Navigation Links
Epigenetic causes of prostate cancer
Date:9/5/2012

This press release is available in German.

In about half of all prostate tumours, there are two genetic areas that are fused with one another. When this is not the case, the exact way cancer cells originate in prostate tumours was not clear until now. Scientists at the Max Planck Institute for Molecular Genetics in Berlin, in cooperation with a team of international researchers, were able to show that the genesis of this fusion-negative prostate cancer has epigenetic causes: methyl groups are distributed differently over the DNA in the cancer cells than in healthy cells. Thanks to this knowledge, physicians may be able to achieve greater specificity in treating prostate tumours in future. In addition, the aberrant DNA methylations can be used as a potential biomarker for identifying prostate cancer.

About half of all cases of prostate cancer originate through fusion of two genetic areas. As a result, the ERG gene is activated in these fusion-positive cells and prostate cells propagate, leading to tumourigenesis. Fusion-positive prostate cancer can be treated with PARP1 inhibitors that turn off the repair system of the tumour cells.

However, it has not been clear how prostate tumours without a fused ERG gene acquire their tumourigenic potential. Now, a team of Max Planck scientists headed by Michal-Ruth Schweiger from the Department of Vertebrate Genomics have investigated the global DNA methylation pattern i.e. at which locations the DNA possesses methyl groups in fusion-negative tumours. They have discovered that, compared to fusion-positive tumours, the fusion-negative tumours display more aberrant DNA methylations, which are most likely causative for the malignant transformation of prostate cells.

Moreover, the scientists found large amounts of the enzyme EZH2 in the cells of the tumours. This histone methyltransferase couples histone and DNA methylation and also transfers methyl groups to the DNA. Further functional analyses link EZH2 to the aberrant DNA methylations in fusion gene negative tumours. As reason for the significantly increased amount of EZH2 the scientists found very low concentrations of miRNA-26a, a micro-RNA that targets EZH2 for degradation.


'/>"/>
Contact: Dr. Michal-Ruth Schweiger
mschweig@molgen.mpg.de
49-308-413-1339
Max-Planck-Gesellschaft
Source:Eurekalert

Related biology news :

1. Sick from stress? Blame your mom… and epigenetics
2. Scientists discover an epigenetic cause of osteoarthritis
3. Not by DNA alone: How the epigenetics revolution is fostering new medicines
4. Epigenetics and epidemiology -- hip, hype and science
5. Epigenetic signatures direct the repair potential of reprogrammed cells
6. Too much protein HUWE1 causes intellectual disability
7. Vitamin B12 deficiency: Tracing the causes
8. Vitamin B12 deficiency: Tracking the genetic causes
9. Warming causes more extreme shifts of the Southern Hemispheres largest rain band
10. Massachusetts Eye and Ear researchers discover elusive gene that causes a form of blindness from birth
11. Study points to causes of high dolphin deaths in Gulf of Mexico
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2016)... , March 31, 2016   ... ("LegacyXChange" or the "Company") LegacyXChange is excited ... of its soon to be launched online site for ... https://www.youtube.com/channel/UCyTLBzmZogV1y2D6bDkBX5g ) will also provide potential shareholders a ... DNA technology to an industry that is notorious for ...
(Date:3/23/2016)... Massachusetts , March 23, 2016 /PRNewswire/ ... im Interesse erhöhter Sicherheit Gesichts- und Stimmerkennung ... Xura, Inc. (NASDAQ: MESG ), ... bekannt, dass das Unternehmen mit SpeechPro zusammenarbeitet, ... aus der Finanzdienstleistungsbranche, wird die Möglichkeit angeboten, ...
(Date:3/21/2016)... Massachusetts , March 22, 2016 ... facial recognition with passcodes for superior security   ... ), a leading provider of secure digital communications services, ... their biometric technology and offer enterprise customers, particularly those ... secure facial recognition and voice authentication within a mobile ...
Breaking Biology News(10 mins):
(Date:4/28/2016)... India , April 28, 2016 ... JT, Stirling, and Brayton Cryocoolers), Service (Technical Support, Product ... and Geography - Global Forecast to 2022", published by ... USD 2.94 Billion by 2022, at a CAGR of ... 70 market data Tables and 94 Figures spread through ...
(Date:4/28/2016)... (PRWEB) , ... April 28, 2016 , ... ... and ongoing support for Connecticut's innovative, growing companies, today announced the launch of ... and financial technology (fintech) companies. , “VentureClash looks to attract the ...
(Date:4/28/2016)... ... April 28, 2016 , ... As part of ... industry experts, and expanding its LATAM network and logistics capabilities. Enhancements have ... manage their clinical trial projects. , The expansion will provide unmatched clinical trial ...
(Date:4/27/2016)... ... April 27, 2016 , ... Cambridge Semantics, ... web technology, today announced that it has been named to The Silicon Review’s “20 ... services and other markets, Cambridge Semantics serves the needs of end users facing some ...
Breaking Biology Technology: