Company") ... article this afternoon.  Shire confirms it has held a meeting ... made by Shire without the prior agreement or approval of ...
Breaking Biology Technology:2014 Nano Silver Industry in Global and China Regions Development Proposals Analysis Available at DeepResearchReports.com 22014 Nano Silver Industry in Global and China Regions Development Proposals Analysis Available at DeepResearchReports.com 3Transparency Market Research: Life Science Reagents Market- PCR Reagent Kits, Cell and Tissue Culture, Flow Cytometry, Electrophoresis and Chromatography 2Transparency Market Research: Life Science Reagents Market- PCR Reagent Kits, Cell and Tissue Culture, Flow Cytometry, Electrophoresis and Chromatography 3Maxim Peptide Celebrates Second Anniversary Online with an Updated Website and Special Deals Section 2Shire plc - Statement re: Media Speculation 2
... that TechStar will receive a two-year grant from the ... research institutions in Milwaukee, which for years trailed their ... are aspiring to catch up. Thats good news for ... economy. , ,If Milwaukee wants to transform itself from ...
... in the field and navigating at the helm of several ... (which is located in Woodridge, Ill. across from Argonne ... advance his drug discovery company. , ,Following a six-month ... the next few weeks with financial adviser Legg Mason ...
... WI - Automating Peripherals Inc announced that the ... security standards mandated by the Health Insurance Portability ... Commission on Accreditation of Healthcare Organizations (JCAHO). SecurALL ... organizations regulate and monitor facility access throughout an ...
Cached Biology Technology:Milwaukee research institutions step up the pace for technology transfer 2Advanced Life Sciences to Hit the Road For $30 Million in Funding 2Advanced Life Sciences to Hit the Road For $30 Million in Funding 3Advanced Life Sciences to Hit the Road For $30 Million in Funding 4
...
... PlusOne Silver Staining Kit, Protein, 1. ... and Dernick (1), the kit gives ... electrophoresis systems.Silver Staining Kit, Protein provides ... proteins in polyacrylamide gels in less ...
Mouse monoclonal [IFR0104] to Salmonella enteriditis ( Abpromise for all tested applications)....
Cyno macaque plasma and serum - various quantities available...
Biology Products: