Navigation Links
Epigenetic causes of prostate cancer
Date:9/5/2012

This press release is available in German.

In about half of all prostate tumours, there are two genetic areas that are fused with one another. When this is not the case, the exact way cancer cells originate in prostate tumours was not clear until now. Scientists at the Max Planck Institute for Molecular Genetics in Berlin, in cooperation with a team of international researchers, were able to show that the genesis of this fusion-negative prostate cancer has epigenetic causes: methyl groups are distributed differently over the DNA in the cancer cells than in healthy cells. Thanks to this knowledge, physicians may be able to achieve greater specificity in treating prostate tumours in future. In addition, the aberrant DNA methylations can be used as a potential biomarker for identifying prostate cancer.

About half of all cases of prostate cancer originate through fusion of two genetic areas. As a result, the ERG gene is activated in these fusion-positive cells and prostate cells propagate, leading to tumourigenesis. Fusion-positive prostate cancer can be treated with PARP1 inhibitors that turn off the repair system of the tumour cells.

However, it has not been clear how prostate tumours without a fused ERG gene acquire their tumourigenic potential. Now, a team of Max Planck scientists headed by Michal-Ruth Schweiger from the Department of Vertebrate Genomics have investigated the global DNA methylation pattern i.e. at which locations the DNA possesses methyl groups in fusion-negative tumours. They have discovered that, compared to fusion-positive tumours, the fusion-negative tumours display more aberrant DNA methylations, which are most likely causative for the malignant transformation of prostate cells.

Moreover, the scientists found large amounts of the enzyme EZH2 in the cells of the tumours. This histone methyltransferase couples histone and DNA methylation and also transfers methyl groups to the DNA. Further functional analyses link EZH2 to the aberrant DNA methylations in fusion gene negative tumours. As reason for the significantly increased amount of EZH2 the scientists found very low concentrations of miRNA-26a, a micro-RNA that targets EZH2 for degradation.


'/>"/>
Contact: Dr. Michal-Ruth Schweiger
mschweig@molgen.mpg.de
49-308-413-1339
Max-Planck-Gesellschaft
Source:Eurekalert

Related biology news :

1. Sick from stress? Blame your mom… and epigenetics
2. Scientists discover an epigenetic cause of osteoarthritis
3. Not by DNA alone: How the epigenetics revolution is fostering new medicines
4. Epigenetics and epidemiology -- hip, hype and science
5. Epigenetic signatures direct the repair potential of reprogrammed cells
6. Too much protein HUWE1 causes intellectual disability
7. Vitamin B12 deficiency: Tracing the causes
8. Vitamin B12 deficiency: Tracking the genetic causes
9. Warming causes more extreme shifts of the Southern Hemispheres largest rain band
10. Massachusetts Eye and Ear researchers discover elusive gene that causes a form of blindness from birth
11. Study points to causes of high dolphin deaths in Gulf of Mexico
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2016)... Israel , April 14, 2016 ... Authentication and Malware Detection, today announced the appointment of ... assumed the new role. Goldwerger,s leadership appointment ... on the heels of the deployment of its platform ... BioCatch,s behavioral biometric technology, which discerns unique cognitive and ...
(Date:3/29/2016)... March 29, 2016 LegacyXChange, Inc. ... "LEGX" and SelectaDNA/CSI Protect are pleased to announce our ... in a variety of writing instruments, ensuring athletes signatures ... created collectibles from athletes on LegacyXChange will be assured ... the DNA. Bill Bollander , CEO ...
(Date:3/21/2016)... Massachusetts , March 22, 2016 ... facial recognition with passcodes for superior security   ... ), a leading provider of secure digital communications services, ... their biometric technology and offer enterprise customers, particularly those ... secure facial recognition and voice authentication within a mobile ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016  The Prostate Cancer Foundation (PCF) ... precise treatments and faster cures for prostate cancer. Members of the Class of ... 15 countries. Read More About the Class of 2016 ... ... ...
(Date:6/23/2016)... ... June 23, 2016 , ... STACS DNA Inc., the sample tracking software ... State Crime Laboratory, has joined STACS DNA as a Field Application Specialist. , ... Tremblay, President and COO of STACS DNA. “In further expanding our capacity as a ...
(Date:6/23/2016)... LONDON , June 23, 2016 ... & Hematology Review, 2016;12(1):22-8 http://doi.org/10.17925/OHR.2016.12.01.22 ... Review , the peer-reviewed journal from touchONCOLOGY, ... the escalating cost of cancer care is placing ... a result of expensive biologic therapies. With the ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... a new line of intelligent tools designed, tuned and optimized exclusively for Okuma ... 12–17 in Chicago. The result of a collaboration among several companies with expertise ...
Breaking Biology Technology: